Biography

Please note that this page is not being regularly updated, as the Gardner Lab moved to New York City in fall 2014, where Dr. Gardner directs the Structural Biology Initiative of the CUNY Advanced Science Research Center.

For more information, check out the websites for:

CUNY ASRC Structural Biology Initiative (http://structbio.asrc.cuny.edu)

Kevin Gardner laboratory (http://kglab.org)

Dr. Gardner joined the UT Southwestern faculty in 1998 after B.S. (UC Davis, 1989), Ph.D. (Yale, 1995) and postdoctoral (Univ. Toronto with Lewis Kay, 1998) studies in biophysics and biochemistry.  His research group integrates structural, dynamic and kinetic information from solution NMR studies with other biophysical and biochemical data to probe the signaling mechanisms of environmental sensory proteins.  This research aims to decipher how similar proteins sense different stimuli – e.g. blue light, oxygen – to control different output functions.  Such studies lay the foundation for both understanding the natural regulation of these systems and artificially controlling them.

Education

Undergraduate
University of California-Davis (1989), Biochemistry
Graduate School
Yale University (1995), Biochemistry

Research Interest

  • allostery
  • artificial regulation
  • biomolecular NMR
  • cancer
  • photosensors
  • signaling
  • structural biology

Publications

Featured Publications LegendFeatured Publications

On the acquisition and analysis of microscale thermophoresis data.
Scheuermann TH, Padrick SB, Gardner KH, Brautigam CA Anal. Biochem. 2015 Dec 496 79-93
Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2.
Scheuermann TH, Stroud D, Sleet CE, Bayeh L, Shokri C, Wang H, Caldwell CG, Longgood J, MacMillan JB, Bruick RK, Gardner KH, Tambar UK J. Med. Chem. 2015 Jul
Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris.
Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM J. Biomol. NMR 2015 May
Ligand-induced folding of a two component signaling receiver domain.
Ocasio V, Corrêa F, Gardner KH Biochemistry 2015 Jan

Honors & Awards

  • Southwestern Medical School
    Excellence in Education Award (2012)
  • UT Southwestern - Postdoctoral Association
    Excellence in Postdoctoral Mentoring Award (2011)
  • Southwestern Medical School
    Excellence in Education Award (2010)
  • UT Southwestern Medical Center
    Virginia Lazenby O’Hara Chair in Biochemistry (2006)
  • The Chicago Community Trust
    Searle Scholar (1999)
  • UT Southwestern Medical Center
    W.W. Caruth, Jr. Scholar in Biomedical Research (1998)
  • Helen Hay Whitney Foundation
    Postdoctoral Fellowship (1996)
  • NIH
    NRSA Postdoctoral Fellowship (1995)
  • HHMI
    Predoctoral Fellowship - Structural Biology (1989)

Professional Associations/Affiliations

  • Biophysical Society (2005)
  • American Chemical Society (1998)