Andrew Zinn, M.D., Ph.D.

Dean, UT Southwestern Graduate School of Biomedical Sciences

Professor

Endowed Title: Rolf Haberecht and Ute Schwarz Haberecht Deanship of the UT Southwestern Graduate School of Biomedical Sciences

Department: Office of the Dean - Southwestern Graduate School, Eugene McDermott Center for Human Growth & Development, Internal Medicine

Graduate Programs: Genetics and Development, Integrative Biology

Biography

Dr. Zinn received his B.A. degree in 1981 from Plan II at The University of Texas at Austin, where he did research on ribosome structure with biochemist Boyd Hardesty, Ph.D. He received his MD and PhD degrees from the UT Southwestern Medical Scientist Training Program (MSTP) in 1988. His dissertation research under the mentorship of Ronald Butow, Ph.D. concerned yeast mitochondrial genetics. Dr. Zinn then did a residency in internal medicine at Massachusetts General Hospital, followed by a postdoctoral fellowship in human genetics in the lab of David Page, MD, at the Whitehead Institute, MIT. He returned to UT Southwestern in 1993 as an independent research fellow and was appointed to the faculty in 1996. In 2008 he became the director of the MSTP, and in 2013 he was appointed Dean of the Graduate School of Biomedical Sciences. He maintains an active lab in the Eugene McDermott Center for Human Growth and Development. His research program focuses on human genetic growth disorders, including sex chromosome abnormalities, hereditary obesity, and other rare genetic diseases.

Education

Undergraduate University of Texas at Austin (1981), Liberal Arts
Medical School University of Texas Southwestern Med Ctr Dallas (1988)
Graduate School University of Texas Southwestern Med Ctr Dallas (1988)

Research Interests

  • Chromosome abnormalities
  • Copy number variation
  • Obesity

Publications

Featured Publications Legend

Featured Publications

Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and Oxytocin expression

Tolson KP, Gemelli T, Gautron L, Elmquist JK, Zinn AR* and Kublaoui BM* (*Equal contributors). J Neurosci 2010 30 3803

Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice

Kublaoui BM, Gemelli T, Tolson KP, Wang Y, Zinn AR Mol Endocrinol 2008 22 1723-1734

SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake.

Kublaoui BM, Holder JL Jr, Tolson KP, Gemelli T, Zinn AR Endocrinology 2006 147 4542-4549

Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons.

Kublaoui BM, Holder JL Jr, Gemelli T, Zinn AR. Mol Endocrinol 2006 20 2483-2492

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Honors/Awards

  • Pfizer Scholar
    (1994)
  • Damon Runyon-Walter Winchell Cancer Research Fund Fellowship
    (1990-1993) (1990)
  • NIDDK Medical Resident Award
    (1990)
  • Nominata Award for Outstanding Research, UT Southwestern
    (1988)

Professional Associations/Affiliations

  • American Society for Human Genetics