Joseph Crossno, M.D., Ph.D. Associate Professor School Medical School Department Internal Medicine You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Joseph Crossno, M.D., Ph.D. is an Associate Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Pulmonary and Critical Care Medicine. His clinical interests include pulmonary vascular development and repair, end-stage lung disease, cardiopulmonary support, and lung transplantation. Dr. Crossno holds a bachelor's degree in microbiology and immunology from the University of Tennessee in Knoxville. He earned his medical degree and a doctoral degree in biochemistry at the University of Tennessee Health Science Center in Memphis. He then completed internal medicine residency training at Virginia Commonwealth University Medical Center in Richmond and gained advanced subspecialty training in pulmonary and critical care medicine through a fellowship at the University of Colorado Health Sciences Center in Denver. Certified by the American Board of Internal Medicine in internal medicine, pulmonary medicine, and critical care medicine, Dr. Crossno joined the UT Southwestern faculty in 2024. He previously served as Medical Director of Lung Transplantation at INTEGRIS Health Baptist Medical Center in Oklahoma City. Dr. Crossno is a Fellow of the American College of Chest Physicians, the American Thoracic Society, the International Society for Heart and Lung Transplantation, and the American Society of Transplantation. Dr. Crossno's research interests include lung repair and regeneration. His research has been published in peer-reviewed academic journals and he has contributed to books. In addition, he has presented his findings at scientific conferences. In his free time, Dr. Crossno enjoys travel, golf, spending time with his family, watching college sports, and cooking, especially congruent food and wine pairing. Education Medical School University of Tennessee Health Science Center (1996) Residency Virginia Commonwealth University Health System (1999), Internal Medicine Fellowship University of Colorado School of Medicine (2002), Pulmonary & Critical Care Medicine Research Interest Lung repair and regeneration Publications Featured Publications Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension. Chakraborty A, Nathan A, Orcholski M, Agarwal S, Shamskhou EA, Auer N, Mitra A, Guardado ES, Swaminathan G, Condon DF, Yu J, McCarra M, Juul NH, Mallory A, Guzman-Hernandez RA, Yuan K, Rojas V, Crossno JT, Yung LM, Yu PB, Spencer T, Winn RA, Frump A, Karoor V, Lahm T, Hedlin H, Fineman JR, Lafyatis R, Knutsen CNF, Alvira CM, Cornfield DN, de Jesus Perez VA, Eur Respir J 2023 Jun 61 6 Liver Transplantation for Decompensated Cirrhosis Secondary to Telomerase Reverse Transcriptase Mutation. Kolb JM, Conzen K, Wachs M, Crossno J, McMahon B, Abidi MZ, Pomfret EA, Kriss M, Hepatology 2020 Jul 72 1 356-358 Successful COVID-19 rescue therapy by extra-corporeal membrane oxygenation (ECMO) for respiratory failure: a case report. Firstenberg MS, Stahel PF, Hanna J, Kotaru C, Crossno J, Forrester J, Patient Saf Surg 2020 14 20 Airway epithelial cell PPARĪ³ modulates cigarette smoke-induced chemokine expression and emphysema susceptibility in mice. Solleti SK, Simon DM, Srisuma S, Arikan MC, Bhattacharya S, Rangasamy T, Bijli KM, Rahman A, Crossno JT, Shapiro SD, Mariani TJ, Am J Physiol Lung Cell Mol Physiol 2015 Aug 309 3 L293-304 Obesity-related pulmonary arterial hypertension in rats correlates with increased circulating inflammatory cytokines and lipids and with oxidant damage in the arterial wall but not with hypoxia. Irwin DC, Garat CV, Crossno JT, MacLean PS, Sullivan TM, Erickson PF, Jackman MR, Harral JW, Reusch JE, Klemm DJ, Pulm Circ 2014 Dec 4 4 638-53 Late-onset cytomegalovirus (CMV) in lung transplant recipients: can CMV serostatus guide the duration of prophylaxis? Schoeppler KE, Lyu DM, Grazia TJ, Crossno JT, Vandervest KM, Zamora MR, Am J Transplant 2013 Feb 13 2 376-82 A potential role for reactive oxygen species and the HIF-1alpha-VEGF pathway in hypoxia-induced pulmonary vascular leak. Irwin DC, McCord JM, Nozik-Grayck E, Beckly G, Foreman B, Sullivan T, White M, T Crossno J, Bailey D, Flores SC, Majka S, Klemm D, van Patot MC, Free Radic Biol Med 2009 Jul 47 1 55-61 Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell-derived factor-1alpha. Nemenoff RA, Simpson PA, Furgeson SB, Kaplan-Albuquerque N, Crossno J, Garl PJ, Cooper J, Weiser-Evans MC, Circ Res 2008 May 102 9 1036-45 Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling. Crossno JT, Garat CV, Reusch JE, Morris KG, Dempsey EC, McMurtry IF, Stenmark KR, Klemm DJ, Am J Physiol Lung Cell Mol Physiol 2007 Apr 292 4 L885-97 Mice deficient in galectin-1 exhibit attenuated physiological responses to chronic hypoxia-induced pulmonary hypertension. Case D, Irwin D, Ivester C, Harral J, Morris K, Imamura M, Roedersheimer M, Patterson A, Carr M, Hagen M, Saavedra M, Crossno J, Young KA, Dempsey EC, Poirier F, West J, Majka S, Am J Physiol Lung Cell Mol Physiol 2007 Jan 292 1 L154-64 Results 1-10 of 19 1 2 Next Last Books Featured Books CD9 Cluster Workshop Report: Cell surface binding and functional analysis. In Leukocyte Typing V White Cell Differentiation Antigens: Volume II Jennings, L.K., Crossno, Jr., J.T., and White, M.M (1995). Oxford, Great Britain, Oxford University Press Procedures in Pulmonary Medicine. In Current Diagnosis and Treatment in Pulmonary Medicine Crossno, Jr., J.T. (2003). New York, NY, McGraw-Hill Medical Publishing CD9 Structure and Function. In Platelets, Thrombosis and the Vessel Wall: Advances in Vascular Biology Jennings, L.K., Crossno, Jr., J.T., and White, M.M. (1997). Gordon and Breach, Inc. Honors & Awards American Thoracic Society Scientific Breakthrough of the Year AwardStem Cells and Regenerative Medicine, New Orleans, Louisiana (2010) Professional Associations/Affiliations American College of Chest Physicians (1999) American Society of Transplantation (2009) American Thoracic Society (1999) International Society of Heart and Lung Transplantation (2006)
