Alagarraju Muthukumar, Ph.D.

     

Dr. Kumar has a Masters and PhD in Biochemistry. He has completed clinical fellowships in clinical chemistry and molecular diagnostics at UT Southwestern Medical Center in Dallas. He had worked in the clinical diagnostic industry for 4 years before moving back to academia. He is a board certified Clinical chemist, and is currently the Medical Director of Clinical Chemistry at the Clements University Hospital, Zale Lipshy University hospital, Simmons Comprehensive Cancer Center, Moncrief Cancer Institute in Fort Worth, and the UT Southwestern Clinics in Plano and Richardson.

His research interests include validating new diagnostic assays, repurposing big data for clinical research, and finding new applications for existing diagnostic markers. Current ongoing projects in his labs include the assessment of humoral immune response to SARS-CoV-2 vaccines and a collaboration with Johns Hopkins University on the evaluation of clinical implications of LDL under-estimation in Coronary Heart Disease patients.

Medical School

Madras University Medical School (1996)

Other Post Graduate Training

Foreign Credentials Service of America (1996)

Graduate School

Foreign Credentials Service of America (1996)

Fellowship

UT Southwestern Medical Center (2006)

Fellowship

UT Southwestern Medical Center (2007)

• Repurposing of big data for clinical research
• Validation of new diagnostic assays

Featured Publications

Comparison of Sampson and extended Martin/Hopkins methods of low-density lipoprotein cholesterol calculations with direct measurement in pediatric patients with hypertriglyceridemia.

Islam SMT, Muthukumar AR, Jones PM, Hashim I, Cao J Lab Med 2023

SARS-CoV-2 Vaccination IgG Antibody Responses in Patients with Hematologic Malignancies in a Myeloid Enriched Cohort: A Single Center Observation.

Hoff FW, Goksu SY, Premnath N, Patel PA, Ikpefan R, Kaur G, Vusirikala M, Bat T, Chen W, Geethakumari PR, Anderson LD Jr, Awan FT, Collins RH, Weinberg OK, Muthukumar A, Chung SS, Madanat YF. Acta Med Acad. 2023

Crossroads between Autoimmunity and COVID-19 in Lung Transplant Recipients.

Narasimhan M, Muthukumar AR, Sataranatarajan K, Mahimainathan L, Mahan L, Timofte I, Bollineni S, Joerns J, Zhang S, Gorman A, Banga A, Mohanka M, Torres F, Lawrence A, Thalachallour M, Kaza V. Viruses. 2023

Post-acute sequelae of COVID-19 and longitudinal antibody levels in a community-based cohort.

Kopplin N, Garcia A, Reczek A, Wilkinson K, Yekkaluri S, Murphy CC, Tiro J, Muthukumar AR, Masica A, Singal AG. PLoS One. 2023

‘Real-World’ Impact of Tixagevimab/Cilgavimab (Evusheld) on COVID-19 Outcomes in Patients Undergoing Cellular Therapies.

Sannareddy A, Reves H, Narasimhan M, Jaleta K, Anderson JM, Patel H, Anderson Jr. LD, Afrough A, Chung S, Collins RH, Kaur G, Kumar KA, Madanat YF, Vusirikala M, Awan FT, Muthukumar AR, Geethakumari PR. Transplant Cell Ther 2023

Methods of Low-Density Lipoprotein-Cholesterol Measurement: Analytical and Clinical Applications.

Islam SMT, Osa-Andrews B, Jones PM, Muthukumar AR, Hashim I, Cao J, EJIFCC 2022 Dec 33 4 282-294

Ivabradine toxicity: a case report.

Singh K, Alagarraju MR, Wolf CE, Poklis JL, Kulkarni N, Tharpe W, Joshi PH, J Med Case Rep 2022 Oct 16 1 392

Multiplex Fragment Analysis for Flexible Detection of All SARS-CoV-2 Variants of Concern.

Clark AE, Wang Z, Ostman E, Zheng H, Yao H, Cantarel B, Kanchwala M, Xing C, Chen L, Irwin P, Xu Y, Oliver D, Lee FM, Gagan JR, Filkins L, Muthukumar A, Park JY, Sarode R, SoRelle JA, Clin Chem 2022 May

SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics.

Ramachandran K, Maity S, Muthukumar AR, Kandala S, Tomar D, Abd El-Aziz TM, Allen C, Sun Y, Venkatesan M, Madaris TR, Chiem K, Truitt R, Vishnu N, Aune G, Anderson A, Martinez L, Yang W, Stockand JD, Singh BB, Srikantan S, Reeves WB, Madesh M, iScience 2022 Jan 25 1 103722

Translation suppression underlies the restrained COVID-19 mRNA vaccine response in the high-risk immunocompromised group.

Kim K, Narasimhan M, Mahimainathan L, Zhang R, Araj E, Kim E, Tharpe W, Greenberg BM, Greenberg DE, Li QZ, Cheng CA, Sarode R, Malladi S, Muthukumar A, Front Immunol 2022 13 1020165

• Best Poster Finalist
  Systematic Analysis of Biotin Interference in Roche Chemistry Assays. ASCP 2017 Annual Meeeting, Chicago, IL. September 6-8, 2017
• Best Poster Finalist
  Are all creatinine results suspect during Dopamine and Debutamine infusions? ASCP 2017 Annual Meeeting, Chicago, IL. September 6-8, 2017
• Distinguished Abstract award
  Susceptability of High Sensitivity Cardiac Troponin I and Gen 5 cTnT assays to Biotin interference. 70th AACC Annual Meeting, Chicago, IL. July 29 - August 2, 2018

• American Association of Clinical Chemistry (2005)
• American Society for Clinical Pathology (2015)