Dr. Chun-Li Zhang received his Ph.D. in Genetics and Development from UT Southwestern Medical Center, where he worked on transcriptional control of muscle development and heart disease. Upon graduation in 2003, he conducted postdoctoral research as a HHMI Fellow of the Life Sciences Research Foundation in Dr. Ronald Evans’ laboratory at the Salk Institute, La Jolla, California. In collaboration with Dr. Fred Gage at the same institute, Dr. Zhang worked on adult neural stem cells and neurogenesis. In 2008, he joined the faculty as an Assistant Professor at UT Southwestern. The major focus of his laboratory is on molecular mechanisms controlling neural stem cells, adult neurogenesis, regeneration of the central nervous system, and cellular reprogramming.


Graduate School
Wuhan University - China , Molecular & Cell Biology
Graduate School
University of Texas Southwestern Med Ctr Dallas (2002), Genetics

Research Interest

  • Epigenetics
  • Neural Stem Cell
  • Regeneration
  • Reprogramming
  • Tumorigenesis


Featured Publications LegendFeatured Publications

Structural basis for corepressor assembly by the orphan nuclear receptor TLX.
Zhi X, Zhou XE, He Y, Searose-Xu K, Zhang CL, Tsai CC, Melcher K, Xu HE Genes Dev. 2015 Feb 29 4 440-50
Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor.
Long C, Grueter CE, Song K, Qin S, Qi X, Kong YM, Shelton JM, Richardson JA, Zhang CL, Bassel-Duby R, Olson EN Proc. Natl. Acad. Sci. U.S.A. 2014 Jul
TLX: A master regulator for neural stem cell maintenance and neurogenesis.
Islam MM, Zhang CL Biochim. Biophys. Acta 2014 Jun

Honors & Awards

  • The Decherd Foundation Award
  • 2014’s Big Advances in Science (2014)
  • The Ellison Medical Foundation: New Scholar in Aging
  • The Whitehall Foundation: Research Award
  • Winner of NuGEN Innovation Grant Challenge
  • NIH: Director's New Innovator Award
  • Scientist Development Award-American Heart Association
  • W.W.Caruth, Jr. Scholar in Biomedical Research-UT Southwestern
  • HHMI Fellow of the Life Sciences Research Foundation
  • Dean’s Discretionary Award, UT Southwestern Medical Center at Dallas

Professional Associations/Affiliations

  • Center for Regenerative Science and Medicine (2014)
  • International Society for Stem Cell Research (2008)
  • Society for Neuroscience