Alagarraju “Kumar” Muthukumar, Ph.D. Titles and Appointments Associate Professor School Medical School Department Pathology Biography Dr. Kumar has a Masters and PhD in Biochemistry. He has completed clinical fellowships in clinical chemistry and molecular diagnostics at UT Southwestern Medical Center in Dallas. He worked in the clinical diagnostic industry for 4 years before moving back to academia. He is a board certified Clinical chemist, and is currently the Medical Director of Clinical Chemistry at the Clements University Hospital, Zale Lipshy University hospital, Simmons Comprehensive Cancer Center, Moncrief Cancer Institute in Fort Worth, and the UT Southwestern Clinics in Plano and Richardson. His research interests include validating new diagnostic assays, repurposing big data for clinical research, and finding new applications for existing diagnostic markers. Various ongoing projects in his labs include the assessment of adverse immune responses in patients enrolled in Gene Therapy trials, evaluation of the effectiveness of current clinical decision pathways utilized in the rapid rule-in and rule-out of acute myocardial infarction in ED chest pain patients, ascertaining a role for albumin adjusted Calcium in clinical care, and a collaboration with Johns Hopkins University on the evaluation of clinical implications of LDL under-estimation in Coronary Heart Disease patients. Education Medical School Madras University Medical School (1996) Other Post Graduate Training Foreign Credentials Service of America (1996) Graduate School Foreign Credentials Service of America (1996) Fellowship UT Southwestern Medical Center (2006) Fellowship UT Southwestern Medical Center (2007) Research Interest Repurposing of big data for clinical research Validation of new diagnostic assays Publications Featured Publications First-in-human high dose AAV9 intrathecal gene therapy for paediatric CLN7 disease: a phase 1, open-label, single ascending dose, non-randomised clinical trial. Greenberg BM, Minassian B, Messahel S, Edgar VB, Lowden A, Dahshi H, Nettesheim ER, Nguyen HH, Hughes S, Muthukumar AR, Srinivasan K, Iannaccone S, Varadarajan G, Gray SJ, Kayani SN, EBioMedicine 2025 Nov 123 106044 Revisiting High-Sensitivity Cardiac Troponin Abnormal Baseline Cutoffs: Implications for AMI Diagnosis in the Emergency Department. Sataranatarajan K, Narasimhan M, Chuckaree ID, Balani J, Zhang R, Vigen R, Muthukumar A, J Clin Med 2025 Oct 14 20 Modern Low-Density Lipoprotein Cholesterol Formulas Outperform Direct Methods in Patients with Hypertriglyceridemia and Low Levels of Low-Density Lipoprotein Cholesterol. Meeusen JW, Yi X, Cotten SW, Nielsen JB, Donato LJ, Jones PM, Muthukumar AR, Zubirán R, Remaley AT, Cao J, Clin Chem 2025 Sep Navigating an unexpected creatinine result during a pre-intravenous contrast renal function workup. Narasimhan M, Smith K, Muthukumar A, Clin Biochem 2025 Jul 139 110979 SARS-CoV-2 vaccine failure rates and predictors of immune response in a diverse immunocompromised patient population. Greenberg BM, Minna JD, Gerber DE, Hernandez RS, Monson N, Muthukumar A, Cassady K, Chio E, Hooper AT, Wipperman MF, Greenberg DE, Vaccine 2025 Jul 62 127473 Increase in Lipoprotein (a) Screening and Utilization at an Urban Academic Medical Center. Wong W, Kao C, Schneider R, Muthukumar A, Navar AM, Rohatgi A, Khera A, Joshi P, Am J Cardiol 2025 Mar Fatigued with Friedewald: why isn't everyone onboard yet with the new LDL-C equations? Narasimhan M, Cao J, Meeusen JW, Remaley AT, Martin SS, Muthukumar A, Front Cardiovasc Med 2025 12 1534460 Performance Evaluation of Open Channel Buhlmann Fecal Calprotectin Turbo Assay on Abbott Alinity C Analyzer. Sataranatarajan K, Adhikari S, Nguyen N, Narasimhan M, Balani J, Muthukumar A, Diagnostics (Basel) 2024 Aug 14 16 Recent Recall of Iron Reagent-Investigation of Potential Reagent Contamination and Assay Improvement Strategy. Narasimhan M, Jaleta K, Adhikari S, Berihun M, SataraNatarajan K, Mahimainathan L, Cao J, Jones PM, Hashim I, Muthukumar AR, J Appl Lab Med 2024 Jul Comparison of Sampson and extended Martin/Hopkins methods of low-density lipoprotein cholesterol calculations with direct measurement in pediatric patients with hypertriglyceridemia. Islam SMT, Muthukumar AR, Jones PM, Hashim I, Cao J Lab Med 2023 Results 1-10 of 61 1 2 3 4 5 Next Last Honors & Awards Best Poster FinalistSystematic Analysis of Biotin Interference in Roche Chemistry Assays. ASCP 2017 Annual Meeeting, Chicago, IL. September 6-8, 2017 Best Poster FinalistAre all creatinine results suspect during Dopamine and Debutamine infusions? ASCP 2017 Annual Meeeting, Chicago, IL. September 6-8, 2017 Distinguished Abstract awardSusceptability of High Sensitivity Cardiac Troponin I and Gen 5 cTnT assays to Biotin interference. 70th AACC Annual Meeting, Chicago, IL. July 29 - August 2, 2018 Professional Associations/Affiliations American Association of Clinical Chemistry (2005) American Society for Clinical Pathology (2015)
