Venuprasad Poojary, Ph.D.

Venuprasad Poojary, Ph.D., is an Associate Professor in the Departments of Internal Medicine and Immunology at UT Southwestern Medical Center and a member of the Division of Digestive and Liver Diseases.

Originally from Mangalore, India, Dr. Poojary holds a bachelor's degree in biochemistry and a master's degree in bioscience from Mangalore University. He earned his doctoral degree in immunology at the National Center for Cell Science in Kolkata, India. He was a postdoctoral fellow in immunology and cell signaling at the La Jolla Institute for Allergy and Immunology in San Diego, California.

Dr. Poojary joined the UT Southwestern faculty in 2019.

Dr. Poojary is a member of the American Association of Immunologists, the American Association for Cancer Research, the American Society of Cell Biology, and the American Association for the Advancement of Science.

• Colon Cancer
• Gut Microbiota
• Inflammasome
• Inflammatory Bowel Diseases (IBDs)
• Th17/Treg Differentiation

Featured Publications

RORγt-Raftlin1 complex regulates the pathogenicity of Th17 cells and colonic inflammation.

Singh AK, Kumar R, Yin J, Brooks Ii JF, Kathania M, Mukherjee S, Kumar J, Conlon KP, Basrur V, Chen Z, Han X, Hooper LV, Burstein E, Venuprasad K, Nat Commun 2023 Aug 14 1 4972

Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy.

Alula KM, Delgado-Deida Y, Callahan R, Till A, Underwood L, Thompson WE, Souza RF, Dassopoulos T, Onyiah J, Venuprasad K, Theiss AL, Sci Rep 2023 Jan 13 1 18

Pak2-mediated phosphorylation promotes ROR?t ubiquitination and inhibits colonic inflammation.

Kathania M, Kumar R, Lenou ET, Basrur V, Theiss AL, Chernoff J, Venuprasad K, Cell Rep 2022 Sep 40 11 111345

ROR?t protein modifications and IL-17-mediated inflammation.

Kumar R, Theiss AL, Venuprasad K, Trends Immunol 2021 Nov 42 11 1037-1050

Targeting Mitochondrial Damage as a Therapeutic for Ileal Crohn's Disease.

Alula KM, Jackson DN, Smith AD, Kim DS, Turner K, Odstrcil E, Kaipparettu BA, Dassopoulos T, Venuprasad K, Feagins LA, Theiss AL, Cells 2021 May 10 6

NLRP6 in host defense and intestinal inflammation.

Venuprasad K, Theiss AL, Cell Rep 2021 Apr 35 4 109043

Cutting Edge: Hypoxia-Induced Ubc9 Promoter Hypermethylation Regulates IL-17 Expression in Ulcerative Colitis.

Kumar R, Singh AK, Starokadomskyy P, Luo W, Theiss AL, Burstein E, Venuprasad K, J Immunol 2021 Mar 206 5 936-940

Nuclear partitioning of Prohibitin 1 inhibits Wnt/β-catenin-dependent intestinal tumorigenesis.

Alula KM, Delgado-Deida Y, Jackson DN, Venuprasad K, Theiss AL, Oncogene 2021 Jan 40 2 369-383

Deletion of Cbl-b inhibits CD8⁺ T-cell exhaustion and promotes CAR T-cell function.

Kumar J, Kumar R, Kumar Singh A, Tsakem EL, Kathania M, Riese MJ, Theiss AL, Davila ML, Venuprasad K, J Immunother Cancer 2021 Jan 9 1

The synthetic small molecule FL3 combats intestinal tumorigenesis via Axin1-mediated inhibition of Wnt/beta-catenin signaling.

Jackson DN, Alula KM, Delgado-Deida Y, Tabti R, Turner K, Wang X, Venuprasad K, Souza RF, Désaubry L, Theiss AL, Cancer Res. 2020 Jul

 Featured Books

Immune regulation by ubiquitin conjugation. In Lymphocyte Signal Transduction

Venuprasad K, Yang C, Shao Y, Demydenko D, Harada Y, Jeon MS, Liu YC. (2008). Springer Link

Cbl-b-mediated regulation of cell signaling and cancer. In Signaling Pathways in Immune Cells

Venuprasad K. (2011). Springer Link

• American Association for Advancement of Science (2009)
• American Association for Cancer Research (2009)
• American Association of Immunologists (2006)
• American Society of Cell Biology (2009)