Venkateswara Mootha, M.D. Professor Endowed Title Paul T. Stoffel / Centex Professorship in Clinical Care School Medical School Department Ophthalmology | Eugene McDermott Center for Human Growth and Development Graduate Programs Genetics, Development and Disease You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Education Medical School Johns Hopkins University School of Medicine (1993) Internship St. Joseph's Hospital (1994), Transitional Year Residency University of Wisconsin Hospital and Clinics (1997), Ophthalmology Fellowship UT Southwestern Medical School (1999), Cornea & External Diseases Research Interest Cataract surgery Endothelial keratoplasty Fuchs' Endothelial Corneal Dystrophy Genetics of corneal disorders Repeat RNA in Age-Related Degenerative Disease Publications Featured Publications Analyzing pre-symptomatic tissue to gain insights into the molecular and mechanistic origins of late-onset degenerative trinucleotide repeat disease. Chu Y, Hu J, Liang H, Kanchwala M, Xing C, Beebe W, Bowman CB, Gong X, Corey DR, Mootha VV, Nucleic Acids Res. 2020 May Delivery of Antisense Oligonucleotides to the Cornea. Chau VQ, Hu J, Gong X, Hulleman JD, Ufret-Vincenty RL, Rigo F, Prakash TP, Corey DR, Mootha VV, Nucleic Acid Ther 2020 Mar Oligonucleotides Targeting TCF4 Triplet Repeat Expansion Inhibit RNA Foci and Mis-splicing in Fuchs' Dystrophy. Hu J, Rong Z, Gong X, Zhou Z, Sharma VK, Xing C, Watts JK, Corey DR, Mootha VV Hum. Mol. Genet. 2018 Jan Fuchs' Endothelial Corneal Dystrophy and RNA Foci in Patients With Myotonic Dystrophy. Mootha VV, Hansen B, Rong Z, Mammen PP, Zhou Z, Xing C, Gong X Invest. Ophthalmol. Vis. Sci. 2017 Sep 58 11 4579-4585 Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy. Afshari NA, Igo RP, Morris NJ, Stambolian D, Sharma S, Pulagam VL, Dunn S, Stamler JF, Truitt BJ, Rimmler J, Kuot A, Croasdale CR, Qin X, Burdon KP, Riazuddin SA, Mills R, Klebe S, Minear MA, Zhao J, Balajonda E, Rosenwasser GO, Baratz KH, Mootha VV, Patel SV, Gregory SG, Bailey-Wilson JE, Price MO, Price FW, Craig JE, Fingert JH, Gottsch JD, Aldave AJ, Klintworth GK, Lass JH, Li YJ, Iyengar SK Nat Commun 2017 Mar 8 14898 Congenital Corneal Endothelial Dystrophies Resulting From Novel De Novo Mutations. Cunnusamy K, Bowman CB, Beebe W, Gong X, Hogan RN, Mootha VV Cornea 2016 Feb 35 2 281-5 A novel H395R mutation in MKKS/BBS6 causes retinitis pigmentosa and polydactyly without other findings of Bardet-Biedl or McKusick-Kaufman syndrome. Hulleman JD, Nguyen A, Ramprasad VL, Murugan S, Gupta R, Mahindrakar A, Angara R, Sankurathri C, Mootha VV Mol. Vis. 2016 22 73-81 Correlation of Severity of Fuchs Endothelial Corneal Dystrophy With Triplet Repeat Expansion in TCF4. Soliman AZ, Xing C, Radwan SH, Gong X, Mootha VV JAMA Ophthalmol 2015 Sep 1-6 TCF4 Triplet Repeat Expansion and Nuclear RNA Foci in Fuchs' Endothelial Corneal Dystrophy. Mootha VV, Hussain I, Cunnusamy K, Graham E, Gong X, Neelam S, Xing C, Kittler R, Petroll WM Invest. Ophthalmol. Vis. Sci. 2015 Feb Impact of Donor Age on Corneal Endothelium-Descemet Membrane Layer Scroll Formation. Bennett A, Mahmoud S, Drury D, Cavanagh HD, McCulley JP, Petroll WM, Mootha VV Eye Contact Lens 2015 Jan Results 1-10 of 63 1 2 3 4 5 Next Last Honors & Awards Achievement AwardAmerican Academy of Ophthalmology (2020) Top Award, $50,000 grant in the UT Southwestern Biotech Track of the Big Idea CompetitionUT Dallas Institute for Innovation and Entrepreneurship and Texas Startups Roadshow (2020) Harrington Scholar-Innovator AwardHarrington Discovery Institute (2018) Cornea SocietyMember with thesis (2010) North & Central Texas Clinical and Translational Science InitiativePilot Grant Award Recipient (2010) Professional Associations/Affiliations American Academy of Ophthalmology Association for Research in Vision and Ophthalmology
