Qinghua Liu, Ph.D.

Associate Professor

Endowed Title: W.A. "Tex" Moncrief Jr. Scholar in Medical Research

Department: Biochemistry, Neuroscience

Graduate Programs: Biological Chemistry

Biography

I was born and grew up in Wuhan, China. I obtained my B.S. degree in Biochemistry from Wuhan University. I received my Ph.D. training with Professor Steve Elledge at Baylor College of Medicine (Houston), where I studied the DNA damage checkpoints and developed a novel cloning method called UPS. I went on to do my postdoctoral fellowship with Professor Xiaodong Wang, from whom I learn the art of classical biochemistry. I joined the faculty at UT Southwestern in 2004. My research group currently focuses on understanding the molecular circuits of RNAi/microRNA and sleep regulation by combining genetics and biochemistry.   

Education

Undergraduate Wuhan University - China (1992), Biochemistry
Graduate School Baylor College of Medicine (2001), Cell Biology

Research Interests

  • Molecular Circuits of Mammalian Sleep Regulation
  • Molecular Mechanisms of RNA Interference
  • Regulatory Mechanisms of MicroRNA Biogenesis

Publications

Featured Publications Legend

Featured Publications

Sjogren Syndrome Antigen B (SSB)/La promotes global microRNA expression by binding microRNA precursors through stem-loop recognition.

C. Liang, K. Xiong, K.E. Szulwuch, Y. Zhang, Z. Wang, J. Peng, M. Fu, P. Jing, H.I. Suzuki, Q. Liu. J Biol Chem 2013 288 723-36

Autoantigen La promotes RNAi, antiviral response, and transposon silencing by facilitating multi-turnover RISC catalysis.

Y. Liu, H. Tan, H. Tian, C. Liang, S. Chen, Q. Liu. Mol. Cell 2011 44: 502-508

Structure of C3PO and mechanism of human RISC activation.

X. Ye, N. Huang, Y. Liu, Z. Paroo, C. Huerta, P. Li, S. Chen, Q. Liu*, H. Zhang* (co-corresponding authors) Nat Struct Mol Biol. 2011 18: 650-657

The functional anatomy of Drosophiila microRNA-generating enzyme

X. Ye, P. Zain, and Q. Liu J. Biol. Chem. July 2007 282 (39) 28373-28378

The miRNA pathway intrinsically controls self-renewal of Drosophila germline stem cells.

J. Park*, X. Liu*, T. Strauss, D. McKearin, and Q. Liu Curr. Biol. 2007 17 533-538

Results 1-10 of 11

Honors/Awards

  • Damon Runyon Scholar Award
    (2005)
  • Deborah and W.A. "Tex" Moncrief, Jr. Scholar in Medical Research
    (2004)