Dr. DeBose-Boyd was born and raised in a small rural southeastern Oklahoma community (population 700) where he graduated from Boswell High School, Boswell, Oklahoma in 1989. Soon thereafter, he began undergraduate studies at Southeastern Oklahoma State University (SOSU) in Durant, OK, where he participated in the Minority Biomedical Research Support program.Dr. DeBose-Boyd obtained a Bachelor of Science degree in Chemistry with minors in Mathematics and Biology in 1993.
Upon completion of undergraduate studies, he was accepted into the Department of Biochemistry and Molecular Biology at the University of Oklahoma Health Sciences Center, and joined the laboratory of Richard D. Cummings, PhD. In 1998, he successfully defended his thesis, entitled "Identification, characterization, and molecular cloning of alpha 1,3 fucosyltransferases in parasitic and non-parasitic helminths."
Following his defense, Dr. DeBose-Boyd joined the laboratory of Joseph L. Goldstein, M.D. and Michael S. Brown, M.D. at UT Southwestern as a fellow of the Jane Coffin Childs Memorial Fund for Medical Research. Dr. DeBose-Boyd is married to Gwendolyn and has two sons, Reginald and Ryan.
- Southwestern Oklahoma State University (1993), Chemistry
- Graduate School
- University of Oklahoma Health Sciences Center (1998), Biochemistry
- Cell Regulation
- Cholesterol homeostasis
- Endoplasmic Reticulum Associated Degradation
- Multivalent feedback regulation of HMG CoA reductase
- Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase
- Bao-Liang Song, Navdar Sever, and Russell A. DeBose-Boyd Molecular Cell September 2005 19 829-840
- Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol
- Bao-Liang Song, Norman B. Javitt, and Russell A. DeBose-Boyd Cell Metabolism March 2005 1 179-189
- Ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase
- Bao-Liang Song and Russell A. DeBose-Boyd Journal of Biological Chemistry July 2004 279 28798-28806
- Accelerated Degradation of HMG CoA Reductase Mediated by Binding of Insig-1 to its Sterol-Sensing Domain
- Sever, N., Yang, T., Brown, M.S., Goldstein, J.L., and DeBose-Boyd, R.A Molecular Cell 2003 11 25-33
- Transport-dependent proteolysis of SREBP: Relocation of Site-1 Protease from Golgi to ER obviates the need for SREBP transport to Golgi
- DeBose-Boyd, R.A., Brown, M.S., Li, W.-P., Nohturfft, A., Goldstein, J.L., and Espenshade, P.J. Cell 1999 99 703-712
- Intramembrane glycine mediates multimerization of insig-2, a requirement for sterol regulation in Chinese hamster ovary cells.
- Lee, P.C., Debose-Boyd, R.A. J. Lipid Res. 2010 51 192-201
- Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase.
- Jo, Y., Debose-Boyd, R.A. Crit. Rev. Biochem. Mol. Biol. 2010 45 185-98
- Sterol-induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Endoplasmic Reticulum Membranes into the Cytosol through a Subcellular Compartment Resembling Lipid Droplets.
- Hartman, I.Z., Liu, P., Zehmer, J.K., Luby-Phelps, K., Jo, Y., Anderson, R.G., Debose-Boyd, R.A. J. Biol. Chem. 2010 285 19288-98
- Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells.
- Nguyen, A.D., Lee, S.H., DeBose-Boyd, R.A. J. Biol. Chem. September 2009 284 26778-88
- Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase.
- DeBose-Boyd, R.A. Cell Res. 2008 18 609-21
Honors & Awards
- Early Career Scientist Award, Howard Hughes Medical Institute
- W.M. Keck Distinguished Young Scholar in Medical Research
- David L. Williams Memorial Lectureship Award
- Established Investigator of American Heart Association
- Fellow of The Jane Coffin Childs Memorial Fund for Medical Research