Cornell University (1997), Biology
Graduate School
University of Texas Southwestern Med Ctr Dallas (2002), Cell Biology

Research Interest

  • Breast Cancer
  • Cell motility and invasion
  • Epithelial-to Mesenchymal Transition
  • Metastasis
  • Tumor microenvironment


Featured Publications LegendFeatured Publications

Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.
Dbouk HA, Weil LM, Perera GK, Dellinger MT, Pearson G, Brekken RA, Cobb MH Proc. Natl. Acad. Sci. U.S.A. 2014 Nov 111 45 15999-6004
PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture.
Pearson GW, Hunter T Breast Cancer Res. 2009 11 3
Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals.
Pearson GW, Earnest S, Cobb MH Mol. Cell. Biol. 2006 Apr 26 8 3039-47
Cell condition-dependent regulation of ERK5 by cAMP.
Pearson GW, Cobb MH J. Biol. Chem. 2002 Dec 277 50 48094-8
ERK5 and ERK2 cooperate to regulate NF-kappaB and cell transformation.
Pearson G, English JM, White MA, Cobb MH J. Biol. Chem. 2001 Mar 276 11
Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation.
Pearson G, Bumeister R, Henry DO, Cobb MH, White MA J. Biol. Chem. 2000 Dec 275 48