Meet Dr. Vitaly Margulis

Vitaly Margulis, M.D., believes in working smarter, not harder, and he applies that philosophy to cancer care.

UT Southwestern is on the leading edge of surgical expertise, and our multidisciplinary care translates into better outcomes.”

“I know my patients want to get on with their lives, so I strive for maximum results with minimal treatment,” he says. “I’m always looking for ways to make surgery smarter or achieve the same result with, for example, four cycles of chemotherapy rather than 10.”

An Associate Professor of Urology at UT Southwestern Medical Center, Dr. Margulis uses robotics, laparoscopy, focal therapy, and open surgical techniques to treat soft-tissue tumors and kidney, prostate, bladder, testicular, penile, and adrenal cancers. His primary interest, however, is kidney cancer, and he is studying the genetic changes of the disease, what causes it to spread, and how to stop it.

Dr. Margulis considers himself a shepherd who merely guides and gives medical advice. Patients, he says, have the most important role on his team. He believes they respond better to treatment when they are part of the equation.

He also treats each patient as an individual and views his or her cancer as a separate entity.

“Personalized cancer management is what patients are looking for,” he says. “This is the future of medicine, which we try to deliver now.”

Clinical Interests/Specialties


  • Kidney cancer, masses, and tumors
  • Testicular cancer
  • Bladder cancer, masses, and tumors
  • Penile cancer
  • Urethral cancer
  • Adrenal cancer, masses, and tumors
  • Retroperitoneal sarcoma
    • Soft-tissue tumors
  • Prostate cancer
  • Genetic malignancies
    • VHL (Von-Hippel Lindau)
    • TSC (Tuberous sclerosis)

Genitourinary Surgery

  • Minimally invasive cancer surgery