As an undergraduate Dr. Kavalali studied Electrical Engineering at Bogazici University in Istanbul, Turkey. In 1995, he received his Ph.D. degree from Rutgers University, where he worked with Dr. Mark Plummer. In 1999, he completed his postdoctoral studies with Dr. Richard W. Tsien in Stanford University at the Department of Molecular and Cellular Physiology. The same year, Dr. Kavalali joined the then-Center for Basic Neuroscience at UT Southwestern directed by Dr. Thomas C. Südhof as a faculty member.
Dr. Kavalali studies mechanisms of neurotransmission and synaptic signaling in the central nervous system. His group focuses on the molecular basis and functional consequences of heterogeneity among synaptic vesicle recycling pathways present within individual synapses. In particular, his work has uncovered the role and underlying mechanisms of spontaneous neurotransmitter release that holds it apart mechanistically and functionally from evoked neurotransmission.
- Bogazici University (1990), Engineering
- Graduate School
- Rutgers the State University (1995), Biomedical Engineering
- Mechanisms of Rapid Antidepressant Action
- Neurotransmitter Release
- Synaptic Transmission and Plasticity
- Synaptic vesicle pool specific modification of neurotransmitter release by intravesicular free radical generation.
- Afuwape OA, Wasser CR, Schikorski T, Kavalali ET J. Physiol. (Lond.) 2016 Oct
- Spontaneous neurotransmission signals through store-driven Ca(2+) transients to maintain synaptic homeostasis.
- Reese AL, Kavalali ET Elife 2015 Jul 4
- The mechanisms and functions of spontaneous neurotransmitter release
- Kavalali ET Nature Reviews Neuroscience 2015 16 5 -16
- How does ketamine elicit a rapid antidepressant response?
- Kavalali ET, Monteggia LM Curr Opin Pharmacol 2014 Nov 20C 35-39
- Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses.
- Gideons ES, Kavalali ET, Monteggia LM Proc. Natl. Acad. Sci. U.S.A. 2014 Jun 111 23 8649-54
- Fast retrieval and autonomous regulation of single spontaneously recycling synaptic vesicles.
- Leitz J, Kavalali ET eLife 2014 3/eLife.03658 Nov 21
- Reelin Mobilizes a VAMP7-Dependent Synaptic Vesicle Pool and Selectively Augments Spontaneous Neurotransmission.
- Bal M, Leitz J, Reese AL, Ramirez DM, Durakoglugil M, Herz J, Monteggia LM, Kavalali ET Neuron 2013 Nov 80 4 934-46
- Acute suppression of spontaneous neurotransmission drives synaptic potentiation.
- Nosyreva E, Szabla K, Autry AE, Ryazanov AG, Monteggia LM, Kavalali ET J. Neurosci. 2013 Apr 33 16 6990-7002
- Synaptic mechanisms underlying rapid antidepressant action of ketamine.
- Kavalali ET, Monteggia LM Am J Psychiatry 2012 Nov 169 11 1150-6
- VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.
- Raingo J, Khvotchev M, Liu P, Darios F, Li YC, Ramirez DM, Adachi M, Lemieux P, Toth K, Davletov B, Kavalali ET Nature neuroscience 2012 Mar
Honors & Awards
- NARSAD Distinguished Investigator Award
- American Heart Association Established Investigator Award
- Effie Marie Cain Scholar in Medical Research
- American Heart Association Postdoctoral Fellowship