Helen Yin, Ph.D.

Professor

Endowed Title: Peter and Jean D. Dehlinger Professorship in Biomedical Science

Department: Physiology, Faculty Diversity & Development

Graduate Programs: Cell Regulation, Integrative Biology

Biography

Dr. Yin’s research at UT Southwestern involves the study of the actin cytoskeleton which serves many essential functions. Actin polymerization drives membrane movements, and actin filaments assemble into a scaffold that supports the cells’ motors and signaling machinery. The scaffold is continually remodeled in proliferating cells, and is completely dismantled in apoptotic cells.

Dr. Yin is studying how phosphatidylinositol 4,5 bisphosphate (PIP2), a membrane lipid, regulates the actin scaffold in proliferating and apoptotic cells. She focuses on the lipid kinases that synthesize PIP2 and the regulatory proteins that respond to PIP2. Her lab is currently pursuing the following projects:

  • PIP2 regulates the actin cytoskeleton,vesicle transport, intracellular calcium signaling and apoptosis
  • PI4P regulation of Golgi trafficking
  • Effect of burn injury on PIP2 and PI4P homeostasis

Education

Undergraduate Mount Holyoke College (1970)
Graduate School Harvard University (1976)

Research Interests

  • Differential targeting of type II phosphatidylinositol 4 kinase alpha and beta to the Golgi and the plasma membrane
  • Phosphoinositide regulation of the actin cytoskeleton and apoptosis
  • Phosphoinositide regulation of the Golgi
  • Role of the extracellular actin scavenging system and hypertonic resuscitation in protection against burn and oxidant injuries.

Publications

Featured Publications Legend

Featured Publications

Phosphatidylinositol 4-Kinase IIa Is Palmitoylated by Golgi-localized Palmitoyltransferases in Cholesterol-dependent Manner.

Lu D, Sun HQ, Wang H, Barylko B, Fukata Y, Fukata M, Albanesi JP, Yin HL J. Biol. Chem. 2012 Jun 287 26 21856-65

Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeleton.

Zhang L, Mao YS, Janmey PA, Yin HL Subcell. Biochem. 2012 59 177-215

Oxidative stress decreases phosphatidylinositol 4,5-bisphosphate levels by deactivating phosphatidylinositol- 4-phosphate 5-kinase beta in a Syk-dependent manner.

Chen MZ, Zhu X, Sun HQ, Mao YS, Wei Y, Yamamoto M, Yin HL J. Biol. Chem. 2009 Aug 284 35 23743-53

Palmitoylation Controls the Catalytic Activity and Subcellular Distribution of Phosphatidylinositol 4-Kinase IIalpha

Barylko B, Mao YS, Wlodarski P, Jung G, Binns DD, Sun HQ, Yin HL, Albanesi JP J Biol Chem February 2009 [Epub ahead of print]

Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis

Mao YS, Yamaga M, Zhu X, Wei Y, Sun HQ, Wang J, Yun M, Wang Y, Di Paolo G, Bennett M, Mellman I, Abrams CS, De Camilli P, Lu CY, Yin HL J Cell Biol January 2009 184(2) 281-96

Results 1-10 of 12

Honors/Awards

  • 2000 - 2004
    Editorial Board, Journal of Biological Chemistry (0)
  • 2006
    Peter and Jean D. Dehlinger Professorship in Biomedical Sciences (0)
  • 2006 - 2007
    Fellow of the Executive Leadership in Academic Medicine Program, Drexel College of Medicine (0)

Professional Associations/Affiliations

  • 2008-Present: Director, HHMI Med Grad Mech of Disease & Transl. Sci. Track, Southwestern Graduate School (2008)