Featured Publications
Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity
Zeng, W., Sun, L., Jiang, X., Chen, X., Hou, F., Adhikari, A., Xu, M., and Chen, Z.J. Cell April 2010 141 315-330
A ubiquitin replacement strategy reveals distinct mechanisms of IKK activation by TNFα and IL-1β
Xu, M., Skaug, B., Zeng, W., and Chen, Z.J. Molecular Cell October 2009 36 315-325
Key role of Ubc5 and K63 polyubiquitination in viral activation of IRF3
Zeng, W., Xu, M., Liu, S., Sun, L., Chen, Z.J Molecular Cell October 2009 36 302-314
Direct activation of protein kinases by unanchored polyubiquitin chains
Xia, Z.P., Sun, L., Chen, X., Pineda, G., Jiang, X., Adhikari, A., Zeng, W., and Chen, Z.J Nature August 2009 461 114-119
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway
Chiu, Y.H., Macmillan, J.B., and Chen, Z.J Cell August 2009 138 576-591
The specific and essential role of MAVS in antiviral innate immune responses
Sun, Q., Sun, L., Liu, H-H., Chen, X., Seth, R.B., Forman, J. and Chen, Z.J Immunity May 2006 24 633-642
Activation of IKK by TNFα requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
Ea, C-K., Deng, L., Xia, Z-P., Pineda, G., and Chen, Z.J Molecular Cell April 2006 22 245-257
Identification and characterization of MAVS: a mitochondrial antiviral signaling protein that activates NF-κB and IRF3.
Seth, R.B., Sun, L., Ea, C., and Chen, Z.J. Cell 2005 122 669-682
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
Wang, C., Deng, L., Hong, M. Akkaraju, G.R., Inoue, J-i., and Chen, Z Nature July 2001 412 346-351
Activation of the IkB kinase complex requires a dimeric ubiquitin conjugating enzyme complex and the formation of a unique polyubiquitin chain
Deng, L., Wang, C., Spencer, E., Yang, L., Braun, A., You, J., Slaughter, C., Pickart, C., and Chen, Z Cell October 2000 103 351-361
