Yoshiharu Muto, M.D., Ph.D. - Faculty Profile

Biography

Yoshiharu Muto, M.D., Ph.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Nephrology.

Originally from Fukuoka, Japan, Dr. Muto earned his medical degree and doctoral degree in philosophy (medical science) from Kyushu University. He received internal medicine residency training and completed fellowship training in nephrology at Iizuka Hospital. He acquired postdoctoral research training in nephrology at Washington University in St. Louis.

Dr. Muto joined the UT Southwestern Faculty in 2024. Prior to joining UT Southwestern, he served as an Instructor at Washington University.

Dr. Muto has been investigating the epigenetic mechanism underlying the kidney diseases, especially focusing on acute kidney injury and its transition to chronic kidney disease, as well as polycystic kidney disease. His focus is on how cellular metabolic deregulation can modulate epigenome in kidney diseases, to identify novel therapeutic targets. He has combined mouse genetics with single cell analysis and other cutting-edge genomic techniques to study kidney diseases.

Dr. Muto's interests outside of medical research include spending time with his family, cooking, reading, and the great outdoors.

Research Interest

Epigenetic alteration in kidney diseases
Metabolic deregulation in kidney diseases
Single cell analysis

Publications

Epigenetic reprogramming driving successful and failed repair in acute kidney injury: Muto Y, Dixon EE, Ledru N, Kirita Y, Wu H, Humphreys BD Science advances 2024 Aug 10
Injury-induced Foxm1 expression in the mouse kidney drives epithelial proliferation by a cyclin F-dependent mechanism: Noonan ML, Muto Y, Yoshimura Y, Leckie-Harre A, Wu H, Kalinichenko VV, Humphreys BD, Chang-Panesso M JCI insight 2024 Jun 9
Multi-omics profiling of mouse polycystic kidney disease progression at a single cell resolution: Muto Y, Yoshimura Y, Wu H, Chang-Panesso M, Ledru N, Woodward OM, Outeda P, Cheng T, Mahjoub MR, Watnick TJ, Humphreys BD bioRxiv : the preprint server for biology 2024 May
TNIK depletion induces inflammation and apoptosis in injured renal proximal tubule epithelial cells: Bradford ST, Wu H, Kirita Y, Chen C, Malvin NP, Yoshimura Y, Muto Y, Humphreys BD American Journal of Physiology - Renal Physiology 2024 May 326 F827-F838
Predicting proximal tubule failed repair drivers through regularized regression analysis of single cell multiomic sequencing: Ledru N, Wilson PC, Muto Y, Yoshimura Y, Wu H, Li D, Asthana A, Tullius SG, Waikar SS, Orlando G, Humphreys BD Nature communications 2024 Feb 15
Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease: Wilson PC, Verma A, Yoshimura Y, Muto Y, Li H, Malvin NP, Dixon EE, Humphreys BD Genome biology 2024 Jan 25
Leveraging multimodal chromatin profiling to identify a new potential driver of diabetic kidney disease: Muto Y, Humphreys BD Kidney international 2024 Jan 105 25-27
Elucidating the Proximal Tubule HNF4A Gene Regulatory Network in Human Kidney Organoids: Yoshimura Y, Muto Y, Omachi K, Miner JH, Humphreys BD Journal of the American Society of Nephrology 2023 Oct 34 1672-1686
A single-cell multiomic analysis of kidney organoid differentiation: Yoshimura Y, Muto Y, Ledru N, Wu H, Omachi K, Miner JH, Humphreys BD Proceedings of the National Academy of Sciences of the United States of America 2023 May 120
Tubular Epithelial Cell HMGB1 Promotes AKI-CKD Transition by Sensitizing Cycling Tubular Cells to Oxidative Stress: A Rationale for Targeting HMGB1 during AKI Recovery: Zhao ZB, Marschner JA, Iwakura T, Li C, Motrapu M, Kuang M, Popper B, Linkermann A, Klocke J, Enghard P, Muto Y, Humphreys BD, Harris HE, Romagnani P, Anders HJ Journal of the American Society of Nephrology 2023 Mar 34 394-411

Honors & Awards

PKD-RRC Pilot and Feasibility Grant
(2024)
Carl W. Gottschalk Research Scholar Grant
(2023)

Professional Associations/Affiliations

American Society of Nephrology