Wen-Hong Li, Ph.D.

• Cell biology of diabetes and insulin release in islet beta cells
• Functional analysis of microRNAs
• Probe engineering and chemical biology

 Featured Publications

Temporal and Spatial Regulation of MicroRNA Activity with Photoactivatable Cantimirs.

Zheng G, Cochella L, Liu J, Hobert O, Li WH ACS Chem. Biol. 2011 Dec 6 12 1332-8

Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR).

Li D, Chen S, Bellomo EA, Tarasov AI, Kaut C, Rutter GA, Li WH Proceedings of the National Academy of Sciences of the United States of America 2011 Dec

Inhibiting miRNA in Caenorhabditis elegans using a potent and selective antisense reagent.

Zheng G, Ambros V, Li WH Silence 2010 1 1 9

Imaging dynamic cell-cell junctional coupling in vivo using Trojan-LAMP

Yan-Ming Guo, Shiuhwei Chen, Premnath Shetty, Genhua Zheng, Rueyling Lin, Wen-hong Li Nature Methods 2008 5 835-841

LAMP, A New Imaging Assay of Gap Junctional Communication Unveils That Ca2+ Influx Inhibits Cell Coupling

Kenneth Dakin, YuRui Zhao & Wen-hong Li Nature Methods 2005 2 55-62 (News & Views, 12-14)

Photoactivatable and Water Soluble FRET Dyes with High Uncaging Cross Section

Genghua Zheng, Yan-Ming Guo & Wen-hong Li J. Am. Chem. Soc. 2007 129 10616-10617

Cell Membrane Permeable Esters of D-myo-Inositol 1,4,5-Trisphosphate

Kenneth Dakin & Wen-hong Li Cell Calcium 2007 42 291-301

Infrared LAMP, Two-Photon Uncaging and Imaging of Gap Junctional Communication in Three Dimensions

Kenneth Dakin & Wen-hong Li Nature Methods 2006 3 959

Local Ca2+ Rise Near Store Operated Ca2+ Channels Inhibits Cell Coupling During Capacitative Ca2+ Influx

Kenneth Dakin & Wen-hong Li Cell Commun. Adhes. 2006 13 29-39

A New Class of Macrocyclic Lanthanide Complexes for Cell Labeling and Magnetic Resonance Imaging Applications

Quan Zheng, Houquan Dai, Matthew E. Merritt, Craig Malloy, CaiYuan Pan & Wen-hong Li J . Am. Chem. Soc. 2005 127 16178-16188

• Junior Investigator Award
  American Cancer Society (2002)
• Career Development Award
  American Diabetes Association (2001)
• Martin D. Karmen Prize
  In recognition of the excellence of Ph.D. thesis, UCSD (1997)
• Jane Hart Memorial Award
  Department of Chemistry and Biochemistry, University of California, San Diego (1994)

• The American Chemical Society
• The American Diabetes Association (2006)
• The American Society for Cell Biology