Biography

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Dr. Burstein received his medical degree from Cayetano Heredia University in Lima, Peru.  He completed Internal Medicine residency training at UT Southwestern and Gastroenterology fellowship training at the University of Michigan.  Thereafter, he was also a research fellow at the Vaccine Research Center at the NIH. After completion of his training, he joined the Faculty at University of Michigan (2002-2008), and was later recruited to UT Southwestern, joining the Departments of Internal Medicine (Division of Digestive and Liver Diseases) and Molecular Biology. 

Dr. Burstein′s research training and expertise is in the area of molecular immunology.  Broadly, the work in his laboratory is focused on basic mechanisms that control inflammatory responses in human disease, particularly inflammatory bowel disease (IBD).  Work from the laboratory has investigated the regulation of the NF-kB transcription factor, which led to the discovery of the COMMD protein family.  Thereafter, his group has also investigated the basic functions of these factors in immune regulation, including the recent discovery of their role in endosomal protein sorting. More recently, the lab began investigating the genetic and molecular basis of altered immunity in patients with defined Mendelian disorders.  These studies have led to important discoveries, including the identification of cytosolic RNA:DNA hybrids as regulators of the interferon pathway.

Education

Medical School
Cayetano Heredia Peruvian University (1994)
Residency
UT Southwestern Medical Center (1998), Internal Medicine
Fellowship
University of Michigan Hospitals & Health Centers (2001), Gastroenterology
Graduate School
University of Groningen (2013), Molecular Genetics

Specialty Areas

Clinical Interest

  • Celiac Disease
  • Crohn's Disease
  • Familial Adeomatous Polyposis (FAP)
  • Hereditary Non-Polyposis Colorectal Cancer
  • Inflammatory Bowel Disease (IBD)
  • Lynch Syndrome
  • MYH Polyposis Syndrome
  • Ulcerative Colitis
  • Research Interest

    • COMMD proteins
    • Genetics of inflammatory disorders
    • Inflammation, particularly in the intestinal tract

    Publications

    Featured Publications LegendFeatured Publications

    Copper Metabolism Domain-containing 1 Represses Genes that Promote Inflammation and Protects Mice From Colitis and Colitis-associated Cancer.
    Li H, Chan L, Bartuzi P, Melton SD, Weber A, Ben-Shlomo S, Varol C, Raetz M, Mao X, Starokadomskyy P, van Sommeren S, Mokadem M, Schneider H, Weisberg R, Westra HJ, Esko T, Metspalu A, Kumar V, Faubion WA, Yarovinsky F, Hofker M, Wijmenga C, Kracht M, Franke L, Aguirre V, Weersma RK, Gluck N, van de Sluis B, Burstein E Gastroenterology 2014 Apr
    Regulation of NF-?B activity by competition between RelA acetylation and ubiquitination.
    Li H, Wittwer T, Weber A, Schneider H, Moreno R, Maine GN, Kracht M, Schmitz ML, Burstein E Oncogene 2011 Jun
    COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion.
    van de Sluis B, Mao X, Zhai Y, Groot AJ, Vermeulen JF, van der Wall E, van Diest PJ, Hofker MH, Wijmenga C, Klomp LW, Cho KR, Fearon ER, Vooijs M, Burstein E J. Clin. Invest. 2010 Jun 120 6 2119-30

    Honors & Awards

    • Member
      The American Society for Clinical Investigation (ASCI) (2012)
    • Helmsley Scholar
      Crohn’s and Colitis Foundation of America (2010)
    • AGA Research Scholar Award
      Foundation for Digestive Health and Nutrition (2003)
    • John S. Miller Award
      Outstanding Performance as a House Officer, UT Southwestern Medical School (1998)
    • Valedictorian
      Medical School of Cayetano Heredia University (1994)

    Professional Associations/Affiliations

    • American Society for Clinical Investigation (ASCI) (2012)
    • American Gastroenterological Association (AGA) (1999)