Dr. Repa’s research at UT Southwestern focuses on the effects of diet and drugs on nuclear receptor regulation of gene expression, and how these signaling pathways contribute to such diseases as atherosclerosis and Type II diabetes. Her research is aimed at understanding the molecular mechanisms by which nuclear orphan receptors regulate lipid and carbohydrate metabolism in the liver, intestine and pancreatic beta cell. The results of this research may provide clues to novel therapies for the treatment of these two very serious diseases.
|Undergraduate||University of Wisconsin-Madison (1979), Biochemistry|
|Graduate School||University of Wisconsin-Madison (1990), Science|
|Graduate School||University of Wisconsin-Madison (1996), Science|
- Bile acids, Cholesterol
- LXR, FXR, PXR, beta-cell, islet
- Nuclear hormone receptor
Kannenberg F, Gorzelniak K, Jager K, Fobker M, Rust S, Repa J, Roth M, Bjorkhem I, Walter M J. Biol. Chem. 2013 Nov
Mani BK, Chuang JC, Kjalarsdottir L, Sakata I, Walker AK, Kuperman A, Osborne-Lawrence S, Repa JJ, Zigman JM Endocrinology 2013 Nov
Jones RD, Taylor AM, Tong EY, Repa JJ Drug Metab. Dispos. 2013 Jan 41 1 40-9
Taylor AM, Liu B, Mari Y, Liu B, Repa JJ J. Lipid Res. 2012 Nov 53 11 2331-42
Chuang JC, Sakata I, Kohno D, Perello M, Osborne-Lawrence S, Repa JJ, Zigman JM Molecular endocrinology (Baltimore, Md.) 2011 Jun 1600-11
Ogihara T, Chuang JC, Vestermark GL, Garmey JC, Ketchum RJ, Huang X, Brayman KL, Thorner MO, Repa JJ, Mirmira RG, Evans-Molina C J. Biol. Chem. 2010 Feb 285 8 5392-404
Research resource: nuclear hormone receptor expression in the endocrine pancreas.
Chuang JC, Cha JY, Garmey JC, Mirmira RG, Repa JJ Mol Endocrinol October 2008 22(10) 2353-63
Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse.
Repa, J. J., H. Li, T. C. Frank-Cannon, M. A. Valasek, S. D. Turldy, M. G. Tansey, and J. M. Dietschy J. Neurosci. December 2007 27 14470-14480
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.
Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P Proc Natl Acad Sci U S A January 2001 98(2) 507-12
Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding.
Repa JJ, Lund EG, Horton JD, Leitersdorf E, Russell DW, Dietschy JM, Turley SD J Biol Chem December 2000 275(50) 39685-92.
Honors & Awards
- Everson Award for distinguished alumni
presented by the Department of Biochemistry, University of Wisconsin-Madison (2002)