Jin Ye received a M. degree in Biochemistry from Case Western Reserve University in 1995. He was mentored by Nobel laureates Michael Brown and Joseph Goldstein at UT Southwestern, obtaining his PhD in Cell Regulation in 2000, and continuing in a postdoctoral fellowship from 2000 to 2004.He joined the faculty at the UT Southwestern Medical Center in 2004 as an Assistant Professor.

Dr. Ye’s research interests are to understand the physiological and pathological actions of isoprenoids derived from the mevalonate pathway. His current research points out the importance of the geranylgeranyl lipid for hepatitis C virus (HCV) RNA replication, providing a potential new target for treatment of HCV. Dr. Ye is affiliated with the graduate school at UT Southwestern. He is currently appointed as a full member of the graduate faculty in the Biological Chemistry Program.


Graduate School
Case Western Reserve Universit (1995), Biochemistry
Graduate School
Unlisted - College or Universi (2000), None
Graduate School
Central South Univ, Xiang-Ya S (2000), None

Research Interest

  • Host factors required for HCV replication
  • Regulation of lipid metabolism


Featured Publications LegendFeatured Publications

Inverting the Topology of a Transmembrane Protein by Regulating the Translocation of the First Transmembrane Helix.
Chen Q, Denard B, Lee CE, Han S, Ye JS, Ye J Mol. Cell 2016 Aug 63 4 567-78
Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of ß-Catenin.
Kim H, Rodriguez-Navas C, Kollipara RK, Kapur P, Pedrosa I, Brugarolas J, Kittler R, Ye J Cell Rep 2015 Oct 13 3 495-503
Identification of CREB3L1 as a Biomarker Predicting Doxorubicin Treatment Outcome.
Denard B, Pavia-Jimenez A, Chen W, Williams NS, Naina H, Collins R, Brugarolas J, Ye J PLoS ONE 2015 10 6 e0129233
Sustained Induction of Collagen Synthesis by TGF-ß Requires Regulated Intramembrane Proteolysis of CREB3L1.
Chen Q, Lee CE, Denard B, Ye J PLoS ONE 2014 9 10 e108528
Nrf1 to the rescue.
Ye J Elife 2014 3 e02062
Cellular responses to excess fatty acids: focus on ubiquitin regulatory X domain-containing protein 8.
Kim H, Ye J Curr. Opin. Lipidol. 2013 Dec
Roles of regulated intramembrane proteolysis in virus infection and antiviral immunity.
Ye J Biochim. Biophys. Acta 2013 Dec 1828 12 2926-32