Jin Ye received a M. degree in Biochemistry from Case Western Reserve University in 1995. He was mentored by Nobel laureates Michael Brown and Joseph Goldstein at UT Southwestern, obtaining his PhD in Cell Regulation in 2000, and continuing in a postdoctoral fellowship from 2000 to 2004.He joined the faculty at the UT Southwestern Medical Center in 2004 as an Assistant Professor.

Dr. Ye’s research interests are to understand the physiological and pathological actions of isoprenoids derived from the mevalonate pathway. His current research points out the importance of the geranylgeranyl lipid for hepatitis C virus (HCV) RNA replication, providing a potential new target for treatment of HCV. Dr. Ye is affiliated with the graduate school at UT Southwestern. He is currently appointed as a full member of the graduate faculty in the Biological Chemistry Program.


Graduate School
Case Western Reserve Universit (1995), Biochemistry
Graduate School
Central South Univ, Xiang-Ya S (2000), None
Graduate School
Unlisted - College or Universi (2000), None

Research Interest

  • Host factors required for HCV replication
  • Regulation of lipid metabolism


Featured Publications LegendFeatured Publications

Regulated erad of a polytopic protein: p97 recruits proteasomes to insig-1 before extraction from membranes.
Ikeda, Y., Demartino, G.N., Brown, M.S., Lee, J.N., Goldstein, J.L., Ye, J. J. Biol. Chem. October 2009 Epub ahead of Print
Apolipoprotein E on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptor.
Owen, D.M., Huang, H., Ye, J., Gale, M. Jr. Virology September 2009 Epub ahead of Print
Unsaturated fatty acids inhibit proteasomal degradation of insig-1 at a post-ubiquitination step.
Lee, J.N., Zhang, X., Feramisco, J.D., Gong, Y., Ye, J. J. Biol. Chem. October 2008 [Epub ahead of print] 3
Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells
Yao, H. and Ye, J. J. Biol. Chem. 2008 283 849-854
Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus.
Ye, Jin PLoS Pathog. 2007 3 1017-1022