Featured Publications
Allosteric inhibition of hypoxia inducible factor-2 with small molecules.
Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, Chen R, Garcia JA, Naidoo J, Longgood J, Frantz DE, Tambar UK, Gardner KH, Bruick RK Nat. Chem. Biol. 2013 Feb
Structural basis of photosensitivity in a bacterial light-oxygen-voltage/helix-turn-helix (LOV-HTH) DNA-binding protein.
Nash AI, McNulty R, Shillito ME, Swartz TE, Bogomolni RA, Luecke H, Gardner KH Proc. Natl. Acad. Sci. U.S.A. 2011 Jun 108 23 9449-54
Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B.
Partch CL, Gardner KH Proc. Natl. Acad. Sci. U.S.A. 2011 May 108 19 7739-44
Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.
Scheuermann TH, Tomchick DR, Machius M, Guo Y, Bruick RK, Gardner KH Proc. Natl. Acad. Sci. U.S.A. 2009 Jan 106 2 450-5
Structural basis of a phototropin light switch.
Harper SM, Neil LC, Gardner KH Science 2003 Sep 301 5639 1541-4
Development of Inhibitors of the PAS-B Domain of the HIF-2a Transcription Factor.
Rogers JL, Bayeh L, Scheuermann TH, Longgood J, Key J, Naidoo J, Melito L, Shokri C, Frantz DE, Bruick RK, Gardner KH, Macmillan JB, Tambar UK J. Med. Chem. 2013 Feb
Signaling mechanisms of LOV domains: new insights from molecular dynamics studies.
Freddolino PL, Gardner KH, Schulten K Photochem. Photobiol. Sci. 2013 Feb
Solution Structure of the WNK1 Autoinhibitory Domain, a WNK-Specific PF2 Domain.
Moon TM, Correa F, Kinch LN, Piala AT, Gardner KH, Goldsmith EJ J. Mol. Biol. 2013 Jan
Regulating the ARNT/TACC3 Axis: Multiple Approaches to Manipulating Protein/Protein Interactions with Small Molecules.
Guo Y, Partch CL, Key J, Card PB, Pashkov V, Patel A, Bruick RK, Wurdak H, Gardner KH ACS Chem. Biol. 2012 Dec
Identification of natural and artificial DNA substrates for light-activated LOV-HTH transcription factor EL222.
Rivera-Cancel G, Motta-Mena LB, Gardner KH Biochemistry 2012 Dec 51 50 10024-34
