University of North Carolina A (1991), Chemistry
Graduate School
Scripps Research Institute (th (1998), Macromolecular and Cellular St

Research Interest

  • Cancer
  • Cellular sensors of environmental and metabolic cues
  • Regulation of mammalian iron homeostasis
  • Regulation of mammalian oxygen homeostasis


Featured Publications LegendFeatured Publications

Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules.
Guo Y, Partch CL, Key J, Card PB, Pashkov V, Patel A, Bruick RK, Wurdak H, Gardner KH ACS Chem. Biol. 2013 Mar 8 3 626-35
Development of inhibitors of the PAS-B domain of the HIF-2a transcription factor.
Rogers JL, Bayeh L, Scheuermann TH, Longgood J, Key J, Naidoo J, Melito L, Shokri C, Frantz DE, Bruick RK, Gardner KH, MacMillan JB, Tambar UK J. Med. Chem. 2013 Feb 56 4 1739-47
Protein degradation and iron homeostasis.
Thompson JW, Bruick RK Biochim. Biophys. Acta 2012 Sep 1823 9 1484-90

Honors & Awards

  • Edith & Peter O’Donnell Award in Medicine
    Texas Academy of Medicine, Engineering and Science (2014)
  • Young Investigator Award
    American Cancer Society (2004)
  • Distinguished Young Researcher Award
    President’s Research Council (2003)
  • Career Award in the Biomedical Sciences
    Burroughs Wellcome Fund (2002)
  • Michael L. Rosenberg Scholar in Medical Research