Dr. Lisa Monteggia is a Professor in the Department of Neuroscience and holds the Ginny and John Eulich Professorship at UT Southwestern Medical Center. Her lab focuses on the role of the molecular and cellular basis of neural plasticity as it pertains to neuropsychiatric disorders. Her research interest has been focused in two areas. First, she is working to elucidate the mechanisms underlying antidepressant efficacy. Second, she is studying the role of Methyl-CpG-binding protein 2 (MeCP2), the gene linked to the autism spectrum disorder, Rett syndrome, on synaptic plasticity and behavior. Her research encompasses molecular, cellular, behavioral and electrophysiological approaches using mouse models. Dr. Monteggia was an undergraduate at the University of Illinois at Urbana-Champaign, receiving a B.S. in Microbiology in 1989 and then a M.S. in Biology in 1991. Dr. Monteggia then worked for several years in a pharmaceutical company where she was promoted to the level of Scientist. Concurrently, Dr. Monteggia attended the Chicago Medical School receiving a Ph.D. in Neuroscience and working with Dr. Marina Wolf in the area of drug abuse. Dr. Monteggia then moved to Yale University to work with Dr. Eric Nestler in the area of molecular psychiatry. During her postdoctoral research, Dr. Monteggia received a postdoctoral NRSA fellowship and a young investigator award from the National Alliance for Research on Schizophrenia and Depression (NARSAD). In Fall 2002, Dr. Monteggia joined the Department of Psychiatry at UT Southwestern Medical School as an Assistant Professor. As an independent investigator, Dr. Monteggia received the 2005 Daniel X. Freedman Award from NARSAD for outstanding brain and behavioral research by young investigator. In 2011, she received the Rising Star Award from the International Mental Health Research Organization. In 2011, Dr. Monteggia was also the recipient of the Daniel H. Efron Award for outstanding basic/translational research by the American College of Neuropsychopharmacology. Dr. Monteggia is an Associate Editor of Neuropsychopharmacology and a member of the editorial boards of the Journal of Neuroscience, Journal of Biological Chemistry and Biological Psychiatry. She has served on grant review panels for the National Institutes of Health, the National Science Foundation, as well as numerous scientific foundations. She recently was Editor to The Autisms: Molecules to Model Systems published by Oxford University Press.
- Univ of Illinois @ Urbana-Cham (1989), Microbiology
- Graduate School
- Univ of Illinois @ Urbana-Cham (1991), Biology
- Development of Animal Models for Psychiatric Diseases
- Elucidating the Role of MeCP2 in Mediating Autistic-like Behavior (autism)
- Mechanisms Underlying Rapid Antidepressant Action
- Role of Growth Factors in Depression
- Role of Transcriptional Repression in Neurons
- Circadian rhythms: Depression brought to light.
- Monteggia LM, Kavalali ET Nature 2012 Nov 491 7425 537-8
- A mouse model for MeCP2 duplication syndrome: MeCP2 overexpression impairs learning and memory and synaptic transmission.
- Na ES, Nelson ED, Adachi M, Autry AE, Mahgoub MA, Kavalali ET, Monteggia LM J. Neurosci. 2012 Feb 32 9 3109-17
- NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses.
- Autry AE, Adachi M, Nosyreva E, Na ES, Los MF, Cheng PF, Kavalali ET, Monteggia LM Nature 2011 Jul 475 7354 91-5
- Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress
- Berton, O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW, Nestler EJ Science 2006 311 864-868
- MeCP2-dependent transcriptional repression regulates excitatory neurotransmission
- Nelson E, Kavalali ET, Monteggia LM Current Biology 2006 16 710-716
- Loss of Histone Deacetylase 2 Improves Working Memory and Accelerates Extinction Learning
- Morris MJ, Mahgoub MA, Na ES, Pranav H, Monteggia LM J Neurosci 2013 In press
- An essential role for histone deacetylase 4 in synaptic plasticity and memory formation.
- Kim MS, Akhtar MW, Adachi M, Mahgoub M, Bassel-Duby R, Kavalali ET, Olson EN, Monteggia LM J. Neurosci. 2012 Aug 32 32 10879-86
- Brain-derived neurotrophic factor and neuropsychiatric disorders.
- Autry AE, Monteggia LM Pharmacol. Rev. 2012 Apr 64 2 238-58
- In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival.
- Akhtar MW, Kim MS, Adachi M, Morris MJ, Qi X, Richardson JA, Bassel-Duby R, Olson EN, Kavalali ET, Monteggia LM PLoS ONE 2012 7 4 e34863
- Activity-dependent suppression of miniatureneurotransmission through the regulation of DNA methylation
- Nelson ED, Kavalali ET, Monteggia LM J Neurosci 2008 28(2): 395-406
The Autisms: Molecules to Model Systems
(Ed.) (2012). Oxford University Press
Honors & Awards
- Daniel H. Efron Award
Outstanding Basic Research Contributions, American College of Neuropsychopharmacology (2011)
- Rising Star Award
International Mental Health Research Organization (2011)
- Ginny and John Eulich Professorship in Autism Spectrum Disorders
- Daniel X. Freedman Award
Award for Outstanding Basic Research Achievement, (NARSAD) (2005)
- 2003, 2001 Young Investigator Awards
National Alliance for Research on Schizophrenia and Depression (NARSAD) (2003)
- Independent Investigator Award
National Alliance for Autism Research (NAAR) (2001)
- American College of Neuropsychopharmacology
- Serotonin Club
- Society for Neuroscience