Dr. Yin’s research at UT Southwestern involves the study of the actin cytoskeleton which serves many essential functions. Actin polymerization drives membrane movements, and actin filaments assemble into a scaffold that supports the cells’ motors and signaling machinery. The scaffold is continually remodeled in proliferating cells, and is completely dismantled in apoptotic cells.

Dr. Yin is studying how the membrane lipids phosphatidylinositol 4,5 bisphosphate (PIP2) and phosphatidylinositol 4 phosphate (PI4P)  regulates the actin scaffold and membrane trafficking in proliferating and autophagic  cells. She focuses on the lipid kinases that synthesize PIP2 and the regulatory proteins that respond to PIP2. Her lab is currently pursuing the following projects:

  • PIP2 regulates the actin cytoskeleton,vesicle transport, intracellular calcium signaling and apoptosis
  • PI4P regulation of the actin cytoskeleton, Golgi trafficking and autophagy



Mount Holyoke College (1970), Biology
Graduate School
Harvard University (1976), Physiology

Research Interest

  • Differential targeting of type II phosphatidylinositol 4 kinase alpha and beta to the Golgi and the plasma membrane
  • Phosphoinositide regulation of the actin cytoskeleton, membrane trafficking and autophagy
  • Phosphoinositide regulation of the Golgi


Featured Publications LegendFeatured Publications

Phosphatidylinositol 4-Kinase IIa Is Palmitoylated by Golgi-localized Palmitoyltransferases in Cholesterol-dependent Manner.
Lu D, Sun HQ, Wang H, Barylko B, Fukata Y, Fukata M, Albanesi JP, Yin HL J. Biol. Chem. 2012 Jun 287 26 21856-65
Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeleton.
Zhang L, Mao YS, Janmey PA, Yin HL Subcell. Biochem. 2012 59 177-215
Oxidative stress decreases phosphatidylinositol 4,5-bisphosphate levels by deactivating phosphatidylinositol- 4-phosphate 5-kinase beta in a Syk-dependent manner.
Chen MZ, Zhu X, Sun HQ, Mao YS, Wei Y, Yamamoto M, Yin HL J. Biol. Chem. 2009 Aug 284 35 23743-53
Palmitoylation Controls the Catalytic Activity and Subcellular Distribution of Phosphatidylinositol 4-Kinase IIalpha
Barylko B, Mao YS, Wlodarski P, Jung G, Binns DD, Sun HQ, Yin HL, Albanesi JP J Biol Chem February 2009 [Epub ahead of print]

Honors & Awards

  • Inaugural holder of the Margaret Yin Chair for the Advancement of Women Faculty
  • The Innovation in Health Science Education Award, University of Texas System Kenneth Shine Academy
  • Distinguished Teaching Professor, University of Texas System Kenneth Shine Academy of Health Science Education
  • 2000 - 2004
    Editorial Board, Journal of Biological Chemistry (0)
  • 2006
    Peter and Jean D. Dehlinger Professorship in Biomedical Sciences (0)
  • 2006 - 2007
    Fellow of the Executive Leadership in Academic Medicine Program (ELAM), Drexel College of Medicine

Professional Associations/Affiliations

  • Director, NIH T32 Institutional Training Grant (2015-2020)
  • 2008-Present: Director, HHMI Med Grad Mech of Disease & Transl. Sci. Track, Southwestern Graduate School (2008-2015)