Dr. Craig M. Powell earned both his M.D. with honor and Ph.D. in Neuroscience research at Baylor College of Medicine in 1994 and 1997 respectively. His graduate work with Drs. David Sweatt and Dan Johnston was among the first studies to measure lasting biochemical changes during long-lasting synaptic plasticity in the hippocampus. After his Medical Internship year at Baylor College of Medicine, Dr. Powell trained at the University of California, San Francisco Neurology Residency Program. In his final year, Dr. Powell was chosen to be the Chief Resident in the UCSF Neurology Program. Dr. Powell was elected to Phi Beta Kappa as an undergraduate as well as to Alpha Omega Alpha medical Honor society in medical school.
Currently, Dr. Powell is the Ed and Sue Rose Distinguished Professor in Neurology, a tenured Professor at The University of Texas Southwestern Medical Center's Depts. of Neurology & Neurotherapeutics, Psychiatry, and Neuroscience and an active member of the Neuroscience Graduate Program. His translational laboratory research program is focused on the molecular mechanisms of learning and memory, synaptic plasticity, and neuropsychiatric disorders such as autism, intellectual disability, and Alzheimer’s. Dr. Powell's clinical Neurology practice is on the inpatient and outpatient Neurology services at the University Hospitals and Parkland Memorial Hospital. Dr. Powell also supervises and teaches Neurology Residents at the Parkland Memorial Hospital outpatient clinics.
- Graduate School
- Baylor College of Medicine (1994), Neuroscience
- Medical School
- Baylor College of Medicine (1997)
- Baylor College of Medicine/The Methodist Hospital (1998), Transitional Year
- University of California at San Francisco (2001), Child Neurology
- Alzheimer's Disease: Translational Research for Prevention and Treatment
- Autism: Mechanisms and Future Treatment
- Mental Retardation Syndromes
- Molecular Basis of Neuropsychiatric Disease
- Molecular Mechanisms of Learning, Memory, & Synaptic Plasticity
- Kctd13 deletion reduces synaptic transmission via increased RhoA
- Escamilla, C. O., Filonova, I., Walker, A. K., Xuan, Z., Liu, S., Summer, T.B., Lopez-Garcia, I.A., Usui, N., Ellegood, J., Eisch, A.J., Konopka, G., Lerch, J.P., Schier, A.F., Speed, H.E., & Powell, C.M. Nature 2017 in press
- PTEN knockdown alters dendritic spine/protrusion morphology, not density.
- Haws ME, Jaramillo TC, Espinosa-Becerra F, Widman A, Stuber GD, Sparta DR, Tye KM, Russo SJ, Parada LF, Kaplitt M, Bonci A, Powell CM J. Comp. Neurol. 2013 Nov
- Loss of predominant shank3 isoforms results in hippocampus-dependent impairments in behavior and synaptic transmission.
- Kouser M, Speed HE, Dewey CM, Reimers JM, Widman AJ, Gupta N, Liu S, Jaramillo TC, Bangash M, Xiao B, Worley PF, Powell CM J. Neurosci. 2013 Nov 33 47 18448-68
- Block of glucocorticoid synthesis during re-activation inhibits extinction of an established fear memory.
- Blundell J, Blaiss CA, Lagace DC, Eisch AJ, Powell CM Neurobiol Learn Mem 2011 May 95 4 453-60
- Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury.
- Blaiss CA, Yu TS, Zhang G, Chen J, Dimchev G, Parada LF, Powell CM, Kernie SG J. Neurosci. 2011 Mar 31 13 4906-16
- RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia.
- Blundell J, Kaeser PS, Südhof TC, Powell CM J. Neurosci. 2010 Apr 30 15 5326-33
- Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior.
- Blundell J, Blaiss CA, Etherton MR, Espinosa F, Tabuchi K, Walz C, Bolliger MF, Südhof TC, Powell CM J. Neurosci. 2010 Feb 30 6 2115-29
- Neuroligin 1 Deletion Results in Impaired Spatial Memory and Increased Repetitive Behavior
- Blundell, J., Blaiss, C.A., Etherton, M.R., Espinosa, F., Tabuchi, K., Walz, C., Bolliger, M.F., Sudhof, T.C., & Powell, C.M. Journal of Neuroscience 2010 in press
- Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments.
- Etherton MR, Blaiss CA, Powell CM, Südhof TC Proc. Natl. Acad. Sci. U.S.A. 2009 Oct 106 42 17998-8003
- Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2.
- Blundell J, Tabuchi K, Bolliger MF, Blaiss CA, Brose N, Liu X, Südhof TC, Powell CM Genes Brain Behav. 2009 Feb 8 1 114-26
The Autisms: Molecules to Model Systems
Craig M. Powell & Lisa M. Monteggia (Ed.) (2013). New York, New York, Oxford University Press
Honors & Awards
- Elected Chair, Dept. of Defense Autism Research Program Integration Panel
- Director, Erma Lowe Center for Alzheimer's Research
- Elected Member ANA
- Elected Member ACNP
- ACNP Young Investigator Travel Award
- Autism Young Investigator Award--Neurobiology of Autism and Related Disorders
- NARSAD Young Investigator Award
National Alliance for Research on Schizophrenia and Depression basic research grant (2003)
- NIMH K08 Award
National Institute of Mental Health basic research grant (2003)
- Neurology Chief Resident--UCSF
- Alpha Omega Alpha
- American College of Neuropsychopharmacology
- American Neurological Association (ANA), American Academy of Neurology (AAN)
- International Society for Autism Research
- Molecular and Cellular Cognition Society
- Society for Neuroscience