Jin Ye received a M. degree in Biochemistry from Case Western Reserve University in 1995. He was mentored by Nobel laureates Michael Brown and Joseph Goldstein at UT Southwestern, obtaining his PhD in Cell Regulation in 2000, and continuing in a postdoctoral fellowship from 2000 to 2004.He joined the faculty at the UT Southwestern Medical Center in 2004 as an Assistant Professor.
Dr. Ye’s research interests are to understand the physiological and pathological actions of isoprenoids derived from the mevalonate pathway. His current research points out the importance of the geranylgeranyl lipid for hepatitis C virus (HCV) RNA replication, providing a potential new target for treatment of HCV. Dr. Ye is affiliated with the graduate school at UT Southwestern. He is currently appointed as a full member of the graduate faculty in the Biological Chemistry Program.
- Graduate School
- Case Western Reserve University (1995), Biochemistry
- Graduate School
- UT Southwestern Medical Center (cell Regulation) (2000), None
- Host factors required for HCV replication
- Regulation of lipid metabolism
- Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feed back control of cholesterol synthesis and uptake.
- Gong, Y., Lee, J., Lee, P., Goldstein, J.L., Brown, M.S. and Ye, J. Cell Metabolism 2006 3 15-24
- Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines.
- Lee, J., Gong, Y., Zhang, X., and Ye, J. Proc. Natl. Acad. Sci. USA. 2006 103 4958-4963
- Identification of FBL2 as a geranylgeranylated cellular protein required.
- Wang C., Hua, H., Gale, M., Brown, M.S., Goldstein, J.L., and Ye, J. Mol. Cell 2005 18 425-434
- Regulated erad of a polytopic protein: p97 recruits proteasomes to insig-1 before extraction from membranes.
- Ikeda, Y., Demartino, G.N., Brown, M.S., Lee, J.N., Goldstein, J.L., Ye, J. J. Biol. Chem. October 2009 Epub ahead of Print
- Apolipoprotein E on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptor.
- Owen, D.M., Huang, H., Ye, J., Gale, M. Jr. Virology September 2009 Epub ahead of Print
- Unsaturated fatty acids inhibit proteasomal degradation of insig-1 at a post-ubiquitination step.
- Lee, J.N., Zhang, X., Feramisco, J.D., Gong, Y., Ye, J. J. Biol. Chem. October 2008 [Epub ahead of print] 3
- Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells
- Yao, H. and Ye, J. J. Biol. Chem. 2008 283 849-854
- Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus.
- Ye, Jin PLoS Pathog. 2007 3 1017-1022