Dr. Mammen received his Bachelor in Science and Engineering in Bioengineering at the University of Pennsylvania and his Medical Doctorate at the University of Wisconsin-Madison. He completed an Internal Medicine Residency at the University of Iowa Hospitals & Clinics. In 1998 he arrived at UT Southwestern Medical Center where he completed Fellowships in General Clinical Cardiology, Molecular Cardiology, and Clinical Heart Failure/Cardiac Transplantation. Dr. Mammen’s clinical and scientific focus revolves around heart failure/transplantation.


Undergraduate University of Pennsylvania (1990), Biomedical Engineering
Medical School University of Wisconsin-Madison (1995), Medicine

Clinical Interest

  • Amyloid Cardiomyopathy
  • Arrhythmogenic Right Ventricular Cardiomyopathy
  • Dilated Cardiomyopathy
  • Familial Cardiomyopathy
  • Hypertrophic Cardiomyopathy (HOCM)
  • Ischemic Cardiomyopathy
  • Non-Compaction Cardiomyopathy
Heart Failure & Cardiac Support
  • Acute Heart Failure
  • Care of Patients with Advanced Heart Failure
  • Destination Therapy Utilizing Left Ventricular Assist Devices (LVAD)
  • Initial Cardiology Consultations for Left Ventricular Assist Devcies (LVAD)
  • Second Opinions for Advanced Heart Failure
Heart Transplant Medicine
  • Bridge Therapy Prior to Transplantation Utilizing Left Ventricular Assist Devices (LVAD)
  • Care Following Heart Transplant Patients

Research Interest

  • Cardiac energetics
  • Modulation of the metabolic and redox states with stressed cardiomyocytes
  • Oxidative stress
  • Oxygen and nitric oxide metabolism in the heart
  • Regenerative Medicine


Featured Publications LegendFeatured Publications

Association of Cystatin C with left ventricular structure and function: The Dallas Heart Study.

Patel, P.C., S.A. Murphy, R. Peshock, A. Khera, J.A. de Lemos, J.A. Balko, S Gupta, P.P.A. Mammen, M.H. Drazner, and D.W. Markham. Circulation-Heart Failure February 2009 In Press Online February 10, 2009

Hypoxia reprograms calcium signaling and regulates myoglobin expression.

Kanatous, S.B., P.P.A. Mammen, P.B. Rosenberg, C.M. Martin, M.D. White, J.M. DiMaio, G Huang, S. Muallem, and D.J. Garry American Journal of Physiology - Cell Physiology November 2008 In Press Presently online

Fulminant myocarditis.

Gupta S., D.W. Markham, M.H. Drazner, and P.P.A. Mammen Nature Clinical Practice Cardiovascular Medicine 2008 5(11) 693-706

Cytoglobin: A novel stress-responsive hemoprotein that is expressed in the developing and adult brain.

Mammen P.P.A., J.M Shelton, Q. Ye, S.B. Kanatous, A.J. McGrath, J.A. Richardson, and D.J. Garry Journal of Histochemistry & Cytochemistry 2006 54(12) 1349-1361


Featured Books Legend Featured Books

Honors & Awards

  • Postdoctoral Mentor to Sarvjeet Singh, PhD, a Finalist for the Louis N. and Arnold M. Katz Basic Science Research Award
    Highest basic science award given to a junior investigator. The award is sponsored by the American Heart Assoication (2010)
  • 2nd Place, Northwestern University Feinberg School of Medicine Cardiovascular Young Investigators’ Forum
    Outstanding research as a junior faculty member (2006)
  • GlaxoSmithKline Competitive Grant Award for Young Investigators
    One of four cardiovascular investigators in the nation to receive this competitive grant. (2005)
  • Above and Beyond the Call of Duty Award
    Recognition for compassionate care (U. of Iowa Hospitals & Clinics) (1998)
  • Ernest O. Theilen Award
    Outstanding Cardiac Care Unit Resident of the Year (U. of Iowa Hospitals & Clinics) (1998)

Professional Associations/Affiliations

  • American Society for Biochemistry and Molecular Biology (2008)
  • Central Society for Clinical Research (2008)
  • American College of Cardiology (2004)
  • American College of Physicians (2004)
  • American Heart Association (2004)
  • Dallas County Medical Society (2004)
  • Heart Failure Society of America (2004)
  • International Society of Heart and Lung Transplantation (2004)
  • Texas Medical Association (2004)