Nikolaos “Nikos” Louros, Ph.D.

• Functional amyloids
• Heterotypic amyloid interactions
• Molecular Biophysics / Computational biology / Structural biology
• Neurodegenerative diseases
• Protein aggregation

Featured Publications

Local structural preferences in shaping tau amyloid polymorphism.

Louros N, Wilkinson M, Tsaka G, Ramakers M, Morelli C, Garcia T, Gallardo R, D'Haeyer S, Goossens V, Audenaert D, Thal DR, Mackenzie IR, Rademakers R, Ranson NA, Radford SE, Rousseau F, Schymkowitz J, Nat Commun 2024 Feb 15 1 1028

Mechanisms and pathology of protein misfolding and aggregation.

Louros N, Schymkowitz J, Rousseau F, Nat Rev Mol Cell Biol 2023 Dec 24 12 912-933

LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons.

Libé-Philippot B, Lejeune A, Wierda K, Louros N, Erkol E, Vlaeminck I, Beckers S, Gaspariunaite V, Bilheu A, Konstantoulea K, Nyitrai H, De Vleeschouwer M, Vennekens KM, Vidal N, Bird TW, Soto DC, Jaspers T, Dewilde M, Dennis MY, Rousseau F, Comoletti D, Schymkowitz J, Theys T, de Wit J, Vanderhaeghen P, Cell 2023 Dec 186 26 5766-5783.e25

Heterotypic Amyloid β interactions facilitate amyloid assembly and modify amyloid structure.

Konstantoulea K, Guerreiro P, Ramakers M, Louros N, Aubrey LD, Houben B, Michiels E, De Vleeschouwer M, Lampi Y, Ribeiro LF, de Wit J, Xue WF, Schymkowitz J, Rousseau F, EMBO J 2022 Dec 41 2 e108591

Medin co-aggregates with vascular amyloid-β in Alzheimer's disease.

Wagner J, Degenhardt K, Veit M, Louros N, Konstantoulea K, Skodras A, Wild K, Liu P, Obermüller U, Bansal V, Dalmia A, Häsler LM, Lambert M, De Vleeschouwer M, Davies HA, Madine J, Kronenberg-Versteeg D, Feederle R, Del Turco D, Nilsson KPR, Lashley T, Deller T, Gearing M, Walker LC, Heutink P, Rousseau F, Schymkowitz J, Jucker M, Neher JJ, Nature 2022 Dec 612 7938 123-131

Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers.

Louros N, Ramakers M, Michiels E, Konstantoulea K, Morelli C, Garcia T, Moonen N, D'Haeyer S, Goossens V, Thal DR, Audenaert D, Rousseau F, Schymkowitz J, Nat Commun 2022 Mar 13 1 1351

Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities.

Louros N, Orlando G, De Vleeschouwer M, Rousseau F, Schymkowitz J, Nat Commun 2020 Jul 11 1 3314

N-glycosylation as a eukaryotic protective mechanism against protein aggregation.

Duran-Romaña R, Houben B, De Vleeschouwer M, Louros N, Wilson MP, Matthijs G, Schymkowitz J, Rousseau F, Sci Adv 2024 Feb 10 5 eadk8173

CORDAX web server: An online platform for the prediction and 3D visualization of aggregation motifs in protein sequences.

Louros N, Rousseau F, Schymkowitz J, Bioinformatics 2024 btae279 https://doi.org/10.1093/bioinformatics/btae279

Author Correction: Reverse engineering synthetic antiviral amyloids.

Michiels E, Roose K, Gallardo R, Khodaparast L, Khodaparast L, van der Kant R, Siemons M, Houben B, Ramakers M, Wilkinson H, Guerreiro P, Louros N, Kaptein SJF, Ibañez LI, Smet A, Baatsen P, Liu S, Vorberg I, Bormans G, Neyts J, Saelens X, Rousseau F, Schymkowitz J, Nat Commun 2023 Jun 14 1 3492

 Featured Books

Exploring amyloidogenicity of clusterin: a structural and bioinformatics analysis. In Adv. Exp. Med. and Biol.

Paraskevi L Tsiolaki, Katerina C Nastou, Nikolaos Louros, Stavros J Hamodrakas, Vassiliki A Iconomidou (2017). Springer International Publishing

• "Nikos Oikonomakos" Award
  (2014)
• Endowed Scholar Award
  (2024-2029)
• HSCBB15 Award
  Hellenic Society for Computational Biology & Bioinformatics Award (2015)
• HSCBB16 Award
  Hellenic Society for Computational Biology & Bioinformatics Award (2016)
• International Society of Amyloidosis (ISA) Presidential Award
  2024
• Stichting Alzheimer's Onderzoek (SAO) Young investigator award
  (2021-2023)
• Stichting Alzheimer's Onderzoek (SAO) Young investigator award
  (2023-2024)