Featured Publications
Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and Oxytocin expression
Tolson KP, Gemelli T, Gautron L, Elmquist JK, Zinn AR* and Kublaoui BM* (*Equal contributors) J Neurosci 2010 30 3083
Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice
Kublaoui BM, Gemelli T, Tolson KP, Wang Y, Zinn AR Mol Endocrinol 2008 22 1723-1734
Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons
Kublaoui BM, Holder JL Jr, Gemelli T, Zinn AR Mol Endocrinol 2006 20 2483-2492
Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice
Holder Jr JL, Zhang L, Kublaoui BM, DiLeone RJ, Oz OK, Bair CH, Lee YH, and Zinn AR Am J Phys Endocrinol Metab 2004 287 E105-13
Profound obesity associated with a balanced translocation that disrupts the SIM1 gene
Holder Jr. JL, Butte NF, Zinn AR Hun Mol Gen 2000 9 101-108
Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and Oxytocin expression
Tolson KP, Gemelli T, Gautron L, Elmquist JK, Zinn AR* and Kublaoui BM* (*Equal contributors). J Neurosci 2010 30 3803
Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice
Kublaoui BM, Gemelli T, Tolson KP, Wang Y, Zinn AR Mol Endocrinol 2008 22 1723-1734
SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake.
Kublaoui BM, Holder JL Jr, Tolson KP, Gemelli T, Zinn AR Endocrinology 2006 147 4542-4549
Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons.
Kublaoui BM, Holder JL Jr, Gemelli T, Zinn AR. Mol Endocrinol 2006 20 2483-2492
