Kim Orth, Ph.D. Titles and Appointments Professor Endowed Title Earl A. Forsythe Chair in Biomedical Science; W. W. Caruth, Jr. Scholar in Biomedical Research School Medical School Department Molecular Biology | Biochemistry Graduate Programs Biological Chemistry, Molecular Microbiology Biography Download Curriculum Vitae Kim Orth Investigator, HHMI Professor, Department of Molecular Biology HHMI, University of Texas Southwestern Medical Center 5323 Harry Hines Blvd. Room# NA5-120F, Dallas, Texas, 75390-9148. email: kim.orth@utsouthwestern.edu Office Phone: 214-648-1685; FAX: 214-648-1488 Personal Statement Dr. Kim Orth is a biochemist that received her bachelor in biochemistry from Texas A &M University, masters in biological chemistry from UCLA and PhD in biochemistry from UT Southwestern Medical Center. While becoming the mother of two, she did multiple productive postdoctoral fellowships at University of Michigan studying mismatch repair with ovarian cancer, apoptosis, cellular signal transduction, enzymology and finally host/pathogen interactions. She is recognized for her elucidation of novel biochemical mechanisms that bacterial effectors use to modify host proteins including Ser/Thr acetylation and AMPylation. The repertoire of tools she used to decipher these novel activities allowed her to continue studies on metazoan AMPylation in model organisms, including flies and mice, where her lab ultimately created a pre-clinical murine model for neonatal diabetes that is caused by an analogous mutation in AMPylation machinery found in humans. Her lab continues to discover new biology and signaling pathways, including transertion, from bacterial pathogens. In 2001, she joined the faculty in the Department of Molecular Biology at UT Southwestern Medical Center where she is currently a professor. In 2015, Orth became an Investigator for the Howard Hughes Medical Institute. Orth has many awards including the Arnold and Mabel Beckman Young Investigator Award, Burroughs Wellcome Investigator in Pathogenesis of Infectious Disease and Welch Foundation Norman Hackerman Award in Chemical Science. In 2018, she received the ASBMB Merck Award (2018) and wrote a solicited, personal reflection on her path in science for the Journal of Biological Chemistry to provide tools for younger scientists. Orth is a member of the American Academy of Microbiology, The Academy of Medicine, Engineering and Science of Texas, American Association for the Advancement of Science, and of the National Academy of Sciences. Education Undergraduate Texas A&M University (1984), Biochemistry Graduate School Uni of California (UCLA) (1986), Biochemistry Graduate School Univ of Tx Southwestern Med Ct (1993), Molecular Biology Research Interest Biochemistry Cellular Signaling Molecular Microbiology Publications Featured Publications Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress. Chimalapati S, de Souza Santos M, Lafrance AE, Ray A, Lee WR, Rivera-Cancel G, Vale G, Pawlowski K, Mitsche MA, McDonald JG, Liou J, Orth K, Elife 2020 08 9 A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM. Peng W, Casey AK, Fernandez J, Carpinone EM, Servage KA, Chen Z, Li Y, Tomchick DR, Starai VJ, Orth K, Nat. Struct. Mol. Biol. 2020 May My winding trail while fulfilling my love for science and family. Orth K J. Biol. Chem. 2018 Jul 293 27 10435-10437 Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies. Casey AK, Moehlman AT, Zhang J, Servage KA, Krämer H, Orth K J. Biol. Chem. 2018 Feb 293 5 1550 Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration. Moehlman AT, Casey AK, Servage K, Orth K, Krämer H. eLife 2018 17;7. pii: e38752. doi: 10.7554/eLife.38752. [Epub ahead of print] Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies. Casey AK, Moehlman AT, Zhang J, Servage KA, Krämer H, Orth K J. Biol. Chem. 2017 12 292 51 21193-21204 Bile salt receptor complex activates a pathogenic type III secretion system. Li P, Rivera-Cancel G, Kinch LN, Salomon D, Tomchick DR, Grishin NV, Orth K Elife 2016 5 AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. Yarbrough, M., Li, Y., Kinch, L.N., Grishin, N.V., Hall B.E., & Orth, K. Science January 2009 323 269-272 Co-component signal transduction systems: Fast-evolving virulence regulation cassettes discovered in enteric bacteria. Kinch LN, Cong Q, Jaishankar J, Orth K, Proc Natl Acad Sci U S A 2022 Jun 119 24 e2203176119 Beth Levine M.D. Prize in Autophagy Research. Vitetta ES, Cobb MH, Hobbs HH, Hooper L, Morrison SJ, Orth K, Pfeiffer J, Rosen MK, Takahashi JS, Wang T, Autophagy 2021 Aug 1 Results 1-10 of 92 1 2 3 4 5 Next Last Honors & Awards American Association for the Advancement of Science (2022) ASBMBFellow (2022) American Society of Microbiology Distinguish Lecturer (2021-2023) Elected to the National Academy of Sciences (2020) The Academy of Medicine, Engineering and Science of TexasMember (2020) Nirit and Michael Shaoul Visiting Scholar, Tel Aviv University (2019) ASBMB Merck Award (2018) American Academy of MicrobiologyFellow (2016) HHMIInvestigator (2015) Earl A. Forsythe Chair in Biomedical Science (2013) ASBMB Young Investigator Award (2012) TAMEST; 2011 Edith & Peter O'Donnell Award in Science (2011) The Welch Foundation Norman Hackerman Award in Chemical Research (2010) Burroughs Wellcome Investigator in Pathogenesis of Infectious Disease (2006) Arnold and Mabel Beckman Young Investigator Award (2003) W.W. Caruth, Jr. Scholar in Biomedical Research, UTSWMC (2001) Professional Associations/Affiliations ASBMB (2002) ASCB (2006) ASM (2006) NAS (2020) TAMEST (2020)
