Medical School
University of Tsukuba , Medicine
Graduate School
University of Tsukuba (1988), Pharmacology

Research Interest

  • Molecular genetics of sleep/wake regulation
  • Orphan GPCRs and their neuropeptide ligands


Featured Publications LegendFeatured Publications

Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity.
Funato H, Tsai AL, Willie JT, Kisanuki Y, Williams SC, Sakurai T, Yanagisawa M. Cell Metab. January 2009 9 64-76
Endothelin: 20 years from discovery to therapy.
Barton M, Yanagisawa M. Can J. Physiol. Pharmacol. 2008 86 485-98
An essential role for orexins in emergence from general anesthesia.
Kelz MB, Sun Y, Chen J, Cheng Meng Q, Moore JT, Veasey SC, Dixon S, Thornton M, Funato H, Yanagisawa M. Proc. Natl. Acad. Sci. USA 2008 105 1309-14
Reduced expression of the endothelin receptor type B gene in piebald mice caused by insertion of a retroposon-like element in intron 1.
Yamada T, Ohtani S, Sakurai T, Tsuji T, Kunieda T, Yanagisawa M. J. Biol. Chem. 2006 281 10799-807
The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker.
Mieda M, Williams SC, Richardson JA, Tanaka K, Yanagisawa M. Proc. Natl. Acad. Sci. USA 2006 103 12150-5

Honors & Awards

  • Bristol-Myers Squibb Achievement Award in Cardiovascular Research
  • Elected Member, National Academy of Sciences
  • The Amgen Award, American Society of Biochemistry and Molecular Biology
  • The Kilby Award, The Kilby Award Foundation
  • The Novartis Award, American Heart Association

Professional Associations/Affiliations

  • Investigator, Howard Hughes Medical Institute