Laurentiu Pop, M.D.

Certified Principal Investigator by Academy of Clinical Research Professionals (2017)

American Board of Medical Laboratory Immunology Diplomate (2013)

Residency University of Medicine and Pharmacy, Craiova, Romania, Oncology (2000)

Graduate School University of Craiova, Romania, Medicine (1993)

Medical School

University of Craiova Medical (1993), Medicine

• Angiogenesis as a target for cancer therapy
• B and T regulatory cells
• Catabolism of immunoglobulins
• Clinical research in oncology
• Engineering monoclonal antibodies and immunoconjuates for cancer therapy
• Immunogenic effect of heavy particle radiation
• Immunomodulatory effect of radiation therapy
• Innnate immunity DNA-sensing pathways
• Mineral metabolism
• Multidrug resistance in cancer therapy
• Obesity, inflammation and cancer
• Pancreatic cancer stem cells
• Pathophysiology of glomerular filtration
• Tumor dormancy
• Type 1 and 2 diabetes
• Vaccinology

Radiation-Induced Innate Neutrophil Response in Tumor Is Mediated by the CXCLs/CXCR2 Axis

Zhang F, Mulvaney O, Salcedo E, Manna S, Zhu JZ, Wang T, Ahn C, Pop LM, Hannan R Cancers 2023 Dec 15

Phase 2 Trial of Stereotactic Ablative Radiotherapy for Patients with Primary Renal Cancer

Hannan R, McLaughlin MF, Pop LM, Pedrosa I, Kapur P, Garant A, Ahn C, Christie A, Zhu J, Wang T, Robles L, Durakoglugil D, Woldu S, Margulis V, Gahan J, Brugarolas J, Timmerman R, Cadeddu J European urology 2023 Sep 84 275-286

Systemic immune parameters after prior radiation therapy in patients receiving immune checkpoint inhibitors

Mundra V, Yang Y, von Itzstein MS, Fattah F, Gonugunta AS, Hannan R, Pop LM, Zhang Y, Wang Y, Sheffield T, Xie Y, Dowell JE, Homsi J, Rashdan S, Park J, Li QZ, Wakeland EK, Gerber DE Translational Oncology 2023 Aug 34

Phase II Trial of Sipuleucel-T and Stereotactic Ablative Body Radiation for Patients with Metastatic Castrate-Resistant Prostate Cancer

Hannan R, Dohopolski MJ, Pop LM, Mannala S, Watumull L, Mathews D, Gao A, Garant A, Arriaga YE, Bowman I, Chung JS, Wang J, Ariizumi K, Ahn C, Timmerman R, Courtney K Biomedicines 2022 Jun 10

Outcome and Immune Correlates of a Phase II Trial of High-Dose Interleukin-2 and Stereotactic Ablative Radiotherapy for Metastatic Renal Cell Carcinoma

Hannan R, Mohamad O, de Leon AD, Manna S, Pop LM, Zhang Z, Mannala S, Christie A, Christley S, Monson N, Ishihara D, Hsu EJ, Ahn C, Kapur P, Chen M, Arriaga Y, Courtney K, Cantarel B, Wakeland EK, Fu YX, Pedrosa I, Cowell L, Wang T, Margulis V, Choy H, Timmerman RD, Brugarolas J Clinical Cancer Research 2021 Dec 27 6716-6725

Transcriptomic analysis links hepatocellular carcinoma (HCC) in HZE ion irradiated mice to a human HCC subtype with favorable outcomes

Ding LH, Yu Y, Edmondson EF, Weil MM, Pop LM, McCarthy M, Ullrich RL, Story MD Scientific reports 2021 Dec 11

Renal lipid metabolism abnormalities in obesity and clear cell renal cell carcinoma

Bobulescu IA, Pop LM, Mani C, Turner K, Rivera C, Khatoon S, Kairamkonda S, Hannan R, Palle K Metabolites 2021 Sep 11

Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy (PULSAR) in Preclinical Models Enhances Single-Agent Immune Checkpoint Blockade

Moore C, Hsu CC, Chen WM, Chen BP, Han C, Story M, Aguilera T, Pop LM, Hannan R, Fu YX, Saha D, Timmerman R International Journal of Radiation Oncology Biology Physics 2021 Aug 110 1306-1316

Neoadjuvant SABR for Renal Cell Carcinoma Inferior Vena Cava Tumor Thrombus—Safety Lead-in Results of a Phase 2 Trial

Margulis V, Freifeld Y, Pop LM, Manna S, Kapur P, Pedrosa I, Christie A, Mohamad O, Mannala S, Singla N, Wait M, Bagrodia A, Woldu SL, Gahan J, Brugarolas J, Timmerman R, Hannan R International Journal of Radiation Oncology Biology Physics 2021 Jul 110 1135-1142

Renal lipid accumulation, oxidative stress and uric acid handling in a rodent model of obesity and metabolic syndrome

Rosenthal TR, Park SK, Kairamkonda S, Khatoon S, Pop LM, Bobulescu IA Journal of Investigative Medicine 2021 Apr 69 863-869

 Featured Books

Immunotherapy. In Fundamental Immunology

Paul W.E. (2003). Lippincott Williams & Wilkins

• American Association of Immunologists (2005)
• American Diabetes Association (2016)
• American Society for Microbiology (2010)
• Association of Clinical Research Professionals (2017)