Unlisted - International Colle (1988)
Graduate School
Northwestern University (1991)
Graduate School
University of Calgary - Canada (1996)

Research Interest

  • Alzheimer disease
  • Cell and Molecular Biology
  • Gamma-secretase
  • Neurodegeneration
  • Neuroscience


Featured Publications LegendFeatured Publications

Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior.
Dries DR, Zhu Y, Brooks MM, Forero DA, Adachi M, Cenik B, West JM, Han YH, Yu C, Arbella J, Nordin A, Adolfsson R, Del-Favero J, Lu QR, Callaerts P, Birnbaum SG, Yu G J. Biol. Chem. 2016 Mar
The function of RNA-binding proteins at the synapse: implications for neurodegeneration.
Sephton CF, Yu G Cell. Mol. Life Sci. 2015 Jun
Activity-dependent FUS dysregulation disrupts synaptic homeostasis.
Sephton CF, Tang AA, Kulkarni A, West J, Brooks M, Stubblefield JJ, Liu Y, Zhang MQ, Green CB, Huber KM, Huang EJ, Herz J, Yu G Proc. Natl. Acad. Sci. U.S.A. 2014 Oct
Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV, Green A, Gan L J. Exp. Med. 2014 Aug
Rescue of peripheral and CNS axon defects in mice lacking NMNAT2.
Gilley J, Adalbert R, Yu G, Coleman MP J. Neurosci. 2013 Aug 33 33 13410-24
Secreted progranulin is a homodimer and is not a component of high-density lipoproteins (HDL).
Nguyen AD, Nguyen TA, Cenik B, Yu G, Herz J, Walther TC, Davidson WS, Farese RV J. Biol. Chem. 2013 Jan
Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.
Cenik B, Sephton CF, Kutluk Cenik B, Herz J, Yu G J. Biol. Chem. 2012 Sep 287 39 32298-306
TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration.
Sephton CF, Cenik B, Cenik BK, Herz J, Yu G Biol. Chem. 2012 Jul 393 7 589-94
TDP-43 aggregation in neurodegeneration: are stress granules the key?
Dewey CM, Cenik B, Sephton CF, Johnson BA, Herz J, Yu G Brain Res. 2012 Jun 1462 16-25
Extracting ß-amyloid from Alzheimer's disease.
Dries DR, Yu G, Herz J Proc. Natl. Acad. Sci. U.S.A. 2012 Feb 109 9 3199-200

Honors & Awards

  • Award for Excellence in Postdoctoral Mentoring
  • Ruth K. Broad Research Foundation Award
  • Ruth Salta Junior Investigator Achievement Award
  • Alzheimer Disease Research Award
  • Natalie Ornish Award
  • Thomas O. Hicks Scholar in Medical Research
  • Memorial Frist/Jus Research Award

Professional Associations/Affiliations

  • American Society of Biochemistry and molecular biology (2010)
  • Editorial Board, Journal of Biological Chemistry (2010-2016)
  • Society for Neuroscience (2002)