Dr. Mammen received his Bachelor in Science and Engineering in Bioengineering at the University of Pennsylvania and his Medical Doctorate at the University of Wisconsin-Madison. He completed an Internal Medicine Residency at the University of Iowa Hospitals & Clinics. In 1998 he arrived at UT Southwestern Medical Center where he completed Fellowships in General Clinical Cardiology, Molecular Cardiology, and Clinical Heart Failure/Cardiac Transplantation. Dr. Mammen’s clinical and scientific focus revolves around heart failure/transplantation.


Medical School University of Wisconsin School of Medicine (1995)
Internship University of Iowa Hospitals and Clinics (1996), Internal Medicine
Residency University of Iowa Hospitals and Clinics (1998), Internal Medicine
Fellowship UT Southwestern Medical Center (2001), Cardiology
Fellowship UT Southwestern Medical Center (2004), Molecular Cardiology
Fellowship UT Southwestern Medical Center (2004), Heart Failure/cardiac Transplant

Clinical Interest

  • Amyloid Cardiomyopathy
  • Arrhythmogenic Right Ventricular Cardiomyopathy
  • Dilated Cardiomyopathy
  • Familial Cardiomyopathy
  • Hypertrophic Cardiomyopathy (HOCM)
  • Ischemic Cardiomyopathy
  • Non-Compaction Cardiomyopathy
Heart Failure & Cardiac Support
  • Acute Heart Failure
  • Care of Patients with Advanced Heart Failure
  • Destination Therapy Utilizing Left Ventricular Assist Devices (LVAD)
  • Initial Cardiology Consultations for Left Ventricular Assist Devcies (LVAD)
  • Second Opinions for Advanced Heart Failure
Heart Transplant Medicine
  • Bridge Therapy Prior to Transplantation Utilizing Left Ventricular Assist Devices (LVAD)
  • Care Following Heart Transplant Patients

Research Interest

  • Cardiac energetics
  • Modulation of the metabolic and redox states with stressed cardiomyocytes
  • Oxidative stress
  • Oxygen and nitric oxide metabolism in the heart
  • Regenerative Medicine


Featured Publications LegendFeatured Publications

Association of Cystatin C with left ventricular structure and function: The Dallas Heart Study.
Patel, P.C., S.A. Murphy, R. Peshock, A. Khera, J.A. de Lemos, J.A. Balko, S Gupta, P.P.A. Mammen, M.H. Drazner, and D.W. Markham. Circulation-Heart Failure February 2009 In Press Online February 10, 2009
Hypoxia reprograms calcium signaling and regulates myoglobin expression.
Kanatous, S.B., P.P.A. Mammen, P.B. Rosenberg, C.M. Martin, M.D. White, J.M. DiMaio, G Huang, S. Muallem, and D.J. Garry American Journal of Physiology - Cell Physiology November 2008 In Press Presently online
Fulminant myocarditis.
Gupta S., D.W. Markham, M.H. Drazner, and P.P.A. Mammen Nature Clinical Practice Cardiovascular Medicine 2008 5(11) 693-706
Cytoglobin: A novel stress-responsive hemoprotein that is expressed in the developing and adult brain.
Mammen P.P.A., J.M Shelton, Q. Ye, S.B. Kanatous, A.J. McGrath, J.A. Richardson, and D.J. Garry Journal of Histochemistry & Cytochemistry 2006 54(12) 1349-1361


Featured Books Legend Featured Books

Honors & Awards

  • Postdoctoral Mentor to Sarvjeet Singh, PhD, a Finalist for the Louis N. and Arnold M. Katz Basic Science Research Award
    Highest basic science award given to a junior investigator. The award is sponsored by the American Heart Association (2010)
  • 2nd Place, Northwestern University Feinberg School of Medicine Cardiovascular Young Investigators’ Forum
    Outstanding research as a junior faculty member (2006)
  • GlaxoSmithKline Competitive Grant Award for Young Investigators
    One of four cardiovascular investigators in the nation to receive this competitive grant. (2005)
  • Above and Beyond the Call of Duty Award
    Recognition for compassionate care (U. of Iowa Hospitals & Clinics) (1998)
  • Ernest O. Theilen Award
    Outstanding Cardiac Care Unit Resident of the Year (U. of Iowa Hospitals & Clinics) (1998)

Professional Associations/Affiliations

  • American Society for Biochemistry and Molecular Biology (2008)
  • Central Society for Clinical Research (2008)
  • American College of Cardiology (2004)
  • American College of Physicians (2004)
  • American Heart Association (2004)
  • Dallas County Medical Society (2004)
  • Heart Failure Society of America (2004)
  • International Society of Heart and Lung Transplantation (2004)
  • Texas Medical Association (2004)