Dr. Repa’s research at UT Southwestern focuses on the effects of diet and drugs on nuclear receptor regulation of gene expression, and how these signaling pathways contribute to such diseases as atherosclerosis and Type II diabetes. Her research is aimed at understanding the molecular mechanisms by which nuclear orphan receptors regulate lipid and carbohydrate metabolism in the liver, intestine and pancreatic beta cell. The results of this research may provide clues to novel therapies for the treatment of these two very serious diseases.


Undergraduate University of Wisconsin-Madison (1979), Biochemistry
Graduate School University of Wisconsin-Madison (1990), Science
Graduate School University of Wisconsin-Madison (1996), Science

Research Interest

  • Bile acids, Cholesterol
  • Diabetes
  • LXR, FXR, PXR, beta-cell, islet
  • Nuclear hormone receptor
  • Transcription


Featured Publications LegendFeatured Publications

Honors & Awards

  • Everson Award for distinguished alumni
    presented by the Department of Biochemistry, University of Wisconsin-Madison (2002)