Featured Publications
Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia.
Cenik B, Sephton CF, Dewey CM, Xian X, Wei S, Yu K, Niu W, Coppola G, Coughlin SE, Lee SE, Dries DR, Almeida S, Geschwind DH, Gao FB, Miller BL, Farese RV, Posner BA, Yu G, Herz J J. Biol. Chem. 2011 May 286 18 16101-8
TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.
Dewey CM, Cenik B, Sephton CF, Dries DR, Mayer P, Good SK, Johnson BA, Herz J, Yu G Mol. Cell. Biol. 2011 Mar 31 5 1098-108
Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes.
Sephton CF, Cenik C, Kucukural A, Dammer EB, Cenik B, Han Y, Dewey CM, Roth FP, Herz J, Peng J, Moore MJ, Yu G J. Biol. Chem. 2011 Jan 286 2 1204-15
Nicastrin functions as a gamma-secretase-substrate receptor.
Shah S, Lee SF, Tabuchi K, Hao YH, Yu C, LaPlant Q, Ball H, Dann CE, Südhof T, Yu G Cell 2005 Aug 122 3 435-47
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P Nature 2000 Sep 407 6800 48-54
Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.
Cenik B, Sephton CF, Kutluk Cenik B, Herz J, Yu G J. Biol. Chem. 2012 Sep 287 39 32298-306
TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration.
Sephton CF, Cenik B, Cenik BK, Herz J, Yu G Biol. Chem. 2012 Jul 393 7 589-94
TDP-43 aggregation in neurodegeneration: are stress granules the key?
Dewey CM, Cenik B, Sephton CF, Johnson BA, Herz J, Yu G Brain Res. 2012 Jun 1462 16-25
Extracting ß-amyloid from Alzheimer's disease.
Dries DR, Yu G, Herz J Proc. Natl. Acad. Sci. U.S.A. 2012 Feb 109 9 3199-200
{gamma}-Secretase-regulated Proteolysis of the Notch Receptor by Mitochondrial Intermediate Peptidase.
Lee SF, Srinivasan B, Sephton CF, Dries DR, Wang B, Yu C, Wang Y, Dewey CM, Shah S, Jiang J, Yu G J. Biol. Chem. 2011 Aug 286 31 27447-53
