Paul E. Pepe, M.D., M.P.H., a Professor with Tenure in Internal Medicine, Surgery, Pediatrics, Public Health & Emergency Medicine (EM) at UT Southwestern, is the City of Dallas Director of Medical Emergency Services for Public Safety, Public Health & Homeland Security. He is also is the jurisdictional Medical Director for the regional EMS system (about a quarter million annual 9-1-1 incidents, involving about 3,000 paramedics/first responders in Dallas and 18 surrounding cities) and is the Medical Director for the Dallas County EMS system and for special operations for the DFW Airport as well as the Dallas Police Dept. and the Dallas Metropolitan Medical Response System for counter-terrorism and disaster mitigation.

An extremely distinguished academician, he headed the clinical, administrative, academic and research programs in EM at UT Southwestern between 2000 and 2014 and was EM Chair at the Medical College of Pennsylvania Pittsburgh campus in the 1990s.

With over 400 published scientific papers/abstracts, including many landmark publications, Dr. Pepe has served simultaneously as a high-level municipal or state employee for over three decades. Renown for a grass-roots, street-wise style in planning, implementing and overseeing a systems approach to saving lives, both operationally and through clinical trials, his programs have resulted in some of the highest cardiac arrest and trauma survival rates worldwide. In addition to the Chain of Survival publication, he is known for his original measurements of physiological mechanisms (eg, Auto-PEEP), intrepid clinical concepts (eg, deferred rescue breaths in CPR), and ground-breaking clinical trials (eg, deferred IV fluids for trauma). Published years ago by Dr. Pepe & colleagues, these studies are now part of mainstream medical practice and research.

Many of his numerous studies, injury prevention programs and media interactions have consistently affected public policy and legislation. Helping to set national priorities for cardiac and trauma resuscitation research, the NIH formally designated his EM program at UT as a federally-funded resuscitation research center in 2004, a very successful program that continues today.

He served as an assistant to the medical directors of the Seattle Fire Department EMS (1977-82), as Director for the City of Houston EMS System (1982-96) and as Commonwealth Emergency Medical Director for Pennsylvania under Governor Tom Ridge. In addition, Dr. Pepe has served for years as emergency medicine-trauma consultant to various entities such as the White House Medical Unit, U.S. Secret Service (USSS), FBI, NIH, network news organizations, and even the National Basketball Association Trainers. He coordinates the so-called Eagles consortium, a cohesive and highly-influential de facto coalition of the jurisdictional 9-1-1 (EMS) system medical directors for the nation’s 30-40 largest cities and pivotal federal agencies (eg, FBI, USSS, ATF, DHS, HHS, White House Medical Unit).

An omnipresent global lecturer, he has won numerous health policy, community service, scientific, educational and professional society awards, here and abroad, including distinguished alumnus awards and a formal citation for courage and life-time public service in the U.S. Congressional Record. He was recently nominated ’Texan of the Year’ and was elected to Mastership in the American College of Physicians (MACP) for numerous lifetime achievements in Internal Medicine and received similar recognition in 2014 from the Society for Academic Emergency Medicine for lifetime achievements and excellence in research.

Often featured on network news and prime-time broadcasts (e.g., Rescue 9-1-1 pilot, ABC News Nightline special, ’In the ER’, TLC’s award-winning, ’The Strongest Link’, and Larry King Live), he has been called a ’Mentor to Millions’ and an ’Advocate for the Injured’. When recently receiving an award in Washington, DC for lifetime professional achievements presented by then U.S. Surgeon General, Richard Carmona, on behalf of the American College of Emergency Physicians (ACEP), Dr. Pepe was cited as the most accomplished emergency medical services physician of our generation.


Medical School University of California, San Francisco (1976)
Residency University of WA, School of Medicine (1979), Internal Medicine
Fellowship University of WA Medical Center (1982), Pulmonary Diseases & Critical Care Medicine
Graduate School University of Texas School of Public Health (1995)

Specialty Areas

Clinical Interest

  • Emergency Medicine
  • Resuscitation

Research Interest

  • Clinical Trials of Interventions for Cardiac Arrest Resuscitation
  • Clinical Trials of Interventions for Trauma Resuscitation
  • EMS System Organization
  • Event Medicine and Mass Gathering Medicine
  • Interventions for Coronary Artery Syndromes
  • Optimization of Ventilatory Techniques in Severe Hemorrhage and Cardiac Arrest
  • Use of Hormones in Resuscitation


Featured Publications LegendFeatured Publications

Prehospital endotracheal intubation: elemental or detrimental?
Pepe PE, Roppolo LP, Fowler RL Crit Care 2015


Featured Books Legend Featured Books

Honors & Awards

  • Excellence in Research Award from the Society for Academic Emergency Medicine
    Awarded for lifetime achievements in research and advancing the mission of the specialty of Emergency Medicine (2014)
  • National Finalist, Emergency Medicine Foundation Emergency Department Director of the Year Award
    Recognized for dramatic improvements in both emergency department throughput and patient satisfaction as well as cost-sparing, life-sparing initiatives in the prehospital setting (2010)
  • Elected to Mastership (MACP) by the American College of Physicians (ACP)
    Honored for life-time achievements and scientific and professional contributions in the field of Internal Medicine (2008)
  • Received the National Emergency Medical Services Award from the American College of Emergency Physicians (ACEP)
    Honored for life-time achievements and cited as the most accomplished Emergency Medical Services physicians of our generation (2005)
  • Recognized in the U.S. Congressional Record
    Honored for heroism and life-time achievements in 9-1-1 emergency services, trauma care and disaster management (2005)
  • Received Millenium-2000 Award from the Australian and New Zealand Intensive Care Society (ANZICS)
    Awarded for life-time achievement and scientific contributions to the field of Critical Care Medicine worldwide (2000)
  • Appointed Emergency Medicine and Trauma Consultant to the White House Medical Unit (WHMU)
    Since 1994, assigned (and continues) to train and advise the White House physicians, nurses, physician assistants and other medical personnel, including the Physician to the President, in the latest EM and Trauma care advances and resuscitation techniques (1994)

Professional Associations/Affiliations

  • American Association for the Surgery of Trauma (AAST), Consulting Scientist (2001)
  • American College of Critical Care Medicine,.Fellow (FCCM) (1990)
  • American College of Emergency Physicians, Fellow (FACEP) (1986)
  • American College of Physicians, Master (MACP) (1984)
  • National Association of EMS Physicians (Co-Founder) (1984)