My research is focused on regulation of the actin cytoskeleton and membrane trafficking by the phospholipids phosphatidylinositol 4,5 bisphosphate (PIP2) and phosphatidylinositol 4 phosphate (PI4P). I elucidated the roles of the lipid kinases that generate PIP2 and PI4P in response to hypertonic and oxidative stress, during membrane signaling, phagocytosis and autophagy. My contributions improve understanding of these essential lipids’ role in cell survival and organelle remodeling, membrane trafficking, innate host response and inflammation.
I am a strong advocate for translational science, as evidenced by my creation of the UT Southwestern “Mechanisms of Disease & Translational Science” graduate track in 2008 and my role as co-director of the “Education and Career Development Core” of the UT Southwestern Clinical and Translational Science Award (CTSA) since 2011. The Mechanism of Disease and Translational Science graduate track will train PhD students with a foundation in the molecular basis of disease, and will increase their ability to target their research to address unmet diagnostic and therapeutic needs. This PhD track has been supported by the Howard Hughes Medical Institute “Med into Grad” Initiative and by an NIH Molecular Medicine T32 Institutional Training Grant. I was elected as Distinguished Professor by the University of Texas System in 2014, and won the University of Texas Academy of Health Science Education’s Innovator Award in 2015.
In addition to my scientific and education roles, I am also the Associate Dean for the Office of Women’s Careers. In this role, I advocate for our faculty, with particular focus on women and diverse faculty. I am active in the University of Texas System’s “Quantum Leap Initiative” as a member of the Committee for Gender Pay Equity and Committee on Women Leadership Development. I am on the national program planning community for the upcoming Summit on “Inspiring Intersections: A Call to Collaborate, Challenge, and Change” that is co-sponsored by the AAMC Group on Faculty Diversity and Inclusion and Group on Women in Medicine and Science.
- Mount Holyoke College (1970), Biology
- Graduate School
- Harvard University (1976), Physiology
- Differential targeting of type II phosphatidylinositol 4 kinase alpha and beta to the Golgi and the plasma membrane
- Phosphoinositide regulation of the actin cytoskeleton, membrane trafficking and autophagy
- Phosphoinositide regulation of the Golgi
- GABARAPs regulate PI4P-dependent autophagosome:lysosome fusion
- Wang, H, Sun HQ, Zhu X, Zhang Li, Albanesi J, Levine B, Yin H Proc Natil Acad Science 2015 112:7015-20
- Sustaining the clinical and translational research workforce: Training and empowering the next generation of investigators
- Yin HL, Gabrilove J, Jackson R, Sweeney C, Fair AL, Toto R. Acad Med 2015 90:861-5.
- Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi
- Wang YJ, Wang J, Sun HQ, Martinez M, Sun YX, Macia E, Kirchhausen T, Albanesi JP, Roth MG, Yin HL Cell August 2003 114(3) 299-310
- Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3
- Rozelle AL, Machesky LM, Yamamoto M, Driessens MH, Insall RH, Roth MG, Luby-Phelps K, Marriott G, Hall A, Yin HL Curr Biol March 2000 10(6) 311-20
- gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein
- Yu FX, Johnston PA, Sudhof TC, Yin HL Science December 1990 250(4986) 1413-5
- Control of cytoplasmic actin gel-sol transformation by gelsolin, a calcium-dependent regulatory protein
- Yin HL, Stossel TP Nature October 1979 281(5732) 583-6
- Phosphatidylinositol 4-Kinase IIa Is Palmitoylated by Golgi-localized Palmitoyltransferases in Cholesterol-dependent Manner.
- Lu D, Sun HQ, Wang H, Barylko B, Fukata Y, Fukata M, Albanesi JP, Yin HL J. Biol. Chem. 2012 Jun 287 26 21856-65
- Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeleton.
- Zhang L, Mao YS, Janmey PA, Yin HL Subcell. Biochem. 2012 59 177-215
- Oxidative stress decreases phosphatidylinositol 4,5-bisphosphate levels by deactivating phosphatidylinositol- 4-phosphate 5-kinase beta in a Syk-dependent manner.
- Chen MZ, Zhu X, Sun HQ, Mao YS, Wei Y, Yamamoto M, Yin HL J. Biol. Chem. 2009 Aug 284 35 23743-53
- Palmitoylation Controls the Catalytic Activity and Subcellular Distribution of Phosphatidylinositol 4-Kinase IIalpha
- Barylko B, Mao YS, Wlodarski P, Jung G, Binns DD, Sun HQ, Yin HL, Albanesi JP J Biol Chem February 2009 [Epub ahead of print]
Honors & Awards
- Inaugural holder of the Margaret Yin Chair for the Advancement of Women Faculty
- The Innovation in Health Science Education Award, University of Texas System Kenneth Shine Academy
- Distinguished Teaching Professor, University of Texas System Kenneth Shine Academy of Health Science Education
- 2000 - 2004
Editorial Board, Journal of Biological Chemistry (0)
Peter and Jean D. Dehlinger Professorship in Biomedical Sciences (0)
- 2006 - 2007
Fellow of the Executive Leadership in Academic Medicine Program (ELAM), Drexel College of Medicine
- Director, NIH T32 Institutional Training Grant (2015-2020)
- Director, HHMI Med Grad Mech of Disease & Transl. Sci. Track, Southwestern Graduate School (2008-2015)