Ezra Burstein, M.D.

Download Curriculum Vitae

Dr. Burstein received his medical degree from Cayetano Heredia University in Lima, Peru.  He completed his Internal Medicine residency training at UT Southwestern Medical School and a Gastroenterology fellowship at the University of Michigan Medical School.  Thereafter, he was also a research fellow at the Vaccine Research Center at the National Institutes of Health.  After completion of his training, he joined the Faculty at University of Michigan (2001-2008), and was later recruited to UT Southwestern, joining the Departments of Internal Medicine (Division of Digestive and Liver Diseases) and Molecular Biology. Dr. Burstein′s research interests include the molecular regulation of the inflammatory response, particularly in the intestinal tract, and ubiquitination events targeting the NF-kB transcription factor.  

Medical School	Cayetano Heredia Peruvian University (1994)
Residency	UT Southwestern Medical Center (1998), Internal Medicine
Fellowship	University of Michigan Hospitals & Health Centers (2001), Gastroenterology

• COMMD proteins
• Inflammation, particularly in the intestinal tract
• NF-kB regulation

Featured Publications

COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion.

van de Sluis B, Mao X, Zhai Y, Groot AJ, Vermeulen JF, van der Wall E, van Diest PJ, Hofker MH, Wijmenga C, Klomp LW, Cho KR, Fearon ER, Vooijs M, Burstein E. The Journal of Clinical Investigation June 2010 120 6 2119-2130

GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA.

Mao X, Gluck N, Li D, Maine GN, Li H, Zaidi IW, Repaka A, Mayo MW, Burstein E Genes and Development April 2009 23 7 849-861

COMMD1 promotes the ubiquitination of NF-kB subunits through a cullin containing ubiquitin ligase

Maine GN, Mao X, Komarck CM, Burstein E EMBO Journal January 2007 26 2 459-467

A novel role for XIAP in copper homeostasis through regulation of MURR1

Burstein E, Ganesh L, Dick RD, Brewer GJ, van De Sluis B, Wilkinson J, Lewis J, Klomp LWJ, Wijmenga C, Nabel GJ, Duckett CS EMBO Journal January 2004 23 1 244-254

The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes

Ganesh L, Burstein E, Guha-Niyogi A, Louder M, Mascola J, Klomp LWJ, Wijmenga C, Duckett CS, Nabel GJ Nature December 2003 426 6968 853-857

Regulation of NF-kappaB activity by competition between RelA acetylation and ubiquitination.

Li H, Wittwer T, Weber A, Schneider H, Moreno R, Maine GN, Kracht M, Schmitz ML, Burstein E. Oncogene February 2012 31 5

A bimolecular affinity purification method under denaturing conditions for rapid isolation of a ubiquitinated protein for mass spectrometry analysis

Maine GN, Zaidi IW, Li H, Basrur V, Elenitoba-Johnson K, Burstein E. Nature Protocols August 2010 5 8 1447-1459

XIAP is copper binding protein deregulated in Wilson′s disease and other copper toxicosis disorders

Mufti AR, Burstein E, Csomos RA, Graf TCF, Wilkinson JC, Dick RD, Challa M, Son JK, Bratton SB, Su GL, Brewer GJ, Jakob U, Duckett CS Molecular Cell March 2006 21 6 775-785

• Member
  The American Society for Clinical Investigation (ASCI) (2012)
• Helmsley Scholar
  Crohn’s and Colitis Foundation of America (2010)
• AGA Research Scholar Award
  Foundation for Digestive Health and Nutrition (2003)
• John S. Miller Award
  Outstanding Performance as a House Officer, UT Southwestern Medical School (1998)
• Valedictorian
  Medical School of Cayetano Heredia University (1994)