Ravikanth “Ravi Maddipati” Maddipati, M.D.

Download Curriculum Vitae

Ravikanth Maddipati, M.D., is an Assistant Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of its Division of Digestive and Liver Diseases. His clinical interests are in pancreatic disorders, including pancreatitis and pancreatic cancer, cancer genetics, screening of high risk and hereditary gastrointestinal malignances, and general gastroenterology.

Dr. Maddipati holds a bachelor's degree in computer and electrical engineering from the University of Michigan, where he graduated magna cum laude. He remained there to obtain a master's degree in biomedical engineering. He earned his medical degree with honors from Boston University School of Medicine and completed internal medicine residency training at Massachusetts General Hospital. He then received advanced training in gastroenterology through a fellowship at the University of Pennsylvania.

Certified by the American Board of Internal Medicine, Dr. Maddipati joined the UT Southwestern faculty in 2019. 

His research interests include pancreatic cancer, tumor metastasis, and pancreatitis.

Dr. Maddipati is a member of the American Association for Cancer Research, the American Association for the Study of Liver Diseases, the American Gastroenterological Association, the American Pancreatic Association, and the American Society for Gastrointestinal Endoscopy.

Medical School

Boston University School of Medicine (2008)

Residency

Massachusetts General Hospital (2010), Internal Medicine

Fellowship

Hospital of the University of Pennsylvania (2014), Gastroenterology

• Cancer Metastasis
• Pancreatic Cancer
• Tumor Heterogeneity
• Tumor Immunology
• Tumor Metabolism

Featured Publications

Ablative radiotherapy in oligometastatic pancreatic cancer to delay polyprogression, limit chemotherapy, and improve outcomes.

Elamir AM, Karalis JD, Sanford NN, Polanco PM, Folkert MR, Porembka MR, Kazmi SA, Maddipati R, Zeh HJ, Timmerman RD, Zhang S, Ligorio M, Beg MS, Aguilera TA, Int J Radiat Oncol Biol Phys 2022 Jul

Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer.

Huang H, Wang Z, Zhang Y, Pradhan RN, Ganguly D, Chandra R, Murimwa G, Wright S, Gu X, Maddipati R, Müller S, Turley SJ, Brekken RA, Cancer Cell 2022 Apr

MYC levels regulate metastatic heterogeneity in pancreatic adenocarcinoma.

Maddipati R, Norgard RJ, Baslan T, Rathi KS, Zhang A, Saeid A, Higashihara T, Wu F, Kumar A, Annamalai V, Bhattacharya S, Raman P, Adkisson CA, Pitarresi JR, Wengyn MD, Yamazoe T, Li J, Balli D, LaRiviere MJ, Ngo TC, Folkert IW, Millstein ID, Bermeo J, Carpenter EL, McAuliffe JC, Oktay MH, Brekken RA, Lowe SW, Iacobuzio-Donahue CA, Notta F, Stanger BZ, Cancer Discov 2021 Sep

Calcium signaling induces a partial EMT.

Norgard RJ, Pitarresi JR, Maddipati R, Aiello-Couzo NM, Balli D, Li J, Yamazoe T, Wengyn MD, Millstein ID, Folkert IW, Rosario-Berrios DN, Kim IK, Bassett JB, Payne R, Berry CT, Feng X, Sun K, Cioffi M, Chakraborty P, Jolly MK, Gutkind JS, Lyden D, Freedman BD, Foskett JK, Rustgi AK, Stanger BZ, EMBO Rep 2021 Jul e51872

Cancer-Associated Fibroblasts: Versatile Players in the Tumor Microenvironment.

Ganguly D, Chandra R, Karalis J, Teke M, Aguilera T, Maddipati R, Wachsmann MB, Ghersi D, Siravegna G, Zeh HJ, Brekken R, Ting DT, Ligorio M, Cancers (Basel) 2020 Sep 12 9

Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer.

Reichert M, Bakir B, Moreira L, Pitarresi JR, Feldmann K, Simon L, Suzuki K, Maddipati R, Rhim AD, Schlitter AM, Kriegsmann M, Weichert W, Wirth M, Schuck K, Schneider G, Saur D, Reynolds AB, Klein-Szanto AJ, Pehlivanoglu B, Memis B, Adsay NV, Rustgi AK, Dev. Cell 2018 06 45 6 696-711.e8

EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration.

Aiello NM, Maddipati R, Norgard RJ, Balli D, Li J, Yuan S, Yamazoe T, Black T, Sahmoud A, Furth EE, Bar-Sagi D, Stanger BZ, Dev. Cell 2018 06 45 6 681-695.e4

Pancreatic cancer survival analysis defines a signature that predicts outcome.

Raman P, Maddipati R, Lim KH, Tozeren A, PLoS ONE 2018 13 8 e0201751

KLF4 Initiates Acinar Cell Reprogramming and Is Essential for the Early Stages of Pancreatic Carcinogenesis.

Maddipati R, Katz JP, Cancer Cell 2016 Mar 29 3 247-248

Pancreatic Cancer Metastases Harbor Evidence of Polyclonality.

Maddipati R, Stanger BZ, Cancer Discov 2015 Oct 5 10 1086-97

 Featured Books

Liver and Pancreas: Mechanisms of Development and Size Control. In Stem Cells: From Basic Research to Therapy

Maddipati, R., Stanger, B.Z (2014). Science Publishers

• NIH Directors New Innovator Award-DP2
  Award to develop novel optogenetic based tools for in vivo tumor modeling and studies of tumor heterogeneity and metastasis. (2023)
• CPRIT Scholar in Cancer Research
  Cancer Prevention Research Institute of Texas (2019)
• Disease Oriented Clinical Scholar
  Disease-Oriented Clinical Scholars (DOCS) program, UTSW (2019)
• Caroline Craig Augustyn & Damian Augustyn Award in Digestive Cancer
  American Gastroenterological Association (2018)
• Frank Brooks Excellence in Research Award
  University of Pennsylvania (2013)
• HHMI Medical Research Scholar
  Howard Hughes Medical Institute (2006)

• American Association of Cancer Research
• American Gastroenterological Association
• American Pancreas Association
• American Society for Gastrointestinal Endoscopy