David Self, Ph.D.

Professor

Endowed Title: Wesley Gilliland Professorship in Biomedical Research

Department: Psychiatry

Graduate Programs: Neuroscience

Biography

Dr. Self received his bachelor’s in Zoology from Iowa State University in 1985, and worked as a biochemist at Endocrine Sciences in Los Angeles, CA until 1987. Dr. Self entered graduate school in 1987 in the Department of Pharmacology at UC Irvine, and received a Ph.D. there in 1992. Dr. Self was a postdoctoral fellow from 1992-1995 in the Division of Molecular Psychiatry at Yale University. Dr. Self was appointed to an Assistant Professorship in the Psychiatry Department at Yale University in 1996.

In late 2000, Dr. Self joined the UT Southwestern faculty as an Associate Professor of Psychiatry in the Seay Center for Basic and Applied Research in Psychiatric Illness. Dr. Self has pioneered work on the role of neuroadaptations in addictive behavior, and has identified important neurobiological mechanisms underlying drug craving and relapse to drug seeking. In 1996, he was awarded a Presidential Early Career Award by the White House, and in 2006, the prestigious Daniel H. Efron Award by the American College of Neuropsychopharmacology, for contributions relating to this work. Dr. Self was appointed Director of the Psychiatry Neuroscience Division in 2013. His laboratory continues to implement modern molecular technology in the study of addictive behavior.

Education

Undergraduate Iowa State University (1985)
Graduate School University of California-Irvine (1992)

Research Interests

  • Behavioral Neuroscience
  • Neurobiology of Addiction
  • Neuropharmacology
  • Systems Neuroscience

Publications

Featured Publications Legend

Featured Publications

Emergence of context-associated GluR(1) and ERK phosphorylation in the nucleus accumbens core during withdrawal from cocaine self-administration.

Edwards S, Bachtell RK, Guzman D, Whisler KN, Self DW Addict Biol 2011 Jul 16 3 450-7

Striatal signal transduction and drug addiction.

Philibin SD, Hernandez A, Self DW, Bibb JA Front Neuroanat 2011 5 60

Striatal regulation of ?FosB, FosB, and cFos during cocaine self-administration and withdrawal.

Larson EB, Akkentli F, Edwards S, Graham DL, Simmons DL, Alibhai IN, Nestler EJ, Self DW J. Neurochem. 2010 Oct 115 1 112-22

Stress-related receptor targets for cocaine addiction.

Self DW Biol. Psychiatry 2010 Aug 68 3 217-8

Results 1-10 of 71

Books

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Featured Books

Honors/Awards

  • American College of Neuropsychopharmacology
    Elected to Fellow (2011)
  • Daniel H. Efron Research Award
    American College of Neuropsychopharmacology (2006)
  • Lydia Bryant Test Professorship
    Dept. of Psychiatry. UT Southwestern Medical Center (2001)
  • Presidential Early Career Award for Scientists and Engineers (PECASE)
    Awarded by the White House for "Innovative integration of molecular biology with behavioral, pharmacological and biochemical techniques in the study of drug addiction" (1996)

Professional Associations/Affiliations

  • American College of Neuropsychopharmacology
  • College on Problems of Drug Dependence
  • European Behavioural Pharmacology Society
  • Society for Neuroscience
  • Society of Biological Psychiatry