Dr. DeBose-Boyd was born and raised in a small rural southeastern Oklahoma community (population 700) where he graduated from Boswell High School, Boswell, Oklahoma in 1989. Soon thereafter, he began undergraduate studies at Southeastern Oklahoma State University (SOSU) in Durant, OK, where he participated in the Minority Biomedical Research Support program.Dr. DeBose-Boyd obtained a Bachelor of Science degree in Chemistry with minors in Mathematics and Biology in 1993.

Upon completion of undergraduate studies, he was accepted into the Department of Biochemistry and Molecular Biology at the University of Oklahoma Health Sciences Center, and joined the laboratory of Richard D. Cummings, PhD. In 1998, he successfully defended his thesis, entitled "Identification, characterization, and molecular cloning of alpha 1,3 fucosyltransferases in parasitic and non-parasitic helminths."

Following his defense, Dr. DeBose-Boyd joined the laboratory of Joseph L. Goldstein, M.D. and Michael S. Brown, M.D. at UT Southwestern as a fellow of the Jane Coffin Childs Memorial Fund for Medical Research. Dr. DeBose-Boyd is married to Gwendolyn and has two sons, Reginald and Ryan.


Southeastern Oklahoma State Un (1993), Chemistry
Graduate School
University of Oklahoma-Hlth Sc (1998), Biochemistry

Research Interest

  • Cell Regulation
  • Cholesterol homeostasis
  • Endoplasmic Reticulum Associated Degradation
  • Multivalent feedback regulation of HMG CoA reductase


Featured Publications LegendFeatured Publications

Intramembrane glycine mediates multimerization of insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.
Lee, P.C., Debose-Boyd, R.A. J. Lipid Res. 2010 51 192-201
Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase.
Jo, Y., Debose-Boyd, R.A. Crit. Rev. Biochem. Mol. Biol. 2010 45 185-98
Sterol-induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Endoplasmic Reticulum Membranes into the Cytosol through a Subcellular Compartment Resembling Lipid Droplets.
Hartman, I.Z., Liu, P., Zehmer, J.K., Luby-Phelps, K., Jo, Y., Anderson, R.G., Debose-Boyd, R.A. J. Biol. Chem. 2010 285 19288-98
Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells.
Nguyen, A.D., Lee, S.H., DeBose-Boyd, R.A. J. Biol. Chem. September 2009 284 26778-88
Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase.
DeBose-Boyd, R.A. Cell Res. 2008 18 609-21

Honors & Awards

  • Early Career Scientist Award, Howard Hughes Medical Institute
  • W.M. Keck Distinguished Young Scholar in Medical Research
  • David L. Williams Memorial Lectureship Award
  • Established Investigator of American Heart Association
  • Fellow of The Jane Coffin Childs Memorial Fund for Medical Research