Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feed back control of cholesterol synthesis and uptake.
Gong, Y., Lee, J., Lee, P., Goldstein, J.L., Brown, M.S. and Ye, J. Cell Metabolism 2006 3 15-24
Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines.
Lee, J., Gong, Y., Zhang, X., and Ye, J. Proc. Natl. Acad. Sci. USA. 2006 103 4958-4963
Identification of FBL2 as a geranylgeranylated cellular protein required.
Wang C., Hua, H., Gale, M., Brown, M.S., Goldstein, J.L., and Ye, J. Mol. Cell 2005 18 425-434
Regulated erad of a polytopic protein: p97 recruits proteasomes to insig-1 before extraction from membranes.
Ikeda, Y., Demartino, G.N., Brown, M.S., Lee, J.N., Goldstein, J.L., Ye, J. J. Biol. Chem. October 2009 Epub ahead of Print
Apolipoprotein E on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptor.
Owen, D.M., Huang, H., Ye, J., Gale, M. Jr. Virology September 2009 Epub ahead of Print
Unsaturated fatty acids inhibit proteasomal degradation of insig-1 at a post-ubiquitination step.
Lee, J.N., Zhang, X., Feramisco, J.D., Gong, Y., Ye, J. J. Biol. Chem. October 2008 [Epub ahead of print] 3
Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells
Yao, H. and Ye, J. J. Biol. Chem. 2008 283 849-854
Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus.
Ye, Jin PLoS Pathog. 2007 3 1017-1022