Scott Smith, Ph.D. Associate Dean for Research, School of Health Professions | Professor & Chair Professor & Chair Endowed Title Distinguished Teaching Professor; Jere H. Mitchell, M.D. Distinguished Professorship in Clinical Research School School of Health Professions Department Applied Clinical Research | Internal Medicine | Office of the Dean - School of Health Professions Graduate Programs Biomedical Engineering Biography Dr. Smith earned his bachelor’s degree in biology/chemistry from Southwestern University in Georgetown, Texas and his master’s and doctoral degrees in biomedical science from the University of North Texas Health Science Center at Fort Worth. He completed a postdoctoral fellowship in Internal Medicine/Cardiology at UT Southwestern in 2002 and joined the faculty shortly thereafter. He is an active member of the American Heart Association, American Physiological Society and American College of Sports Medicine. He has served as the Director of the David M Crowley Research and Rehabilitation Laboratory within the School of Health Professions. In addition, he is a former member of the University of Texas System Faculty Advisory Council in which he served on the Executive Sub-Committee on Health Affairs. Dr. Smith's laboratory has been studying autonomic regulation of the cardiovascular system during exercise in both humans and animals for over 15 years. Currently, the lab's research focuses on determining the mechanisms underlying alterations in circulatory control after the development of hypertension. More specifically, the lab is actively investigating the central and peripheral mechanisms mediating the abnormal alterations in sympathetic nerve activity, blood pressure and skeletal muscle blood flow with the pathogenesis of disease. Recently, the lab has been focusing on determining the mechanisms by which exercise training improves cardiovascular function during physical activity in hypertension with the goals of identifying: i) novel treatments for the abnormal response to exercise in the disease and ii) new treatment therapies for the disease. Education Undergraduate Southwestern University (1992), Biology Graduate School Uni of North Tx Health Science (1996), Biomedical Sciences Graduate School Uni of North Tx Health Science (1999), Physiology Research Interest Autonomic Reflex Dysfunction in Heart Failure Autonomic Reflex Dysfunction in Hypertension Neural Cardiovascular Control during Exercise Sympathetic Dysfunction in Diabetes Publications Featured Publications Aldosterone and salt loading independently exacerbate the exercise pressor reflex in rats M Mizuno, RM Downey, JH Mitchell, SA Smith and W Vongpatanasin Hypertension 2015 66 627-633 Dynamic exercise training prevents exercise pressor reflex overactivity in spontaneously hypertensive rats M Mizuno, GA Iwamoto, W Vongpatanasin, JH Mitchell and SA Smith American Journal of Physiology 2015 309 H762-H770 Enalapril attenuates the exaggerated sympathetic response to physical stress in prenatally programmed hypertensive rats M Mizuno, G Lozano, K Siddique, M Baum and SA Smith Hypertension 2014 63 324-329 Exercise training improves functional sympatholysis in spontaneously hypertensive rats through a nitric oxide dependent mechanism M Mizuno, GA Iwamoto, W Vongpatanasin, JH Mitchell and SA Smith American Journal of Physiology 2014 307 H242-H251 Prenatal programming of hypertension induces sympathetic overactivity in response to physical stress M Mizuno, K Siddique, M Baum and SA Smith Hypertension 2013 61 180-186 Neuronal nitric oxide synthase protein expression is reduced within the brainstem neurons excited by skeletal muscle reflexes in spontaneously hypertensive rats MN Murphy, M Mizuno, RM Downey, JJ Squiers, KE Squiers and SA Smith American Journal of Physiology 2013 304 H1547-H1557 A role for nitric oxide within the nucleus tractus solitarius in the development of muscle mechanoreflex dysfunction in hypertension AK Leal, MN Murphy, GA Iwamoto, JH Mitchell and SA Smith Experimental Physiology 2012 97 1292-1304 Skeletal muscle reflex-mediated changes in sympathetic nerve activity are abnormal in spontaneously hypertensive rats M Mizuno, MN Murphy, JH Mitchell and SA Smith American Journal of Physiology 2011 300 The capsaicin sensitive afferent neuron in skeletal muscle is abnormal in heart failure SA Smith, MA Williams, JH Mitchell, PPA Mammen, MG Garry Circulation 2005 111 2056-2065 The role of the exercise pressor reflex in rats with dilated cardiomyopathy SA Smith, PPA Mammen, JH Mitchell, MG Garry Circulation 2003 108 1126-1132 Results 1-10 of 10 1 Books Featured Books Neural mechanisms influencing baroreflex resetting during exercise.. In Recent Research Developments in Physiology PJ Fadel, SA Smith and KM Gallagher (2004). Research Signpost Neural mechanisms of cardiovascular control during exercise in health and disease. In Recent Advances in Cardiovascular Research: From Sleep to Exercise SA Smith, AK Leal, CN Young and PJ Fadel (2010). Transworld Research Network Honors & Awards Outstanding Educator Award for Excellence in EducationSouthwestern School of Health Professions (2015) Minority Health Research and Education GrantTexas Higher Education Coordinating Board (2014) Basic Research Grant (R01)National Institutes of Health (2013) Basic Research Grant (R01)National Institutes of Health (2008) Scientist Development GrantAmerican Heart Association - National (2007) Beginning Grant-in-AidAmerican Heart Association - Texas Affiliate (2005) New Investigator Award for Excellence in ResearchSouthwestern School of Health Professions (2004) Outstanding Research AwardFederation of American Societies for Experimental Biology (2004) Young Investigator AwardAmerican Physiological Society Central Nervous System Section (2002) Graduate Faculty Award for Outstanding GraduateGraduate School of Biomedical Sciences, University of North Texas Health Science Center (1999) Professional Associations/Affiliations American College of Sports Medicine American Heart Association American Physiological Society
