Biography

The focus of the Reimold lab's research program is to understand how transcription factors control the expression of genes involved in inflammation. Insights into how these proteins turn genes on and off may lead to new treatments for rheumatic diseases. They have studied transcription factors binding to DNA at cyclic AMP response elements, a sequence of widespread importance in the regulation of proinflammatory genes. To determine the precise functions of these transcription factors, mice with targeted disruptions of the genes under study were genereated and have revealed defects in embryonic growth and development, as well as impaired activation of inflammatory pathways. Recently they have identified a block in the pathway of B lymphocyte terminal differentiation in one of our knockout mouse models. Further work will help to elucidate how the interaction of transcription factors with each other and with their target genes regulates the production of immunoglobulin-secreting plasma cells.

Education

Medical School Columbia University College of Physicians and Surgeons (1984)
Fellowship Harvard Medical School (1991), Rheumatology
Fellowship Harvard Medical School (1993), Immunology

Specialty Areas

Clinical Interest

  • Ankylosing Spondylitis
  • Behcet's Syndrome
  • Calcinosis, Raynaud Phenomenon, Esophageal Dysmotility, Schlerodactyly & Telangiectasia (CREST) Syndrome
  • Calcium Pyrophosphate Dihydrate Deposition (CPPD) Disease
  • Circumscribed Scleroderma
  • Dermatomyositis
  • Elevated Rheumatoid Factor
  • Giant Cell Arteritis
  • Gout
  • Inflammatory Arthritis
  • Joint Pain & Swelling
  • Lupus
  • Mixed Connective Tissue Disease
  • Myositis
  • Polymyalgia Rheumatica
  • Polymyositis - Rheumatology Conditions
  • Pseudogout
  • Psoriatic, Reactive & Temporal Arthritis
  • Relapsing Polychondritis
  • Rheumatoid Arthritis
  • Systemic Lupus Erythematosus (SLE)
  • Systemic Sclerosis
  • Undifferentiated Spondyloarthritis
  • Vasculitis
  • Wegener's Granulomatosis

Research Interest

  • Mechanisms of B cell differentiation
  • Transcriptional regulation of lymphocyte function

Publications

Featured Publications LegendFeatured Publications

New indications for treatment of chronic inflammation by TNFa blockade
Reimold, A.M. American Journal of Medical Science 2003 325 75-92
Plasma cell differentiation requires the trasncription factor XBP-1
Reimold A.M., N.N. Iwakoshi, J. Manis, P. Vallabhajosyula, E. Szomolanyi-Tsuda, E.M. Gravallese, D. Friend, M.J. Grusby, F. Alt, L.H. Glimcher Nature 2001 412 300-307
An essential role in liver development for transcription factor XBP-1
Reimold A.M., A. Etkin, I Clauss, A. Perkins, D.S. Friend, J. Zhang, H.F. Horton, A. Scott, S. Orkin, M.C. Byrne, M.J. Grusby, L.H. Glimcher Genes and Development 2000 14 152-157

Honors & Awards

  • Lyndon Baines Johnson Research Award
    American Heart Association (2002)
  • Arthritis Investigator Award
    American College of Rheumatology (1997)

Professional Associations/Affiliations

  • American Association of Immunologists
  • American College of Rheumatology
  • Arthritis Foundation