Pradeep Mammen, M.D.

Dr. Mammen received his Bachelor in Science and Engineering in Bioengineering at the University of Pennsylvania and his Medical Doctorate at the University of Wisconsin-Madison. He completed an Internal Medicine Residency at the University of Iowa Hospitals & Clinics. In 1998 he arrived at UT Southwestern Medical Center where he completed Fellowships in General Clinical Cardiology, Molecular Cardiology, and Clinical Heart Failure/Cardiac Transplantation. Dr. Mammen’s clinical and scientific focus revolves around heart failure/transplantation.

Medical School	University of Wisconsin School of Medicine (1995)
Internship	University of Iowa Hospitals and Clinics (1996), Internal Medicine
Residency	University of Iowa Hospitals and Clinics (1998), Internal Medicine
Fellowship	UT Southwestern Medical Center (2001), Cardiology
Fellowship	UT Southwestern Medical Center (2004), Heart Failure / Cardiac Transplant
Fellowship	UT Southwestern Medical Center (2004), Molecular Cardiology

• Advanced Congestive Heart Failure
• Heart (Cardiology)
• Heart Transplant
• Transplant

• Primary Interests
• Cardiomyopathy
• Heart Transplant
• Left or Right Heart Failure (Congestive Heart Failure)
• Left Ventricular Assist Devices (LVADS)

• Cardiac energetics
• Modulation of the metabolic and redox states with stressed cardiomyocytes
• Oxidative stress
• Oxygen and nitric oxide metabolism in the heart
• Regenerative Medicine

Featured Publications

Calcineurin activates cytoglobin transcription in hypoxic myocytes.

Singh S.*, S.M. Manda*, D. Sikder, M.J. Birrer, B.A. Rothermel, D.J. Garry, and P.P.A. Mammen. Journal of Biological Chemistry February 2009 In Press Online February 9, 2009

LXRs: Double agents in the regulation of dietary fat and cholesterol metabolism.

Kalaany N.Y, K.C. Gauthier, A.M. Zavacki, P.P.A. Mammen, T. Kitazume, J.A. Peterson, D.J. Garry, A.C. Bianco, and D.J. Mangelsdorf. Cell Metabolism 2005 1 231-244

Emerging roles of myoglobin in the heart.

Garry D.J., S.B. Kanatous, and P.P.A. Mammen Trends in Cardiovascular Medicine 2003 13 111-116

Hypoxia-induced left ventricular dysfunction in myoglobin deficient mice.

Mammen P.P.A., S.B. Kanatous, I. Yuhanna, P. W. Shaul, R.S. Balaban, M.G. Garry, and D.J. Garry Am J Physiol: Heart and Circulatory Physiology 2003 285 H2132-2141

Myocyte-enriched calcineurin interacting protein, MCIP1, inhibits cardiac hypertrophy.

Rothermel B.A., T.A. McKinsey, R.B. Vega, R.L.Nicol, P. Mammen, J. Yang, C. Antos, J.M. Shelton, R. Bassel-Duby, E.N. Olson, and R.S. Williams. Proceedings of the National Academy of Sciences USA 2001 98 3328-3333

Adaptive mechanisms that preserve cardiac function in mice without myoglobin.

Meeson A., N. Radford, J.M. Shelton, P.P.A. Mammen, Y.Kong, J.M. DiMaio, K. Hutcheson, J. Elterman, R.S. Williams, and D.J. Garry Circulation Research 2001 88 713-720

Association of Cystatin C with left ventricular structure and function: The Dallas Heart Study.

Patel, P.C., S.A. Murphy, R. Peshock, A. Khera, J.A. de Lemos, J.A. Balko, S Gupta, P.P.A. Mammen, M.H. Drazner, and D.W. Markham. Circulation-Heart Failure February 2009 In Press Online February 10, 2009

Hypoxia reprograms calcium signaling and regulates myoglobin expression.

Kanatous, S.B., P.P.A. Mammen, P.B. Rosenberg, C.M. Martin, M.D. White, J.M. DiMaio, G Huang, S. Muallem, and D.J. Garry American Journal of Physiology - Cell Physiology November 2008 In Press Presently online

Fulminant myocarditis.

Gupta S., D.W. Markham, M.H. Drazner, and P.P.A. Mammen Nature Clinical Practice Cardiovascular Medicine 2008 5(11) 693-706

Cytoglobin: A novel stress-responsive hemoprotein that is expressed in the developing and adult brain.

Mammen P.P.A., J.M Shelton, Q. Ye, S.B. Kanatous, A.J. McGrath, J.A. Richardson, and D.J. Garry Journal of Histochemistry & Cytochemistry 2006 54(12) 1349-1361

Featured Books

Molecular insights into the functional role of myoglobin.. In Hypoxia and the Circulation

Garry, D.J. and P.P.A. Mammen (2007). Springer

• Postdoctoral Mentor to Sarvjeet Singh, PhD, a Finalist for the Louis N. and Arnold M. Katz Basic Science Research Award
  Highest basic science award given to a junior investigator. The award is sponsored by the American Heart Assoication (2010)
• 2nd Place, Northwestern University Feinberg School of Medicine Cardiovascular Young Investigators’ Forum
  Outstanding research as a junior faculty member (2006)
• GlaxoSmithKline Competitive Grant Award for Young Investigators
  One of four cardiovascular investigators in the nation to receive this competitive grant. (2005)
• Above and Beyond the Call of Duty Award
  Recognition for compassionate care (U. of Iowa Hospitals & Clinics) (1998)
• Ernest O. Theilen Award
  Outstanding Cardiac Care Unit Resident of the Year (U. of Iowa Hospitals & Clinics) (1998)

• American Society for Biochemistry and Molecular Biology (2008)
• Central Society for Clinical Research (2008)
• American College of Cardiology (2004)
• American College of Physicians (2004)
• American Heart Association (2004)
• Dallas County Medical Society (2004)
• Heart Failure Society of America (2004)
• International Society of Heart and Lung Transplantation (2004)
• Texas Medical Association (2004)