Pranavkumar Shivakumar, Ph.D. Associate Professor School Medical School Department Pediatrics Biography Dr. Pranav Shivakumar, Ph.D., is an Associate Professor in the Department of Pediatrics at UT Southwestern Medical Center and Director of the Biliary Atresia Research and Cure Center in the Division of Pediatric Gastroenterology, Hepatology, and Nutrition. He earned his diploma and bachelor’s degree in pharmaceutical sciences from Karnataka University, Dharwad, India, and his master’s and Ph.D. in technology from the University Institute of Chemical Technology, University of Mumbai, India, where he earned junior and senior scholarships from the government of India. Dr. Shivakumar completed his post-doctoral fellowship and training in pediatric hepatology with a specific focus on biliary atresia at Cincinnati Children’s Hospital Medical Center. He then joined the Division of Gastroenterology, Hepatology, and Nutrition, and the Department of Pediatrics at the University of Cincinnati College of Medicine and established research programs to investigate mechanisms of biliary atresia pathogenesis. Dr. Shivakumar’s research focuses on understanding how innate and adaptive immune systems independently, and in concert, orchestrate to induce bile duct epithelial injury, inflammation, and atresia (complete absence of duct lumen). The goal of his research is to better understand the mechanisms of biliary disease and develop novel therapeutics to promote long-term native liver survival in infants with biliary atresia. To understand the early processes of epithelial injury, duct inflammation, and blockade, his laboratory has developed neonatal mouse models of biliary atresia and liver fibrosis induced by virus and toxins as well as organoids from mouse and patient liver tissue. Dr. Shivakumar is dedicated to promoting scientific training and education. He has mentored a large number of post-doctoral and clinical fellows, research personnel, and undergraduate and medical students who have successfully established their careers in medicine and other fields. Dr. Shivamkumar continues to work with medical students and gastrointestinal and hepatology fellows to further biliary atresia research and education. Research Interest Biliary atresia Cholangiopathies Complement biology Inflammation in the liver: Innate and adaptive immunology Neonatal Cholestasis Organoid technology Toxins in bile duct epithelial injury Publications Featured Publications HIF-1alpha-pathway activation in cholangiocytes of patients with biliary atresia: An immunohistochemical/molecular exploratory study. Quelhas P, Breton MC, Oliveira RC, Cipriano MA, Teixeira P, Cerski CT, Shivakumar P, Vieira SMG, Kieling CO, Verde I, Santos JLD, J Pediatr Surg 2023 Mar 58 3 587-594 Editorial: Infants with cholestasis. Uchida H, Tiao GM, Shivakumar P, Wong KKY, Asai A, Amano H, Front Pediatr 2023 11 1175231 Serum Proteomics Uncovers Biomarkers of Clinical Portal Hypertension in Children With Biliary Atresia. Osborn J, Mourya R, Thanekar U, Su W, Fei L, Shivakumar P, Bezerra JA, Hepatol Commun 2022 May 6 5 995-1004 Maternal regulation of biliary disease in neonates via gut microbial metabolites. Jee JJ, Yang L, Shivakumar P, Xu PP, Mourya R, Thanekar U, Yu P, Zhu Y, Pan Y, Wang H, Duan X, Ye Y, Wang B, Jin Z, Liu Y, Cao Z, Watanabe-Chailland M, Romick-Rosendale LE, Wagner M, Fei L, Luo Z, Ollberding NJ, Tang ST, Bezerra JA, Nat Commun 2022 Jan 13 1 18 Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia. Amarachintha SP, Mourya R, Ayabe H, Yang L, Luo Z, Li X, Thanekar U, Shivakumar P, Bezerra JA, Hepatology 2022 Jan 75 1 89-103 Recent developments in etiology and disease modeling of biliary atresia: a narrative review. Malik A, Thanekar U, Mourya R, Shivakumar P, Dig Med Res 2020 Dec 3 Regulation of bile duct epithelial injury by hepatic CD71+ erythroid cells. Yang L, Shivakumar P, Kinder J, Way SS, Donnelly B, Mourya R, Luo Z, Bezerra JA, JCI Insight 2020 Jun 5 11 "Complimenting the Complement": Mechanistic Insights and Opportunities for Therapeutics in Hepatocellular Carcinoma. Malik A, Thanekar U, Amarachintha S, Mourya R, Nalluri S, Bondoc A, Shivakumar P, Front Oncol 2020 10 627701 Gene Expression Signatures Associated With Survival Times of Pediatric Patients With Biliary Atresia Identify Potential Therapeutic Agents. Luo Z, Shivakumar P, Mourya R, Gutta S, Bezerra JA, Gastroenterology 2019 Oct 157 4 1138-1152.e14 Single cell RNA sequencing reveals regional heterogeneity of hepatobiliary innate lymphoid cells in a tissue-enriched fashion. Peters AL, Luo Z, Li J, Mourya R, Wang Y, Dexheimer P, Shivakumar P, Aronow B, Bezerra JA, PLoS One 2019 14 4 e0215481 Results 1-10 of 35 1 2 3 4 Next Last Honors & Awards Associate Editor, Frontiers in Pediatrics: Gastroenterology and Hepatology (2023) Fellow, The Royal Society of Medicine (2022) Associate Editor, Frontiers in Immunology (2021) Elected Fellow, American Association for the Study of Liver Diseases (2020) Elected Member, Society for Pediatric Research (2014) Elected Member, Sigma Xi, The Scientific Research Society (2009) FASEB Award, Snowmass Village, CO (2009) Key Resource Person, Symposium on Drug Design and Discovery, India (2008) Invited Speaker, University of Cincinnati College of Medicine, Cincinnati, OH (2007) Invited Speaker, International Symposium on Drug Discovery and Process Research (2006) Travel Award, NIH-NIDDK, Bethesda, MD (2006) Best Poster Award, DDRDC Scientific Retreat and External Advisory Board Meeting (2005) Travel Award, American Association for the Study of Liver Diseases, Boston, MA (2004) Travel Award, Mead Johnson Nutritionals (2004) Travel Award, American Association for the Study of Liver Diseases, Boston, MA (2003) Travel Award, Pediatric Academic Society, Seattle, WA (2003) Govt. of India UGC Senior Research Fellowship Award (1998) Academic Achievement Award, Indian Drug Manufacturers' Association (1996) Gold Medal, Bachelor's in Pharmacy, KLE University, Belgaum,India (1995) Govt. of India UGC Junior Research Fellowship Award (1995) Gold Medal, Diplomate in Pharmacy, KLE University, Belgaum, India (1990) Professional Associations/Affiliations American Association for the Study of Liver Diseases (2004) American Association of Pharmaceutical Scientists (2010) American Chemical Society (2014) American Gastroenterological Association (2012) American Society for Microbiology (2014) Indian Pharmaceutical Association (2002) International Complement Society (2008) North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (2012) Sigma Xi (2022) Society for Pediatric Research (2012)
