My laboratory studies the molecular mechanisms of intracellular signal transduction pathways using a combination of structural and biochemical approaches.  Our research program currently focuses on two major areas: (1) the spindle checkpoint and (2) the Hippo tumor suppressor pathway.  


Peking University - China (1990), Chemistry
Graduate School
Tufts University (1997), Biochemistry

Research Interest

  • Cell cycle checkpoints and cancer
  • Organ size control and cancer
  • Structural biology


Featured Publications LegendFeatured Publications

Mitosis: short-circuiting spindle checkpoint signaling.
Luo X, Yu H Curr. Biol. 2012 Feb 22 4 R128-30
Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition.
Kim S, Sun H, Ball HL, Wassmann K, Luo X, Yu H Proc. Natl. Acad. Sci. U.S.A. 2010 Nov 107 46 19772-7
Snapshots of a hybrid transcription factor in the Hippo pathway.
Luo X Protein Cell 2010 Sep 1 9 811-9
Structural and functional analysis of the YAP-binding domain of human TEAD2.
Tian W, Yu J, Tomchick DR, Pan D, Luo X Proc. Natl. Acad. Sci. U.S.A. 2010 Apr 107 16 7293-8

Honors & Awards

  • CPRIT Individual Investigator Research Awards
  • National Cancer Institute Howard Temin Award
  • American Cancer Society ACS-IRG award
  • National Institutes of Health (NIH) Postdoctoral Fellowship
  • Giovanni Armenise-Harvard Foundation Postdoctoral Fellow
    Harvard Medical School (1997)

Professional Associations/Affiliations

  • Chinese Biological Investigators Society (2005-2014)