Dr. Edaire Cheng obtained her BS degree from Rice University (2001) and her MD degree from University of Texas Southwestern Medical School (2005). She completed her residency in pediatric medicine (2008) and her fellowship in pediatric gastroenterology (2011) at University of Texas Southwestern Medical Center/Children’s Medical Center in Dallas.  

Dr. Cheng’s clinical interests include eosinophilic esophagitis, gastroesophageal reflux disease, and eosinophilic gastrointestinal disease. Her research interests include understanding the mechanisms of eosinophilic infiltration and tissue remodeling in the esophagus.


Medical School
UT Southwestern Medical School (2005)
UT Southwestern/Children's Medical Center (2008), Pediatrics
UT Southwestern/Children's Medical Center (2011), Pediatric Gastroenterology

Specialty Areas

Clinical Interest

  • Eosinophilic Esophagitis
  • Eosinophilic Gastrointestinal Disease
  • Gastroesophageal Reflux (GERD) - Heartburn
  • Gastrointestinal Fibrosis
  • Research Interest

    • Eotaxin-3 expression in eosinophilic esophagitis and GERD
    • Therapeutic agents for eosinophilic esophagitis
    • Tissue remodeling and fibrosis in eosinophilic esophagitis


    Featured Publications LegendFeatured Publications

    Aspirin prevents NF-?B activation and CDX2 expression stimulated by acid and bile salts in oesophageal squamous cells of patients with Barrett's oesophagus.
    Huo X, Zhang X, Yu C, Cheng E, Zhang Q, Dunbar KB, Pham TH, Lynch JP, Wang DH, Bresalier RS, Spechler SJ, Souza RF Gut 2017 Apr
    Hypoxia-inducible factor-2a plays a role in mediating oesophagitis in GORD.
    Huo X, Agoston AT, Dunbar KB, Cipher DJ, Zhang X, Yu C, Cheng E, Zhang Q, Pham TH, Tambar UK, Bruick RK, Wang DH, Odze RD, Spechler SJ, Souza RF Gut 2016 Sep
    NOD-Like Receptor Protein 3 Inflammasome Priming and Activation in Barrett's Epithelial Cells.
    Nadatani Y, Huo X, Zhang X, Yu C, Cheng E, Zhang Q, Dunbar KB, Theiss A, Pham TH, Wang DH, Watanabe T, Fujiwara Y, Arakawa T, Spechler SJ, Souza RF Cell Mol Gastroenterol Hepatol 2016 Jul 2 4 439-453
    Eosinophilic esophagitis: current perspectives from diagnosis to management.
    Moawad FJ, Cheng E, Schoepfer A, Al-Haddad S, Bellizzi AM, Dawson H, El-Zimaity H, Guindi M, Penagini R, Safrooneva E, Chehade M Ann. N. Y. Acad. Sci. 2016 Jul
    Significance of Paneth Cells in Histologically Unremarkable Rectal Mucosa.
    Pezhouh MK, Cheng E, Weinberg AG, Park JY Am. J. Surg. Pathol. 2016 Feb
    JAK-STAT6 Pathway Inhibitors Block Eotaxin-3 Secretion by Epithelial Cells and Fibroblasts from Esophageal Eosinophilia Patients: Promising Agents to Improve Inflammation and Prevent Fibrosis in EoE.
    Cheng E, Zhang X, Wilson KS, Wang DH, Park JY, Huo X, Yu C, Zhang Q, Spechler SJ, Souza RF PLoS ONE 2016 11 6 e0157376
    Mitochondrial STAT3 Contributes to Transformation of Barrett's Epithelial Cells that Express Oncogenic Ras in a p53-Independent Fashion.
    Yu C, Huo X, Agoston AT, Zhang X, Theiss AL, Cheng E, Zhang Q, Zaika A, Pham TH, Wang DH, Lobie PE, Odze RD, Spechler SJ, Souza RF Am. J. Physiol. Gastrointest. Liver Physiol. 2015 Jun ajpgi.00462.2014
    In oesophageal squamous cells, nitric oxide causes S-nitrosylation of Akt and blocks SOX2 (sex determining region Y-box 2) expression.
    Asanuma K, Huo X, Agoston A, Zhang X, Yu C, Cheng E, Zhang Q, Dunbar KB, Pham TH, Wang DH, Iijima K, Shimosegawa T, Odze RD, Spechler SJ, Souza RF Gut 2015 May
    Translating New Developments in Eosinophilic Esophagitis Pathogenesis into Clinical Practice.
    Cheng E Curr Treat Options Gastroenterol 2015 Jan
    Eosinophilic Esophagitis: Interactions with Gastroesophageal Reflux Disease.
    Cheng E, Souza RF, Spechler SJ Gastroenterol. Clin. North Am. 2014 Jun 43 2 243-256


    Featured Books Legend Featured Books

    Honors & Awards

    • Research Scholar Award
      American Gastroenterological Association (2013)
    • First Place Award - Research Poster Presentation
      Dallas VA Medical Center Research Week (2012)
    • NASPGHAN Foundation/AstraZeneca Award
      for Disorders of the Upper Gastrointestinal Tract (2012)
    • Distinguished Achievement Award - North American Conference of Gastroenterology Fellows
      Abstract and Travel Award (2011)
    • Fellowship2Leadership Gastroenterology/Hepatology Fellows' Travel Grant
      Travel Award (2010)
    • Gastroenterology Research Group Fellows Travel Award
      Abstract and Travel Award (2010)
    • SWMS Dean's Competitive Scholarship
      UT Southwestern Medical School (2002-2004)
    • Magna Cum Laude
    • Medical Center Woman's Club Scholarship
      UT Southwestern Medical School (2001-2002)
    • UTSW Alumni Scholarship Program
      UT Southwestern (2001-2003)

    Professional Associations/Affiliations

    • American Gastroenterological Association Women's Committee (2015)
    • American Gastroenterological Association (2009)
    • Gastroenterology Research Group (2009)
    • North American Society of Pediatric Gastroenterology and Nutrition (2008)