Please note that this page is not being regularly updated, as the Gardner Lab moved to New York City in fall 2014, where Dr. Gardner directs the Structural Biology Initiative of the CUNY Advanced Science Research Center.

For more information, check out the websites for:

CUNY ASRC Structural Biology Initiative (

Kevin Gardner laboratory (

Dr. Gardner joined the UT Southwestern faculty in 1998 after B.S. (UC Davis, 1989), Ph.D. (Yale, 1995) and postdoctoral (Univ. Toronto with Lewis Kay, 1998) studies in biophysics and biochemistry.  His research group integrates structural, dynamic and kinetic information from solution NMR studies with other biophysical and biochemical data to probe the signaling mechanisms of environmental sensory proteins.  This research aims to decipher how similar proteins sense different stimuli – e.g. blue light, oxygen – to control different output functions.  Such studies lay the foundation for both understanding the natural regulation of these systems and artificially controlling them.


University of California-Davis (1989), Biochemistry
Graduate School
Yale University (1995), Biochemistry

Research Interest

  • allostery
  • artificial regulation
  • biomolecular NMR
  • cancer
  • photosensors
  • signaling
  • structural biology


Featured Publications LegendFeatured Publications

Blue Light-Induced Dimerization of a Bacterial LOV-HTH DNA-Binding Protein.
Zoltowski BD, Motta-Mena LB, Gardner KH Biochemistry 2013 Sep
Development of Inhibitors of the PAS-B Domain of the HIF-2a Transcription Factor.
Rogers JL, Bayeh L, Scheuermann TH, Longgood J, Key J, Naidoo J, Melito L, Shokri C, Frantz DE, Bruick RK, Gardner KH, Macmillan JB, Tambar UK J. Med. Chem. 2013 Feb
Signaling mechanisms of LOV domains: new insights from molecular dynamics studies.
Freddolino PL, Gardner KH, Schulten K Photochem. Photobiol. Sci. 2013 Feb
Solution Structure of the WNK1 Autoinhibitory Domain, a WNK-Specific PF2 Domain.
Moon TM, Correa F, Kinch LN, Piala AT, Gardner KH, Goldsmith EJ J. Mol. Biol. 2013 Jan
Regulating the ARNT/TACC3 Axis: Multiple Approaches to Manipulating Protein/Protein Interactions with Small Molecules.
Guo Y, Partch CL, Key J, Card PB, Pashkov V, Patel A, Bruick RK, Wurdak H, Gardner KH ACS Chem. Biol. 2012 Dec

Honors & Awards

  • Southwestern Medical School
    Excellence in Education Award (2012)
  • UT Southwestern - Postdoctoral Association
    Excellence in Postdoctoral Mentoring Award (2011)
  • Southwestern Medical School
    Excellence in Education Award (2010)
  • UT Southwestern Medical Center
    Virginia Lazenby O’Hara Chair in Biochemistry (2006)
  • The Chicago Community Trust
    Searle Scholar (1999)
  • UT Southwestern Medical Center
    W.W. Caruth, Jr. Scholar in Biomedical Research (1998)
  • Helen Hay Whitney Foundation
    Postdoctoral Fellowship (1996)
  • NIH
    NRSA Postdoctoral Fellowship (1995)
  • HHMI
    Predoctoral Fellowship - Structural Biology (1989)

Professional Associations/Affiliations

  • Biophysical Society (2005)
  • American Chemical Society (1998)