Kathlynn Brown, Ph.D.

Assistant Professor

Department: Internal Medicine, Simmons Comprehensive Cancer Center

Graduate Programs: Cancer Biology, Cell Regulation

Biography

Kathlynn Brown is an Assistant Professor of Internal Medicine and a member of the Simmons Cancer Center at the University of Texas Southwestern Medical Center. Dr. Brown obtained her PhD in organic chemistry at the University of Texas at Austin during which time she received fellowships from the Mahler Memorial Foundation and the Organic Division of the American Chemical Society. She continued her training at the University of California at San Francisco, where she was a Damon Runyon Walter Winchell Postdoctoral Fellow. She moved to UT Southwestern in 1998 to join the Center for Biomedical Inventions. In 2005 she became tenure-track faculty in the Department of Internal Medicine and the Harold C Simmons Comprehensive Cancer Center.

 In her independent career, she has utilized her multidisciplinary expertise in organic chemistry, peptide chemistry, biochemistry, and molecular biology to address challenges in biomedical research.  Her laboratory was among the first laboratory was among the first to adopt cell-based biopanning of phage-displayed peptide libraries. Using this approach, she has developed a suite of high affinity peptides that target a variety of different cell types. Her research team is currently focusing on the development of peptides that target non-small cell lung cancer for use as delivery vehicles for drugs, nanoparticles, and toxins. Additionally, the peptides are being utilized as molecular imaging agents for diagnosis and classification of lung tumors.

Education

Undergraduate Trinity University (1987), Chemistry
Graduate School University of Texas at Austin (1994), Chemistry

Research Interests

  • cancer biomarker identification
  • cell-specific targeting
  • drug delivery
  • integrin biology
  • lung cancer
  • receptor-ligand interactions

Publications

Featured Publications Legend

Featured Publications

From phage display to nanoparticle delivery: functionalizing liposomes with multivalent peptides improves targeting to a cancer biomarker.

Gray BP, Li S, Brown KC Bioconjug. Chem. 2013 Jan 24 1 85-96

Synthesis and biological evaluation of a peptide-paclitaxel conjugate which targets the integrin avß6.

Li S, Gray BP, McGuire MJ, Brown KC Bioorg. Med. Chem. 2011 Sep 19 18 5480-9

MRI-visible micellar nanomedicine for targeted drug delivery to lung cancer cells.

Guthi JS, Yang SG, Huang G, Li S, Khemtong C, Kessinger CW, Peyton M, Minna JD, Brown KC, Gao J Mol. Pharm. 2010 Feb 7 1 32-40

Peptidic tumor targeting agents: the road from phage display peptide selections to clinical applications.

Brown KC Curr. Pharm. Des. 2010 16 9 1040-54

Epithelial-to-mesenchymal transition in the development and progression of adenocarcinoma and squamous cell carcinoma of the lung.

Prudkin L, Liu DD, Ozburn NC, Sun M, Behrens C, Tang X, Brown KC, Bekele BN, Moran C, Wistuba II Mod. Pathol. 2009 May 22 5 668-78

Synthesis and characterization of a high-affinity {alpha}v{beta}6-specific ligand for in vitro and in vivo applications.

Li S, McGuire MJ, Lin M, Liu YH, Oyama T, Sun X, Brown KC Mol. Cancer Ther. 2009 May 8 5 1239-49

A Novel Strategy for Surface Modification of Superparamagnetic Iron Oxide Nanoparticles for Lung Cancer Imaging.

Huang G, Zhang C, Li S, Khemtong C, Yang SG, Tian R, Minna JD, Brown KC, Gao J J Mater Chem 2009 19 6367-6372

Biopanning of phage displayed peptide libraries for the isolation of cell-specific ligands.

McGuire MJ, Li S, Brown KC Methods Mol. Biol. 2009 504 291-321

Advances in molecular imaging of pancreatic beta cells.

Lin M, Lubag A, McGuire MJ, Seliounine SY, Tsyganov EN, Antich PP, Sherry AD, Brown KC, Sun X Front. Biosci. 2008 13 4558-75

Results 1-10 of 30

Books

Featured Books Legend

Featured Books

Honors/Awards

  • Damon Runyon-Walter Winchell Foundation Postdoctoral Research Fellowship
    (1994)
  • American Chemical Society Organic Division Fellowship
    (1993)

Professional Associations/Affiliations

  • American Association of Cancer Researchers
  • American Chemical Society