The amino-terminal region of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is required for its DNA double-strand break-mediated activation.
Davis AJ, Lee KJ, Chen DJ J. Biol. Chem. 2013 Jan
Persistently bound Ku at DNA ends attenuates DNA end resection and homologous recombination.
Shao Z, Davis AJ, Fattah KR, So S, Sun J, Lee KJ, Harrison L, Yang J, Chen DJ DNA Repair (Amst.) 2012 Mar 11 3 310-6
Dynamics of the PI3K-like protein kinase members ATM and DNA-PKcs at DNA double strand breaks.
Davis AJ, So S, Chen DJ Cell Cycle 2010 Jul 9 13 2529-36
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.
So S, Davis AJ, Chen DJ J. Cell Biol. 2009 Dec 187 7 977-90
Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit.
Davis AJ, Yan Z, Martinez B, Mumby MC J. Biol. Chem. 2008 Jun 283 23 16104-14
A role for protein phosphatase 4 in regulating non-homologous end-joining.
Davis AJ, Chen DJ Cell Cycle 2012 Oct 11 19 3534-5
Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex.
Sun J, Lee KJ, Davis AJ, Chen DJ J. Biol. Chem. 2012 Feb 287 7 4936-45
Involvement of the nuclear proteasome activator PA28? in the cellular response to DNA double-strand breaks.
Levy-Barda A, Lerenthal Y, Davis AJ, Chung YM, Essers J, Shao Z, van Vliet N, Chen DJ, Hu MC, Kanaar R, Ziv Y, Shiloh Y Cell Cycle 2011 Dec 10 24 4300-10
B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation.
Jayadeva G, Kurimchak A, Garriga J, Sotillo E, Davis AJ, Haines DS, Mumby M, Graña X J. Biol. Chem. 2010 Sep 285 39 29863-73
A role for ATM kinase activity and Mre11 in microhomology-mediated end-joining.
Davis AJ, Chen DJ Cell Cycle 2010 Aug 9 16 3147-8