Vitaly Margulis, M.D. Professor Endowed Title Paul C. Peters, M.D., Chair in Urology School Medical School Department Urology You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Upon completion of a B.S. degree in biology and biochemistry with highest honors at the University of Texas, and honors medical degree at The University of Texas Southwestern Medical School, I was accepted into a highly competitive urology residency at the University of Texas Southwestern Medical Center in Dallas. During residency training, additional research time was focused on minimally invasive techniques to manage small renal masses, evaluation of a novel approach to perform nephron sparing surgery utilizing radiofrequency ablation, and utilization of tissue micro-array technology to evaluate biomarkers as predictors of bladder cancer outcome. Upon completion of rigorous clinical training in urology, I have entered and completed urologic oncology fellowship at the MD Anderson Cancer Center, where my research focus was on understanding the molecular biology of renal cell carcinogenesis and progression as a model for developing novel diagnostic and therapeutic strategies for this disease. Specifically, our group investigated the role of TGF-beta signal transduction in human renal cell carcinoma with goals of developing targeted therapies. Current scientific endeavors include identification of novel biomarkers in renal cell carcinoma, which could potentially allow for timely diagnosis, staging, prognostication and identification of candidates for adjuvant systemic therapies. Education Medical School UT Southwestern Medical School (2001) Internship UT Southwestern Medical Center (2002), General Surgery Residency UT Southwestern Medical Center (2006), Urology Fellowship UT MD Anderson Cancer Center (2009), Urologic Oncology Research Interest Metastatic progression and resistance to targeted therapies Molecular biology involved in renal cell cancer tumorigenesis Publications Featured Publications Magnetic Resonance Imaging - guided In-bore and Magnetic Resonance Imaging-transrectal Ultrasound Fusion Targeted Prostate Biopsies: An Adjusted Comparison of Clinically Significant Prostate Cancer Detection Rate Costa D, Goldberg K, de Leon A, Lotan Y, XI Y, Aziz M, Frefeld Y, Margulis V, Raj G, Roehrborn CG, Hornberger B, Desai N, Bagrodia A, Francis F, Pedrosa I, Cadeddu J. 2019 Stereotactic radiation therapy of renal cancer inferior vena cava tumor thrombus Freifeld Y, Margulis V, Woldu S, Timmerman R, Brugarolas J, Hannan R. 2019 Detection of invasive renal cell carcinoma with targeted molecular imaging Margulis V, Hammers H, Sun X, Taneja S, Salzer J. 2019 Optimal sampling scheme in men with abnormal multiparametric MRI undergoing MRI-TRUS fusion prostate biopsy. Urologic Oncology: Seminars and Original Investigations Freifeld Y, Xi Y, Passoni N, Woldu S, Hornberger B, Goldberg K, Bagrodia A, Raj G, Margulis V, Cadeddu J, Lotan Y, Francis F, Pedrosa I, Roehrborn CG, Costa D. 2018 Safety and Efficacy of Stereotactic Ablative Radiation Therapy for Renal Cell Carcinoma Extracranial Metastases. Wang CJ, Christie A, Lin MH, Jung M, Weix D, Huelsmann L, Kuhn K, Meyer J, Desai N, Kim DWN, Pedrosa I, Margulis V, Cadeddu J, Sagalowsky A, Gahan J, Laine A, Xie XJ, Choy H, Brugarolas J, Timmerman R, Hannan R Int. J. Radiat. Oncol. Biol. Phys. 2017 May 98 1 91-100 A Multi-Institutional Comparison of Clinicopathological Characteristics and Oncologic Outcomes of Upper Tract Urothelial Carcinoma in China and the United States Singla N, Fang D, Su X, Bao Z, Cao Z, Jafri SM, Xiong G, Zhang L, Hutchinson R, Sagalowsky AI, Lotan Y, Li X, Zhou L, Raman JD, Margulis V 2017 Impact of Hospital caseVolume on Testicular Cancer Outcomes and Practice Patterns Woldu SL, Matulay JT, Clinton TN, Singla N, Krabbe LM, Hutchinson RC, Sagalowsky A, Lotan Y, Margulis V, Bagrodia A. 2017 Differences at Presentation and Treatment of Testicular Cancer in Hispanic Men: Institutional and National Hospital-based Analyses Woldu Sl, Aydin AM, Rao AV, Hutchinson RC, Singla N, Clinton TN, Krabbe LM, Passoni NM, Raj GV, Miller DS, Amatruda JF, Sagalowsky A, Lotan Y, Arriaga Y, Margulis V, Bagrodia A. 2017 Oncology: Adrenal/Renal/Upper Tract/Bladder Prognostic Value of PD-1 and PD-L1 Expression in Patients with High Grade Upper Tract Urothelial Carcinoma Krabbe LM, Heitzplatz B, Presuss S, Hutchinson RC, Woldu SL, Singla N, Boegemann M, Wood CG, Karam JA, Weizer AZ, Raman JD, Remzi M, Rioux-Leclercg N, Haitel A, Rapoport LM, Glybochko PV, Roscigno M, Bolenz C, Bensaleh K, Sagalowsky AI, Shariat SF, Lotan Y, Xylinas E, Margulis V. 2017 Androgen receptor expression is associated with adverse pathological features in ureteral but not in pelvicalyceal urothelial carcinomas of the upper urinary tract. Wirth GJ, Haitel A, Moschini M, Soria F, Klatte T, Hassler MR, Bensalah K, Briganti A, Karam JA, Lotan Y, Margulis V, Raman JD, Remzi M, Rioux-Leclercq N, Robinson BD, Rouprêt M, Wood CG, Shariat SF World J Urol 2016 Oct Results 1-10 of 24 1 2 3 Next Last Honors & Awards Merit AwardAmerican Society of Clinical Oncology (2008) National Institute of Health Clinical Research Scientist LRP AwardNIH (2007) American Urological Association Foundation Research Scholar AwardAFUD/AUA (2006) Ruth L. Kirschstein National Research Service AwardUniversity of Texas MD Anderson Cancer Center (2006) Alpha Omega AlphaUT Southwestern Medical School (2001) Professional Associations/Affiliations American Association for Cancer Research American College of Surgeons American Medical Association American Society of Clinical Oncology American Urological Association Dallas County Medical Society Endourologic Society Harris County Medical Society Society of Urologic Oncology Texas Medical Association
