Featured Publications
A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma
Sivanand S, Peña-Llopis S, Zhao H, Kucejova B, Spence P, Pavia-Jimenez A, Yamasaki T, McBride DJ, Gillen J, Wolff NC, Morlock L, Lotan Y, Raj GV, Sagalowsky A, Margulis V, Cadeddu JA, Ross MT, Bentley DR, Kabbani W, Xie XJ, Kapur P, Williams NS, Brugarolas J. Sci. Transl. Med. 2012 4 137 137ra75
An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis
Huang X, Dong Y, Bey EA, Kilgore JA, Bair JS, Li LS, Patel M, Parkinson EI, Wang Y, Williams NS, Gao J, Hergenrother PJ, Boothman DA. Cancer Res. 2012 72 12 3038-47
Development of proneurogenic, neuroprotective small molecules.
MacMillan KS, Naidoo J, Liang J, Melito L, Williams NS, Morlock L, Huntington PJ, Estill SJ, Longgood J, Becker GL, McKnight SL, Pieper AA, De Brabander JK, Ready JM J. Am. Chem. Soc. 2011 Feb 133 5 1428-37
Discovery of a proneurogenic, neuroprotective chemical.
Pieper AA, Xie S, Capota E, Estill SJ, Zhong J, Long JM, Becker GL, Huntington P, Goldman SE, Shen CH, Capota M, Britt JK, Kotti T, Ure K, Brat DJ, Williams NS, MacMillan KS, Naidoo J, Melito L, Hsieh J, De Brabander J, Ready JM, McKnight SL Cell 2010 Jul 142 1 39-51
Structure-activity relationship studies of small-molecule inhibitors of Wnt response.
Lu J, Ma Z, Hsieh JC, Fan CW, Chen B, Longgood JC, Williams NS, Amatruda JF, Lum L, Chen C Bioorg. Med. Chem. Lett. 2009 Jul 19 14 3825-7
Targeting QseC signaling and virulence for antibiotic development
Rasko, DA, CG Moreira, DR Li, NC Reading, JM Ritchie, MK Waldor, N Williams, R Taussig, S Wei, M Roth, DT Hughes, JF Huntley, MW Fina, JR Falck, and V Sperandio Science August 2008 321 1078-1080
Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease
De Jesús-Cortés H, Xu P, Drawbridge J, Estill SJ, Huntington P, Tran S, Britt J, Tesla R, Morlock L, Naidoo J, Melito LM, Wang G, Williams NS, Ready JM, McKnight SL, Pieper AA. Proc. Natl. Acad. Sci. 2012 109 42 17010-5
Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis
Tesla R, Wolf HP, Xu P, Drawbridge J, Estill SJ, Huntington P, McDaniel L, Knobbe W, Burket A, Tran S, Starwalt R, Morlock L, Naidoo J, Williams NS, Ready JM, McKnight SL, Pieper AA. Proc. Natl. Acad. Sci. 2012 109 42 17016-21
Regulation of VEGF-induced endothelial cell migration by mitochondrial reactive oxygen species.
Wang Y, Zang QS, Liu Z, Wu Q, Maass D, Dulan G, Shaul PW, Melito L, Frantz DE, Kilgore JA, Williams NS, Terada LS, Nwariaku FE Am. J. Physiol., Cell Physiol. 2011 Sep 301 3 C695-704
Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor.
Mata MA, Satterly N, Versteeg GA, Frantz D, Wei S, Williams N, Schmolke M, Peña-Llopis S, Brugarolas J, Forst CV, White MA, García-Sastre A, Roth MG, Fontoura BM Nat. Chem. Biol. 2011 7 10
