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Dr. Burstein received his medical degree from Cayetano Heredia University in Lima, Peru.  He completed his Internal Medicine residency training at UT Southwestern Medical School and a Gastroenterology fellowship at the University of Michigan Medical School.  Thereafter, he was also a research fellow at the Vaccine Research Center at the National Institutes of Health.  After completion of his training, he joined the Faculty at University of Michigan (2001-2008), and was later recruited to UT Southwestern, joining the Departments of Internal Medicine (Division of Digestive and Liver Diseases) and Molecular Biology. Dr. Burstein′s research interests include the molecular regulation of the inflammatory response, particularly in the intestinal tract, and ubiquitination events targeting the NF-kB transcription factor.  


Medical School
Cayetano Heredia Peruvian University (1994)
UT Southwestern Medical Center (1998), Internal Medicine
University of Michigan Hospitals & Health Centers (2001), Gastroenterology
Graduate School
University of Groningen (2013), Molecular Genetics

Specialty Areas

Clinical Interest

  • Celiac Disease
  • Crohn's Disease
  • Familial Adeomatous Polyposis (FAP)
  • Hereditary Non-Polyposis Colorectal Cancer
  • Inflammatory Bowel Disease (IBD)
  • Lynch Syndrome
  • MYH Polyposis Syndrome
  • Ulcerative Colitis
  • Research Interest

    • COMMD proteins
    • Genetics of inflammatory disorders
    • Inflammation, particularly in the intestinal tract


    Featured Publications LegendFeatured Publications

    Copper Metabolism Domain-containing 1 Represses Genes that Promote Inflammation and Protects Mice From Colitis and Colitis-associated Cancer.
    Li H, Chan L, Bartuzi P, Melton SD, Weber A, Ben-Shlomo S, Varol C, Raetz M, Mao X, Starokadomskyy P, van Sommeren S, Mokadem M, Schneider H, Weisberg R, Westra HJ, Esko T, Metspalu A, Kumar V, Faubion WA, Yarovinsky F, Hofker M, Wijmenga C, Kracht M, Franke L, Aguirre V, Weersma RK, Gluck N, van de Sluis B, Burstein E Gastroenterology 2014 Apr
    Regulation of NF-?B activity by competition between RelA acetylation and ubiquitination.
    Li H, Wittwer T, Weber A, Schneider H, Moreno R, Maine GN, Kracht M, Schmitz ML, Burstein E Oncogene 2011 Jun
    COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion.
    van de Sluis B, Mao X, Zhai Y, Groot AJ, Vermeulen JF, van der Wall E, van Diest PJ, Hofker MH, Wijmenga C, Klomp LW, Cho KR, Fearon ER, Vooijs M, Burstein E J. Clin. Invest. 2010 Jun 120 6 2119-30
    GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA.
    Mao X, Gluck N, Li D, Maine GN, Li H, Zaidi IW, Repaka A, Mayo MW, Burstein E Genes Dev. 2009 Apr 23 7 849-61

    Honors & Awards

    • Member
      The American Society for Clinical Investigation (ASCI) (2012)
    • Helmsley Scholar
      Crohn’s and Colitis Foundation of America (2010)
    • AGA Research Scholar Award
      Foundation for Digestive Health and Nutrition (2003)
    • John S. Miller Award
      Outstanding Performance as a House Officer, UT Southwestern Medical School (1998)
    • Valedictorian
      Medical School of Cayetano Heredia University (1994)