As an undergraduate. Dr. Kavalali studied Electrical Engineering at Bogazici University in Istanbul, Turkey. In 1995, he completed his PhD in Rutgers University, where he worked with Dr. Mark Plummer. He joined the then-Center for Basic Neuroscience in September 1999, following completion of his postdoctoral studies with Dr. Richard W. Tsien in Stanford University at the Department of Molecular and Cellular Physiology.
Dr. Kavalali studies mechanisms of neurotransmission and synaptic signaling in the central nervous system. His group focuses on the molecular basis and functional consequences of heterogeneity among synaptic vesicle recycling pathways present within individual synapses. In particular, his work has uncovered the role and underlying mechanisms of spontaneous neurotransmitter release that holds it apart mechanistically and functionally from evoked neurotransmission.
- Bogazici University (1990), Engineering
- Graduate School
- Rutgers the State University (1995), Biomedical Engineering
- Neurotransmitter Release
- Synaptic Plasticity
- Synaptic Transmission
- Synaptic vesicle pool specific modification of neurotransmitter release by intravesicular free radical generation.
- Afuwape OA, Wasser CR, Schikorski T, Kavalali ET J. Physiol. (Lond.) 2016 Oct
- Spontaneous neurotransmission signals through store-driven Ca(2+) transients to maintain synaptic homeostasis.
- Reese AL, Kavalali ET Elife 2015 Jul 4
- The mechanisms and functions of spontaneous neurotransmitter release
- Kavalali ET Nature Reviews Neuroscience 2015 16 5 -16
- Fast retrieval and autonomous regulation of single spontaneously recycling synaptic vesicles.
- Leitz J, Kavalali ET eLife 2014 3/eLife.03658 Nov 21
- Reelin Mobilizes a VAMP7-Dependent Synaptic Vesicle Pool and Selectively Augments Spontaneous Neurotransmission.
- Bal M, Leitz J, Reese AL, Ramirez DM, Durakoglugil M, Herz J, Monteggia LM, Kavalali ET Neuron 2013 Nov 80 4 934-46
- Acute suppression of spontaneous neurotransmission drives synaptic potentiation.
- Nosyreva E, Szabla K, Autry AE, Ryazanov AG, Monteggia LM, Kavalali ET J. Neurosci. 2013 Apr 33 16 6990-7002
- VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.
- Raingo J, Khvotchev M, Liu P, Darios F, Li YC, Ramirez DM, Adachi M, Lemieux P, Toth K, Davletov B, Kavalali ET Nature neuroscience 2012 Mar
- Vti1a identifies a vesicle pool that preferentially recycles at rest and maintains spontaneous neurotransmission.
- Ramirez DM, Khvotchev M, Trauterman B, Kavalali ET Neuron 2012 Jan 73 1 121-34
- NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses.
- Autry AE, Adachi M, Nosyreva E, Na ES, Los MF, Cheng PF, Kavalali ET, Monteggia LM Nature 2011 Jul 475 7354 91-5
- Acute dynamin inhibition dissects synaptic vesicle recycling pathways that drive spontaneous and evoked neurotransmission.
- Chung C, Barylko B, Leitz J, Liu X, Kavalali ET J. Neurosci. 2010 Jan 30 4 1363-76
Honors & Awards
- NARSAD Distinguished Investigator Award
- American Heart Association Established Investigator Award
- Effie Marie Cain Scholar in Medical Research
- American Heart Association Postdoctoral Fellowship