Gang Yu, Ph.D.

• Alzheimer disease
• Neurodegeneration
• Neuroscience

 Featured Publications

Midkine attenuates amyloid-β fibril assembly and plaque formation.

Zaman M, Yang S, Huang Y, Yarbro JM, Hao Y, Wang Z, Liu D, Harper KE, Soliman H, Hemphill A, Harvey S, Pruett-Miller SM, Stewart V, Tanwar AS, Kalathur R, Grace CR, Turk M, Chittori S, Jiao Y, Wu Z, High AA, Wang X, Serrano GE, Beach TG, Yu G, Yang Y, Chen PC, Peng J, Nat Struct Mol Biol 2025 Aug

Proteomic landscape of Alzheimer's disease: emerging technologies, advances and insights (2021 - 2025).

Yarbro JM, Shrestha HK, Wang Z, Zhang X, Zaman M, Chu M, Wang X, Yu G, Peng J, Mol Neurodegener 2025 Jul 20 1 83

Human and mouse proteomics reveals the shared pathways in Alzheimer's disease and delayed protein turnover in the amyloidome.

Yarbro JM, Han X, Dasgupta A, Yang K, Liu D, Shrestha HK, Zaman M, Wang Z, Yu K, Lee DG, Vanderwall D, Niu M, Sun H, Xie B, Chen PC, Jiao Y, Zhang X, Wu Z, Chepyala SR, Fu Y, Li Y, Yuan ZF, Wang X, Poudel S, Vagnerova B, He Q, Tang A, Ronaldson PT, Chang R, Yu G, Liu Y, Peng J, Nat Commun 2025 Feb 16 1 1533

Cytoplasmic retention of the DNA/RNA-binding protein FUS ameliorates organ fibrosis in mice.

Chiusa M, Lee YA, Zhang MZ, Harris RC, Sherrill T, Lindner V, Brooks CR, Yu G, Fogo AB, Flynn CR, Zienkiewicz J, Hawiger J, Zent R, Pozzi A, J Clin Invest 2024 Mar 134 6

Alzheimer's disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment.

Chen PC, Han X, Shaw TI, Fu Y, Sun H, Niu M, Wang Z, Jiao Y, Teubner BJW, Eddins D, Beloate LN, Bai B, Mertz J, Li Y, Cho JH, Wang X, Wu Z, Liu D, Poudel S, Yuan ZF, Mancieri A, Low J, Lee HM, Patton MH, Earls LR, Stewart E, Vogel P, Hui Y, Wan S, Bennett DA, Serrano GE, Beach TG, Dyer MA, Smeyne RJ, Moldoveanu T, Chen T, Wu G, Zakharenko SS, Yu G, Peng J, Nat Aging 2022 Oct 2 10 923-940

Breathing new life into the rational design of Alzheimer's therapeutics.

Dries DR, Yu G, Cell 2021 Jan 184 2 296-298

Essential requirement for nicastrin in marginal zone and B-1 B cell development.

Choi JH, Han J, Theodoropoulos PC, Zhong X, Wang J, Medler D, Ludwig S, Zhan X, Li X, Tang M, Gallagher T, Yu G, Beutler B, Proc. Natl. Acad. Sci. U.S.A. 2020 Feb

Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.

Bai B, Wang X, Li Y, Chen PC, Yu K, Dey KK, Yarbro JM, Han X, Lutz BM, Rao S, Jiao Y, Sifford JM, Han J, Wang M, Tan H, Shaw TI, Cho JH, Zhou S, Wang H, Niu M, Mancieri A, Messler KA, Sun X, Wu Z, Pagala V, High AA, Bi W, Zhang H, Chi H, Haroutunian V, Zhang B, Beach TG, Yu G, Peng J, Neuron 2020 Jan

Low levels of NMNAT2 compromise axon development and survival.

Gilley J, Mayer P, Yu G, Coleman MP Hum. Mol. Genet. 2018 Oct

Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency.

Evers BM, Rodriguez-Navas C, Tesla RJ, Prange-Kiel J, Wasser CR, Yoo KS, McDonald J, Cenik B, Ravenscroft TA, Plattner F, Rademakers R, Yu G, White CL, Herz J Cell Rep 2017 Sep 20 11 2565-2574

• Award for Excellence in Postdoctoral Mentoring
  (2010)
• Ruth K. Broad Research Foundation Award
  (2006)
• Ruth Salta Junior Investigator Achievement Award
  (2005)
• Alzheimer Disease Research Award
  (2003)
• Natalie Ornish Award
  (2002)
• Thomas O. Hicks Scholar in Medical Research
  (2001)
• Memorial Frist/Jus Research Award
  (1998)

• American Society of Biochemistry and molecular biology (2010)
• Editorial Board, Journal of Biological Chemistry (2010-2016)
• Society for Neuroscience (2002)