Evan Noch, M.D., Ph.D.

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Dr. Evan Noch is an Assistant Professor of Neurology and the Director of Physician-Scientist Development in the Department of Neurology at the University of Texas Southwestern Medical Center.  Dr. Noch earned his MD and PhD degrees from Temple University, where he completed his graduate studies in Biomedical Neuroscience with Kamel Khalili on the role of cellular and viral oncogenes in oxygen and glucose metabolism in malignant brain tumors.  

He went on to complete his residency in Neurology in the research track at Weill Cornell Medicine and fellowship in Neuro-oncology at Memorial Sloan Kettering Cancer Center.  He performed his post-doctoral studies in the lab of Lewis Cantley at Weill Cornell Medicine, where he studied nutrient metabolism in glioma. In his post-doctoral work, he demonstrated that insulin feedback is a targetable mechanism of resistance to PI3K inhibition in glioblastoma.  In separate work, he demonstrated that cysteine induces mitochondrial toxicity in glioma cells and in orthotopic glioblastoma mouse models. 

In his lab, Dr. Noch studies glioblastoma metabolism, with a focus on synergistic drug and dietary therapies targeting glucose utilization and redox pathways.  He received a K08 career development award from the National Institute of Neurological Disorders and Stroke for his work on targeting cysteine susceptibility in glioma.  He is also the recipient of the Society for Neuro-oncology/Prime Oncology Young Investigator Award and the Excellence in Medical Education Award from Weill Cornell Medicine.

Dr. Noch serves on the Board of Directors of the American Physician Scientists Association, the leading organization advocating for physician-scientist trainees.

Medical School

Lewis Katz School of Medicine at Temple University (2013)

Internship

New York Presbyterian Hospital - Weill Cornell Medical Center (2014), Internal Medicine

Residency

New York Presbyterian Hospital - Weill Cornell Medical Center (2017), Neurology

Fellowship

Memorial Sloan Kettering Cancer Institute (2019), Neuro-oncology

• Improving disability in patients with radiation encephalopathy
• Nutrient metabolism in glioma
• Reductive stress in glioma
• Understanding risk factor perceptions in patients with brain tumors

Featured Publications

Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production.

Noch EK, Palma L, Yim I, Bullen N, Barnett D, Walsh A, Bhinder B, Benedetti E, Krumsiek J, Gurvitch J, Khwaja S, Atlas D, Elemento O, Cantley LC, Proc Natl Acad Sci U S A 2024 Feb 121 8 e2317343121

Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma.

Noch EK, Palma LN, Yim I, Bullen N, Qiu Y, Ravichandran H, Kim J, Rendeiro A, Davis MB, Elemento O, Pisapia DJ, Zhai K, LeKaye HC, Koutcher JA, Wen PY, Ligon KL, Cantley LC, Neuro Oncol 2023 Dec 25 12 2165-2176

Impact of COVID-19 Pandemic on Physician-Scientist Trainees to Faculty One Year into the Pandemic.

Obradovic A, Toubat O, Chen NW, Siebert A, Jansen C, Christophers B, Leveille E, Noch E, Kwan JM, Res Sq 2023 Nov

Metabolic partitioning in the brain and its hijacking by glioblastoma.

de Ruiter Swain J, Michalopoulou E, Noch EK, Lukey MJ, Van Aelst L, Genes Dev 2023 Aug 37 15-16 681-702

Qualitative feasibility study of the mobile app Destroke for clinical stroke monitoring based on the NIH stroke scale.

Noch EK, Pham D, Kitago T, Wuennemann M, Wortman-Jutt S, Falo MC, Heliyon 2023 Aug 9 8 e18393

The Impact of COVID-19 on Physician-Scientist Trainees and Faculty in the United States: A National Survey.

Kwan JM, Noch E, Qiu Y, Toubat O, Christophers B, Azzopardi S, Gilmer G, Wiedmeier JE, Daye D, Acad Med 2022 Oct 97 10 1536-1545

A case series of extraneural metastatic glioblastoma at Memorial Sloan Kettering Cancer Center.

Noch EK, Sait SF, Farooq S, Trippett TM, Miller AM, Neurooncol Pract 2021 Jun 8 3 325-336

Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain.

Noch EK, Yim I, Milner TA, Cantley LC, J Comp Neurol 2021 Feb 529 2 434-449

The Death of Actively Dying.

Noch EK, J Palliat Med 2020 Sep 23 9 1149

Challenges in the Treatment of Glioblastoma: Multisystem Mechanisms of Therapeutic Resistance.

Noch EK, Ramakrishna R, Magge R, World Neurosurg 2018 Aug 116 505-517

• Excellence in Medical Education Award, Weill Cornell Medicine
  (2022)
• Finalist, American Academy of Neurology Brainstorming Competition for Destroke, Annual Meeting, Philadelphia, PA
  (2019)
• Scholar-in-training Award, AACR Annual Meeting, Atlanta, GA
  (2019)
• Society for Neuro-oncology/Prime Oncology Young Investigator Award, Atlanta, GA
  (2019)
• Trainee Travel Award, Central Society for Clinical and Translational Research Annual Meeting, Chicago, IL
  (2019)
• Winner, Most Impactful Hack for DESTROKE, Cornell Health Hackathon, New York, NY
  (2019)
• Selected Trainee, AACR Molecular Biology in Clinical Oncology Workshop, Snowmass, CO
  (2018)
• Resident Research Award, Weill Cornell Medicine Department of Neurology
  (2017)

• American Academy of Neurology (2013)
• American Physician Scientists Association (APSA) (2013)
• Destroke, Inc. (2020)
• Society for Neuro-oncology (2017)