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Matthew Parker, Ph.D.

Matthew Parker, Ph.D.

Assistant Professor

Endowed Title
Cecil H. and Ida Green Endowed Scholar in Biomedical Computational Science
School
Medical School
Department
Biophysics
Graduate Programs
Molecular Biophysics
  • Biography
  • Research Interest
    • Bioinformatics
    • Chromatin-binding proteins
    • Condensates
    • DNA replication initiation
    • Protein biochemistry
    • Protein intrinsically disordered regions
    • Protein phase separation
  • Publications

    Star Featured Publications

    Featured Featured
    Molecular determinants of phase separation for Drosophila DNA replication licensing factors
    Parker, MW, Kao, JA, Huang A, Berger, JM, Botchan, MR bioRxiv 2021
    Design, synthesis, and evaluation of a novel benzamidine-based inhibitor of VEGF-C binding to Neuropilin-2.
    Said AM, Parker MW, Vander Kooi CW, Bioorganic chemistry 2020 Jul 100 103856
    A new class of disordered elements controls DNA replication through initiator self-assembly.
    Parker MW, Bell M, Mir M, Kao JA, Darzacq X, Botchan MR, Berger JM, eLife 2019 09 8
    Mechanisms and regulation of DNA replication initiation in eukaryotes.
    Parker MW, Botchan MR, Berger JM, Critical reviews in biochemistry and molecular biology 2017 Apr 52 2 107-144
    Plate-Based Assay for Measuring Direct Semaphorin-Neuropilin Interactions.
    Parker MW, Vander Kooi CW, Methods in molecular biology (Clifton, N.J.) 2017 1493 73-87
    Expanding the 3-O-Sulfate Proteome--Enhanced Binding of Neuropilin-1 to 3-O-Sulfated Heparan Sulfate Modulates Its Activity.
    Thacker BE, Seamen E, Lawrence R, Parker MW, Xu Y, Liu J, Vander Kooi CW, Esko JD, ACS chemical biology 2016 Apr 11 4 971-80
    Structural basis for VEGF-C binding to neuropilin-2 and sequestration by a soluble splice form.
    Parker MW, Linkugel AD, Goel HL, Wu T, Mercurio AM, Vander Kooi CW, Structure (London, England : 1993) 2015 Apr 23 4 677-87
    Structural mechanism of laforin function in glycogen dephosphorylation and lafora disease.
    Raththagala M, Brewer MK, Parker MW, Sherwood AR, Wong BK, Hsu S, Bridges TM, Paasch BC, Hellman LM, Husodo S, Meekins DA, Taylor AO, Turner BD, Auger KD, Dukhande VV, Chakravarthy S, Sanz P, Woods VL, Li S, Vander Kooi CW, Gentry MS, Molecular cell 2015 Jan 57 2 261-72
  • Honors & Awards
    • Cancer Prevention & Research Institute of Texas (CPRIT) Scholar
      (2020)
    • Cecil H. and Ida Green Endowed Scholar in Biomedical Computational Science
      (2020)