Biography

My lab utilizes state-of-the-art genomic strategies to investigate the diversity of the human and mouse immune systems. Our primary focus in human genetics is to delineate the genetic basis for autoimmunity and to identify the molecular pathways that contribute to disease pathology.  Our primary focus has been on systemic lupus erythematosus (SLE), a debilitating autoimmune disease initiated via a profound loss of immunologic tolerance to nuclear antigens. We also are investigating the genetic diversity of innate immune responses in the human myeloid cell lineage. Our focus on the mouse has been in characterizing the properties of suppressive modifiers that can eliminate disease manifestations in mouse models of SLE. Currently, there are two faculty, one postdoctoral fellow and two graduate students training in the laboratory.

Education

Graduate School
University of Hawaii at Hilo (1976), Microbiology

Research Interest

  • Genetic variability in the immune system
  • Molecular genetics of susceptibility to autoimmune diseases

Publications

Featured Publications LegendFeatured Publications

T/B cell interactions are more transient in response to weak stimuli in SLE-prone mice.
Sinai P, Dozmorov IM, Song R, Schwartzberg PL, Wakeland EK, Wülfing C Eur. J. Immunol. 2014 Sep
Hunting Autoimmune Disease Genes in NOD: Early Steps on a Long Road to Somewhere Important (Hopefully).
Wakeland EK J. Immunol. 2014 Jul 193 1 3-6
Whole transcriptome RNA-seq analysis: tumorigenesis and metastasis of melanoma.
Zhao H, Li Y, Wang S, Yang Y, Wang J, Ruan X, Yang Y, Cai K, Zhang B, Cui P, Yan J, Zhao Y, Wakeland EK, Li Q, Hu S, Fang X Gene 2014 Jul
Two Functional Lupus-Associated BLK Promoter Variants Control Cell-Type- and Developmental-Stage-Specific Transcription.
Guthridge JM, Lu R, Sun H, Sun C, Wiley GB, Dominguez N, Macwana SR, Lessard CJ, Kim-Howard X, Cobb BL, Kaufman KM, Kelly JA, Langefeld CD, Adler AJ, Harley IT, Merrill JT, Gilkeson GS, Kamen DL, Niewold TB, Brown EE, Edberg JC, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá LM, Kimberly RP, Freedman BI, Stevens AM, Boackle SA, Criswell LA, Vyse TJ, Behrens TW, Jacob CO, Alarcón-Riquelme ME, Sivils KL, Choi J, Joo YB, Bang SY, Lee HS, Bae SC, Shen N, Qian X, Tsao BP, Scofield RH, Harley JB, Webb CF, Wakeland EK, James JA, Nath SK, Graham RR, Gaffney PM Am. J. Hum. Genet. 2014 Apr 94 4 586-98
Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations.
Kim-Howard X, Sun C, Molineros JE, Maiti AK, Chandru H, Adler A, Wiley GB, Kaufman KM, Kottyan L, Guthridge JM, Rasmussen A, Kelly J, Sánchez E, Raj P, Li QZ, Bang SY, Lee HS, Kim TH, Kang YM, Suh CH, Chung WT, Park YB, Choe JY, Shim SC, Lee SS, Han BG, Olsen NJ, Karp DR, Moser K, Pons-Estel BA, Wakeland EK, James JA, Harley JB, Bae SC, Gaffney PM, Alarcón-Riquelme M, Looger LL, Nath SK Hum. Mol. Genet. 2013 Oct
Transcriptome dynamics during human erythroid differentiation and development.
Yang Y, Wang H, Chang KH, Qu H, Zhang Z, Xiong Q, Qi H, Cui P, Lin Q, Ruan X, Yang Y, Li Y, Shu C, Li Q, Wakeland EK, Yan J, Hu S, Fang X Genomics 2013 Oct
Dynamic transcriptomes of human myeloid leukemia cells.
Wang H, Hu H, Zhang Q, Yang Y, Li Y, Hu Y, Ruan X, Yang Y, Zhang Z, Shu C, Yan J, Wakeland EK, Li Q, Hu S, Fang X Genomics 2013 Jun
Obesity-Associated Autoantibody Production Requires AIM to Retain the Immunoglobulin M Immune Complex on Follicular Dendritic Cells.
Arai S, Maehara N, Iwamura Y, Honda S, Nakashima K, Kai T, Ogishi M, Morita K, Kurokawa J, Mori M, Motoi Y, Miyake K, Matsuhashi N, Yamamura K, Ohara O, Shibuya A, Wakeland EK, Li QZ, Miyazaki T Cell Rep 2013 Apr 3 4 1187-98
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis.
Hinks A, Cobb J, Marion MC, Prahalad S, Sudman M, Bowes J, Martin P, Comeau ME, Sajuthi S, Andrews R, Brown M, Chen WM, Concannon P, Deloukas P, Edkins S, Eyre S, Gaffney PM, Guthery SL, Guthridge JM, Hunt SE, James JA, Keddache M, Moser KL, Nigrovic PA, Onengut-Gumuscu S, Onslow ML, Rosé CD, Rich SS, Steel KJ, Wakeland EK, Wallace CA, Wedderburn LR, Woo P, Bohnsack JF, Haas JP, Glass DN, Langefeld CD, Thomson W, Thompson SD Nat. Genet. 2013 Apr
A role for ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes.
Dutta M, Kraus ZJ, Gomez-Rodriguez J, Hwang SH, Cannons JL, Cheng J, Lee SY, Wiest DL, Wakeland EK, Schwartzberg PL J. Immunol. 2013 Mar 190 5 2121-8

Professional Associations/Affiliations

  • American Association of Immunologists
  • American Society for Microbiology
  • American Society of Biochemistry and Molecular Biology
  • Genetics Society of America
  • Mammalian Genome Society