Thomas Gillette, Ph.D. Associate Professor School Medical School Department Internal Medicine Graduate Programs Cell and Molecular Biology Biography Thomas Gillette, Ph.D., is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of the Division of Cardiology. Originally from Islip, New York, Dr. Gillette holds a bachelor's degree in biology from Manhattanville Collee in Purchase, New York. He completed his postdoctorate education in biochemistry at the New York University Medical Center Sackler Institute. He went on to do postdoctoral fellowships under Drs. Errol Friedberg and Stephen Johnston at UT Southwestern Medical Center. Dr. Gillette joined the UT Southwestern faculty in 2004 as an Instructor of Physiology. He was promoted to Assistant Professor of Physiology in 2005, then Assistant Professor of Internal Medicine in 2009. He has been an Associate Professor of Internal Medicine since 2016. At UT Southwestern, Dr. Gillette has co-mentored numerous trainees in coordination with Dr. Joseph Hill. Dr. Gillette's research interests include heart failure, regulating cardiac function, ischemia/reperfusion injury, and cardiac hypertrophy. His findings have resulted in numerous peer-reviewed publications, reviews, book chapters, lectures, and editorials. Dr. Gillette is a member of the American Heart Association's Council on Basic Cardiovascular Sciences. Education Undergraduate Manhattanville College (1986), Biology Graduate School New York University (1998), Biology Research Interest Autophagy Cardiac Hypertrophy Cardiac remodeling epigenetics Heart Failure Ischemia/Repurfusion Injury Ubiquitin Proteasome Pathway Publications Featured Publications Nitrosative stress drives heart failure with preserved ejection fraction. Schiattarella GG, Altamirano F, Tong D, French KM, Villalobos E, Kim SY, Luo X, Jiang N, May HI, Wang ZV, Hill TM, Mammen PPA, Huang J, Lee DI, Hahn VS, Sharma K, Kass DA, Lavandero S, Gillette TG, Hill JA, Nature 2019 Apr 568 7752 351-356 Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification. Li DL, Wang ZV, Ding G, Tan W, Luo X, Criollo A, Xie M, Jiang N, May H, Kyrychenko V, Schneider JW, Gillette TG, Hill JA Circulation 2016 Mar Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression. Morales CR, Li DL, Pedrozo Z, May HI, Jiang N, Kyrychenko V, Cho GW, Kim SY, Wang ZV, Rotter D, Rothermel BA, Schneider JW, Lavandero S, Gillette TG, Hill JA Sci Signal 2016 9 422 ra34 Readers, Writers, and Erasers: Chromatin as the Whiteboard of Heart Disease. Gillette TG, Hill JA Circ. Res. 2015 Mar 116 7 1245-1253 Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway. Wang ZV, Deng Y, Gao N, Pedrozo Z, Li DL, Morales CR, Criollo A, Luo X, Tan W, Jiang N, Lehrman MA, Rothermel BA, Lee AH, Lavandero S, Mammen PP, Ferdous A, Gillette TG, Scherer PE, Hill JA Cell 2014 Mar 156 6 1179-92 HDAC Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy. Xie M, Kong Y, Tan W, May H, Battiprolu PK, Pedrozo Z, Wang Z, Morales C, Luo X, Cho G, Jiang N, Jessen ME, Warner JJ, Lavandero S, Gillette TG, Turer AT, Hill JA Circulation 2014 Jan PKG Primes the Proteasome. Gillette TG, Hill JA Circulation 2013 Jun Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice. Battiprolu PK, Hojayev B, Jiang N, Wang ZV, Luo X, Iglewski M, Shelton JM, Gerard RD, Rothermel BA, Gillette TG, Lavandero S, Hill JA J. Clin. Invest. 2012 Mar 122 3 1109-18 Epigenetic regulation in heart failure. Kim SY, Morales CR, Gillette TG, Hill JA Curr. Opin. Cardiol. 2016 Mar Pharmacological priming of adipose-derived stem cells promotes myocardial repair. Burchfield JS, Paul AL, Lanka V, Tan W, Kong Y, McCallister C, Rothermel BA, Schneider JW, Gillette TG, Hill JA J. Investig. Med. 2016 Jan 64 1 50-62 Results 1-10 of 31 1 2 3 4 Next Last Honors & Awards American Heart Association Council On Basic Cardiovascular Sciences (2015) Professional Associations/Affiliations American Heart Association Council On Basic Cardiovascular Sciences (2015)
