Russell DeBose-Boyd, Ph.D. Titles and Appointments Professor Endowed Title Beatrice and Miguel Elias Distinguished Chair in Biomedical Science School Graduate School Department Molecular Genetics | Office of the Provost Graduate Programs Biological Chemistry, Cell and Molecular Biology Biography Russell DeBose-Boyd, Ph. D. is the Beatrice and Miguel Elias Distinguished Chair in Biomedical Science, Professor of Molecular Genetics, and Assistant Dean for Research Advancement at the University of Texas Southwestern Medical Center in Dallas, TX. He earned his B.S. in Chemistry from Southeastern Oklahoma State University and his Ph.D. in Biochemistry and Molecular Biology from the University of Oklahoma Health Sciences Center. Dr. DeBose-Boyd joined the laboratory of Joseph Goldstein, M.D. and Michael Brown, M.D. at the University of Texas Southwestern Medical Center as a postdoctoral fellow and joined the Department of Molecular Genetics faculty in 2003. He has been named an Established Investigator of the American Heart Association, a W.M. Keck Distinguished Young Scholar in Medical Research, and a Howard Hughes Medical Institute Early Career Scientist. Dr. DeBose-Boyd’s awards include the Jane Coffin Childs Memorial Postdoctoral Fellowship, David L. Williams Memorial Lectureship Award, John J. Abel Award in Pharmacology, DeWitt Goodman Lectureship Award, Edward Bierman Award from the American Diabetes Association, David S. Sigman Lectureship Award, the Avanti Award in Lipids, and the inaugural Hill Prize in Biological Sciences. In 2023, Dr. DeBose-Boyd was elected to the United States National Academy of Sciences. Education Undergraduate Southeastern Oklahoma St Univ (1993), Chemistry Graduate School Uni of Oklahoma-Hlth Sci Ctr (1998), Biochemistry Research Interest Cell Regulation Cholesterol homeostasis Endoplasmic Reticulum Associated Degradation Multivalent feedback regulation of HMG CoA reductase Publications Featured Publications Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase. DeBose-Boyd, R.A. Cell Res. 2008 18 609-21 Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase Bao-Liang Song, Navdar Sever, and Russell A. DeBose-Boyd Molecular Cell September 2005 19 829-840 Ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase Bao-Liang Song and Russell A. DeBose-Boyd Journal of Biological Chemistry July 2004 279 28798-28806 Accelerated Degradation of HMG CoA Reductase Mediated by Binding of Insig-1 to its Sterol-Sensing Domain Sever, N., Yang, T., Brown, M.S., Goldstein, J.L., and DeBose-Boyd, R.A Molecular Cell 2003 11 25-33 Transport-dependent proteolysis of SREBP: Relocation of Site-1 Protease from Golgi to ER obviates the need for SREBP transport to Golgi DeBose-Boyd, R.A., Brown, M.S., Li, W.-P., Nohturfft, A., Goldstein, J.L., and Espenshade, P.J. Cell 1999 99 703-712 Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain. Chen H, Qi X, Faulkner RA, Schumacher MM, Donnelly LM, DeBose-Boyd RA, Li X, Nat Commun 2022 Jul 13 1 4273 Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1. Elsabrouty R, Jo Y, Hwang S, Jun DJ, DeBose-Boyd RA, Elife 2021 Nov 10 Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption. Long T, Liu Y, Qin Y, DeBose-Boyd RA, Li X, Sci Adv 2021 Aug 7 34 Posttranslational Regulation of HMG CoA Reductase, the Rate-Limiting Enzyme in Synthesis of Cholesterol. Schumacher MM, DeBose-Boyd RA, Annu Rev Biochem 2021 Jun 90 659-679 Schnyder Corneal Dystrophy-Associated UBIAD1 is Defective in MK-4 Synthesis and Resists Autophagy-Mediated Degradation. Jun DJ, Schumacher MM, Hwang S, Kinch LN, Grishen NV, DeBose-Boyd RA, J. Lipid Res. 2020 Mar Results 1-10 of 37 1 2 3 4 Next Last Honors & Awards Hill Prize in Biological SciencesTexas Academy of Medicine, Engineering, Science, and Technology (2024) Avanti Award in LipidsAmerican Society for Biochemistry and Molecular Biology (2023) Member, United States National Academy of Sciences (2023) David S. Sigman Lectureship AwardUCLA Molecular Biology Institute (2022) Edward Bierman AwardAmerican Diabetes Association (2021) DeWitt Goodman Lectureship in Nutrition and Regenerative MedicineColumbia University Medical Center (2019) John J. Abel Award in PharmacologyAmerican Society for Pharmacology and Experimental Therapeutics (2010) Early Career Scientist AwardHoward Hughes Medical Institute (2009) W.M. Keck Distinguished Young Scholar in Medical ResearchW.M. Keck Foundation (2006) David L. Williams Memorial Lectureship AwardKern Lipid Conference (2005) Established InvestigatorAmerican Heart Association (2005) Fellow of The Jane Coffin Childs Memorial Fund for Medical Research (1998)
