Medical School
American University - Beirut (1995)
American University of Beruit (1996), Pediatrics
American University of Beruit (1998), Pediatrics
UT Southwestern Medical Center (2001), Neonatal-perinatal Medicine
Children's Health Dallas (2002), Pediatrics
Children's Health Dallas (2004), Pediatrics

Specialty Areas

Clinical Interest

  • Asphyxia
  • Neonatal Neurology
  • Neonatal Resuscitation
  • Research Interest

    • neonatal brain injury, asphyxia, hypothermia


    Featured Publications LegendFeatured Publications

    Hypothermia for neonatal hypoxic-ischemic encephalopathy: NICHD Neonatal Research Network contribution to the field.
    Shankaran S, Natarajan G, Chalak L, Pappas A, McDonald SA, Laptook AR Semin. Perinatol. 2016 Jun
    Early Development of Functional Network Segregation Revealed by Connectomic Analysis of the Preterm Human Brain.
    Cao M, He Y, Dai Z, Liao X, Jeon T, Ouyang M, Chalak L, Bi Y, Rollins N, Dong Q, Huang H Cereb. Cortex 2016 Mar
    The impact of ambient operating room temperature on neonatal and maternal hypothermia and associated morbidities: a randomized controlled trial.
    Duryea EL, Nelson DB, Wyckoff MH, Grant EN, Tao W, Sadana N, Chalak LF, McIntire DD, Leveno KJ Am. J. Obstet. Gynecol. 2016 Feb
    Cerebral Hemodynamics in Asphyxiated Newborns Undergoing Hypothermia Therapy: Pilot Findings Using a Multiple-Time-Scale Analysis.
    Chalak LF, Tian F, Tarumi T, Zhang R Pediatr. Neurol. 2016 Feb 55 30-6
    Wavelet coherence analysis of dynamic cerebral autoregulation in neonatal hypoxic-ischemic encephalopathy.
    Tian F, Tarumi T, Liu H, Zhang R, Chalak L Neuroimage Clin 2016 11 124-32
    Structural Development of Human Fetal and Preterm Brain Cortical Plate Based on Population-Averaged Templates.
    Yu Q, Ouyang A, Chalak L, Jeon T, Chia J, Mishra V, Sivarajan M, Jackson G, Rollins N, Liu S, Huang H Cereb. Cortex 2015 Sep
    Placental Pathology is Associated with Severity of Neonatal Encephalopathy and Adverse Developmental Outcomes following Hypothermia.
    Mir IN, Johnson-Welch SF, Nelson DB, Brown LS, Rosenfeld CR, Chalak LF Am. J. Obstet. Gynecol. 2015 Sep
    T1 and T2 values of human neonatal blood at 3 Tesla: Dependence on hematocrit, oxygenation, and temperature.
    Liu P, Chalak LF, Krishnamurthy LC, Mir I, Peng SL, Huang H, Lu H Magn Reson Med 2015 May
    Structural development of human brain white matter from mid-fetal to perinatal stage.
    Ouyang A, Yu Q, Mishra V, Chalak L, Jeon T, Sivarajan M, Jackson G, Rollins N, Liu S, Huang H Proc SPIE Int Soc Opt Eng 2015 Feb 9417
    Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic ischemic encephalopathy: a randomized clinical trial.
    Shankaran S, Laptook AR, Pappas A, McDonald SA, Das A, Tyson JE, Poindexter BB, Schibler K, Bell EF, Heyne RJ, Pedroza C, Bara R, Van Meurs KP, Grisby C, Huitema CM, Garg M, Ehrenkranz RA, Shepherd EG, Chalak LF, Hamrick SE, Khan AM, Reynolds AM, Laughon MM, Truog WE, Dysart KC, Carlo WA, Walsh MC, Watterberg KL, Higgins RD JAMA 2014 Dec 24-31 312 24 2629-39

    Honors & Awards

    • Elected member, Society of Pediatric Research
    • PRS Young Research Investigator Award
      Perinatal Research Society (2010)

    Professional Associations/Affiliations

    • International Perinatal Collegium (2015)
    • Perinatal Research Society (2014)
    • Society for Pediatric Research (2011)