Xuelian Luo, Ph.D.

Associate Professor

Department: Pharmacology

Graduate Programs: Molecular Biophysics

Biography

My laboratory studies the molecular mechanisms of intracellular signal transduction pathways using a combination of structural and biochemical approaches.  Our research program currently focuses on two major areas: (1) the spindle checkpoint and (2) the Hippo tumor suppressor pathway.  

Education

Undergraduate Peking University - China (1990), Chemistry
Graduate School Tufts University (1997), Biochemistry

Research Interests

  • Cell cycle checkpoints and cancer
  • Organ size control and cancer
  • Structural biology

Publications

Featured Publications Legend

Featured Publications

Mitosis: short-circuiting spindle checkpoint signaling.

Luo X, Yu H Curr. Biol. 2012 Feb 22 4 R128-30

Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition.

Kim S, Sun H, Ball HL, Wassmann K, Luo X, Yu H Proc. Natl. Acad. Sci. U.S.A. 2010 Nov 107 46 19772-7

Snapshots of a hybrid transcription factor in the Hippo pathway.

Luo X Protein Cell 2010 Sep 1 9 811-9

Structural and functional analysis of the YAP-binding domain of human TEAD2.

Tian W, Yu J, Tomchick DR, Pan D, Luo X Proc. Natl. Acad. Sci. U.S.A. 2010 Apr 107 16 7293-8

Results 1-10 of 15

Honors/Awards

  • CPRIT Individual Investigator Research Awards
    (2013)
  • National Cancer Institute Howard Temin Award
    (2003-2008)
  • American Cancer Society ACS-IRG award
    (2002)
  • National Institutes of Health (NIH) Postdoctoral Fellowship
    (1998-2001)
  • Giovanni Armenise-Harvard Foundation Postdoctoral Fellow
    Harvard Medical School (1997)

Professional Associations/Affiliations

  • Chinese Biological Investigators Society (2005-2014)