Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase
Bao-Liang Song, Navdar Sever, and Russell A. DeBose-Boyd Molecular Cell September 2005 19 829-840
Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol
Bao-Liang Song, Norman B. Javitt, and Russell A. DeBose-Boyd Cell Metabolism March 2005 1 179-189
Ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase
Bao-Liang Song and Russell A. DeBose-Boyd Journal of Biological Chemistry July 2004 279 28798-28806
Accelerated Degradation of HMG CoA Reductase Mediated by Binding of Insig-1 to its Sterol-Sensing Domain
Sever, N., Yang, T., Brown, M.S., Goldstein, J.L., and DeBose-Boyd, R.A Molecular Cell 2003 11 25-33
Transport-dependent proteolysis of SREBP: Relocation of Site-1 Protease from Golgi to ER obviates the need for SREBP transport to Golgi
DeBose-Boyd, R.A., Brown, M.S., Li, W.-P., Nohturfft, A., Goldstein, J.L., and Espenshade, P.J. Cell 1999 99 703-712
Intramembrane glycine mediates multimerization of insig-2, a requirement for sterol regulation in chinese hamster ovary cells.
Lee, P.C., Debose-Boyd, R.A. J. Lipid Res. 2010 51 192-201
Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase.
Jo, Y., Debose-Boyd, R.A. Crit. Rev. Biochem. Mol. Biol. 2010 45 185-98
Sterol-induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Endoplasmic Reticulum Membranes into the Cytosol through a Subcellular Compartment Resembling Lipid Droplets.
Hartman, I.Z., Liu, P., Zehmer, J.K., Luby-Phelps, K., Jo, Y., Anderson, R.G., Debose-Boyd, R.A. J. Biol. Chem. 2010 285 19288-98
Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells.
Nguyen, A.D., Lee, S.H., DeBose-Boyd, R.A. J. Biol. Chem. September 2009 284 26778-88
Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase.
DeBose-Boyd, R.A. Cell Res. 2008 18 609-21