Makoto Kuro-O, M.D., Ph.D.

Higher Education:

1985 MD, University of Tokyo

1991 PhD, University of Tokyo

Academic Appointments:

1985-86 Intern, Tokyo University Hospital.

1986-87 Intern, Tokyo Metropolitan Geriatric Hospital.

1987-88 Resident in Internal Medicine (Cardiology), Tokyo Metropolitan Geriatric Hospital.

1988-91 Clinical Fellow, the 3rd Department of Internal Medicine, University of Tokyo.

1991-94 Postdoctoral Fellow, Division of Molecular Genetics, National Institute of Neuroscience, NCNP, Tokyo, Japan.

1994-98 Domestic Research Fellow, Division of Molecular Genetics, National Institute of Neuroscience, NCNP, Tokyo, Japan.

1998-06 Assistant Professor of Pathology, UT Southwestern.

2006- Associate Professor, UT Southwestern.

Medical School	University of Tokyo - Japan (1985), Medicine
Graduate School	University of Tokyo - Japan (1991)

• Endocrinology, Endocrine FGF
• Molecular Biology of Aging
• Nephrology, Mineral metabolism

Featured Publications

Suppression of Aging in Mice by the Hormone Klotho

Kurosu H, et al. Science August 2005 309 1829-1833

Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima Y Nature November 1997 390 45-51

Beta-Klotho is required for metabolic activity of fibroblast growth factor 21

Ogawa, Y., Kurosu, H., Yamamoto, M., Nandi, A., Rosenblatt, K. P., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Kuro-o, M. Proc Natl Acad Sci U S A May 2007 104 7432-7437

Regulation of fibroblast growth factor-23 signaling by Klotho

Kurosu H et al. J Biol Chem March 2006 281 6120-6123

Regulation of oxidative stress by the anti-aging hormone Klotho

Yamamoto M, et al. J Biol Chem September 2005 280 38029-38034

Suppression of Aging in Mice by the Hormone Klotho

Kurosu H, et al. Science August 2005 309 1829-1833

Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima Y Nature November 1997 390 45-51

• President's Research Council Distinguished Young Researcher Award
  UT Southwestern (1999)
• Erwin von Belz Preis
  Boehringer Ingelheim (1998)
• Irvine H. Page Arteriosclerosis Research Awards for Young Investigators
  American Heart Association (1997)