Featured Publications
Structural characterization of a unique interface between carbohydrate response element binding protein (ChREBP) and 14-3-3ß
Ge Q, Huang N, Wynn RM, Li Y, Du X, Miller B, Zhang H, Uyeda K J. Biol. Chem. 2012 Oct
Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.
Huang N, Chelliah Y, Shan Y, Taylor CA, Yoo SH, Partch C, Green CB, Zhang H, Takahashi JS Science 2012 Jul 337 6091 189-94
Translin:TRAX complex (C3PO), a novel ribonuclease for the degradation of small RNAs.
Zhang, H. and Liu, Q. The Enzymes, 32, Part B. RNA endonuclease in RNAi and microRNA andmetabolism and their partners 2012 69-82
Structure of C3PO and mechanism of human RISC activation.
Ye X, Huang N, Liu Y, Paroo Z, Huerta C, Li P, Chen S, Liu Q, Zhang H Nat. Struct. Mol. Biol. 2011 Jun 18 6 650-7
Complexes of bacterial nicotinate mononucleotide adenylyltransferase with inhibitors: implication for structure-based drug design and improvement.
Huang N, Kolhatkar R, Eyobo Y, Sorci L, Rodionova I, Osterman AL, Mackerell AD, Zhang H J. Med. Chem. 2010 Jul 53 14 5229-39
Structure and function of an ADP-ribose-dependent transcriptional regulator of NAD metabolism.
Huang N, De Ingeniis J, Galeazzi L, Mancini C, Korostelev YD, Rakhmaninova AB, Gelfand MS, Rodionov DA, Raffaelli N, Zhang H Structure 2009 Jul 17 7 939-51
Structure and Mechanism of a Eukaryotic FMN Adenylyltransferase
Huerta, C., Borek, D., Machius, M., Grishin, N. V. and Zhang, H. J. Mol. Biol. 2009 389 388-400
Targeting NAD biosynthesis in bacterial pathogens. Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD.
Sorci, L., Pan, Y., Eyobo, Y., Rodionova, I., Huang, N., Kurnasov, O., Zhong, S., MacKerell, Jr., A. D., Zhang, H. and Osterman, A. L. Chem. & Biol. 2009 16 849-861
Protein prenyltransferases
Zhang, H. Handbook of Metalloproteins 2004 3 p37-48
Crystal structure of human riboflavin kinase reveals a b barrel fold and a novel active site arch.
Karthikeyan, S., Zhou, Q., Mseeh, F., Grishin, N. V., Osterman, A. L. and Zhang, H. Structure 2003 11 265-273
