Biography

The focus of my research is the comprehensive study of non-alcoholic fatty liver disease (NAFLD) in humans. The overarching goal is to understand the metabolic derangements that lead to this disease through the application of advanced imaging and metabolic techniques. Translating these basic science techniques to the clinical realm allows for a more complete understanding of the pathophysiology of NAFLD and extension of this understanding through complimentary studies utilizing traditional clinical research tools (epidemiology, retrospective and prospective studies, and clinical trials). In addition to the knowledge gained, this approach allows for the development of novel therapeutic and diagnostic modalities in a logical, disease- and patient-oriented manner.

My initial interest in metabolism began during medical school when I participated in nuclear magnetic resonance (NMR) studies using a variety of stable isotope tracers to investigate glycolysis in rats. As a result of my initial work, I have returned to the group at the Advanced Imaging Research Center (AIRC), becoming proficient in the application of high-field NMR spectroscopy and stable isotopes to track metabolic pathways in humans. The primary goal of my research is to create an integrated approach to the study of hepatic glucose and lipid metabolism that allows for multiple simultaneous metabolic flux measurements to be made. We have already applied these techniques in rodents as well as humans (with and without NAFLD) under a variety of conditions.

It is my view that disease-oriented research should be comprehensive in nature, exploiting available basic science modalities to enhance our understanding of the pathophysiology of a disease while simultaneously translating this new-found knowledge into the clinical realm. This allows for a focused and logical approach to the study of a disease, an approach that has a high likelihood of impacting clinical practice and improving patient care.

Education

Undergraduate University of Texas at Austin (1994), Biochemistry
Medical School University of Texas Southwestern Med Ctr Dallas (1998), Medicine

Publications

Featured Publications LegendFeatured Publications

The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men.

Browning JD, Baxter J, Satapati S, Burgess SC J. Lipid Res. 2011 Dec

Hepatic triglyceride content in individuals with reduced intestinal cholesterol absorption due to variants in Nieman Pick C1-like 1.

Ramirez R, Cohen JC, Hobbs HH, Browning JD Hepatology 2011 Aug 54 2 736-7

T(2) measurement of J-coupled metabolites in the human brain at 3T.

Ganji SK, Banerjee A, Patel AM, Zhao YD, Dimitrov IE, Browning JD, Sherwood Brown E, Maher EA, Choi C NMR Biomed 2011 Aug

Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans.

Browning JD, Horton JD J. Lipid Res. 2010 Nov 51 11 3359-63

Patatin-like phospholipase domain-containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease.

Browning JD, Cohen JC, Hobbs HH Hepatology 2010 Oct 52 4 1189-92

Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet.

Sunny NE, Satapati S, Fu X, He T, Mehdibeigi R, Spring-Robinson C, Duarte J, Potthoff MJ, Browning JD, Burgess SC Am. J. Physiol. Endocrinol. Metab. 2010 Jun 298 6 E1226-35

Books

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Honors & Awards

  • Holder, Lancaster Family Fund in Gastroenterology
    University of Texas Southwestern Medical School, Dallas, TX (2010)
  • Disease Oriented Clinical Scholar (DOCS)
    University of Texas Southwestern Medical School, Dallas, TX (2006)
  • Diplomate
    American Board of Internal Medicine, Gastroenterology (2005)
  • Research Excellence in GI and Liver (REGAL) Award
    University of Kansas Medical Center / Janssen Pharmaceutica / Centocor / Ortho-Biotech Products (2005)
  • NIH Training Fellowship
    NIH (2003)
  • Postdoctoral Fellowship
    American Liver Foundation (2003)
  • Diplomate
    American Board of Internal Medicine (2001)
  • Ben Friedman Award for excellence in teaching
    University of Alabama, Birmingham, Birmingham, AL (2001)
  • Ben Friedman Award for excellence in teaching
    University of Alabama, Birmingham, Birmingham, AL (1998)

Professional Associations/Affiliations

  • Medical Director (2010)