The focus of my research is the comprehensive study of non-alcoholic fatty liver disease (NAFLD) in humans. The overarching goal is to understand the metabolic derangements that lead to this disease through the application of advanced imaging and metabolic techniques. Translating these basic science techniques to the clinical realm allows for a more complete understanding of the pathophysiology of NAFLD and extension of this understanding through complimentary studies utilizing traditional clinical research tools (epidemiology, retrospective and prospective studies, and clinical trials). In addition to the knowledge gained, this approach allows for the development of novel therapeutic and diagnostic modalities in a logical, disease- and patient-oriented manner.
My initial interest in metabolism began during medical school when I participated in nuclear magnetic resonance (NMR) studies using a variety of stable isotope tracers to investigate glycolysis in rats. As a result of my initial work, I have returned to the group at the Advanced Imaging Research Center (AIRC), becoming proficient in the application of high-field NMR spectroscopy and stable isotopes to track metabolic pathways in humans. The primary goal of my research is to create an integrated approach to the study of hepatic glucose and lipid metabolism that allows for multiple simultaneous metabolic flux measurements to be made. We have already applied these techniques in rodents as well as humans (with and without NAFLD) under a variety of conditions.
It is my view that disease-oriented research should be comprehensive in nature, exploiting available basic science modalities to enhance our understanding of the pathophysiology of a disease while simultaneously translating this new-found knowledge into the clinical realm. This allows for a focused and logical approach to the study of a disease, an approach that has a high likelihood of impacting clinical practice and improving patient care.
- Medical School
- UT Southwestern Medical Center (1998)
- University of Alabama of Birmingham (1999), Internal Medicine
- University of Alabama of Birmingham (2001), Internal Medicine
- UT Southwestern Medical Center (2004), Gastroenterology
- Adiponectin as an independent predictor of the presence and degree of hepatic steatosis in the dallas heart study.
- Turer AT, Browning JD, Ayers CR, Das SR, Khera A, Vega GL, Grundy SM, Scherer PE J. Clin. Endocrinol. Metab. 2012 Jun 97 6 E982-6
- Use of 2H2O for estimating rates of gluconeogenesis: determination and correction of error due to transaldolase exchange
- Browning JD, Burgess SC Am J Physiol Endocrinol Metab 2012 303 11 E1304-12
- Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease.
- Sunny NE, Parks EJ, Browning JD, Burgess SC Cell Metab. 2011 Dec 14 6 804-10
- Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction.
- Browning JD, Baker JA, Rogers T, Davis J, Satapati S, Burgess SC Am. J. Clin. Nutr. 2011 May 93 5 1048-52
- The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men.
- Browning JD, Baxter J, Satapati S, Burgess SC J. Lipid Res. 2011 Dec
- Hepatic triglyceride content in individuals with reduced intestinal cholesterol absorption due to variants in Nieman Pick C1-like 1.
- Ramirez R, Cohen JC, Hobbs HH, Browning JD Hepatology 2011 Aug 54 2 736-7
- T(2) measurement of J-coupled metabolites in the human brain at 3T.
- Ganji SK, Banerjee A, Patel AM, Zhao YD, Dimitrov IE, Browning JD, Sherwood Brown E, Maher EA, Choi C NMR Biomed 2011 Aug
- Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans.
- Browning JD, Horton JD J. Lipid Res. 2010 Nov 51 11 3359-63
- Patatin-like phospholipase domain-containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease.
- Browning JD, Cohen JC, Hobbs HH Hepatology 2010 Oct 52 4 1189-92
- Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet.
- Sunny NE, Satapati S, Fu X, He T, Mehdibeigi R, Spring-Robinson C, Duarte J, Potthoff MJ, Browning JD, Burgess SC Am. J. Physiol. Endocrinol. Metab. 2010 Jun 298 6 E1226-35
Gallstone Disease. In Sleisinger & Fordtran's Gastrointestinal and Liver Disease, 8th edition
Browning JD, Sreenarasimhaiah J (2006). Philadelphia, Saunders
Honors & Awards
- Holder, Lancaster Family Fund in Gastroenterology
University of Texas Southwestern Medical School, Dallas, TX (2010)
- Disease Oriented Clinical Scholar (DOCS)
University of Texas Southwestern Medical School, Dallas, TX (2006)
American Board of Internal Medicine, Gastroenterology (2005)
- Research Excellence in GI and Liver (REGAL) Award
University of Kansas Medical Center / Janssen Pharmaceutica / Centocor / Ortho-Biotech Products (2005)
- NIH Training Fellowship
- Postdoctoral Fellowship
American Liver Foundation (2003)
American Board of Internal Medicine (2001)
- Ben Friedman Award for excellence in teaching
University of Alabama, Birmingham, Birmingham, AL (2001)
- Ben Friedman Award for excellence in teaching
University of Alabama, Birmingham, Birmingham, AL (1998)
- Medical Director (2010)