Education

Medical School
University of Tsukuba , Medicine
Graduate School
University of Tsukuba (1988), Pharmacology

Research Interest

  • Molecular genetics of sleep/wake regulation
  • Orphan GPCRs and their neuropeptide ligands

Publications

Featured Publications LegendFeatured Publications

Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies.
Nagase H, Yamamoto N, Yata M, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ishikawa Y, Ogawa Y, Hirayama S, Kuroda D, Watanabe Y, Gouda H, Yanagisawa M J. Med. Chem. 2017 Jan
Peripherally administered orexin improves survival of mice with endotoxin shock.
Ogawa Y, Irukayama-Tomobe Y, Murakoshi N, Kiyama M, Ishikawa Y, Hosokawa N, Tominaga H, Uchida S, Kimura S, Kanuka M, Morita M, Hamada M, Takahashi S, Hayashi Y, Yanagisawa M Elife 2016 Dec 5
Forward-genetics analysis of sleep in randomly mutagenized mice.
Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang Z, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki M, Hotta-Hirashima N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu Q, Kume K, Wakana S, Takahashi JS, Yanagisawa M Nature 2016 Nov 539 7629 378-383
Mesolimbic neuropeptide W coordinates stress responses under novel environments.
Motoike T, Long JM, Tanaka H, Sinton CM, Skach A, Williams SC, Hammer RE, Sakurai T, Yanagisawa M Proc. Natl. Acad. Sci. U.S.A. 2016 May 113 21 6023-8
Identification of mutations through dominant screening for obesity using C57BL/6 substrains.
Hossain MS, Asano F, Fujiyama T, Miyoshi C, Sato M, Ikkyu A, Kanno S, Hotta N, Kakizaki M, Honda T, Kim SJ, Komiya H, Miura I, Suzuki T, Kobayashi K, Kaneda H, Kumar V, Takahashi JS, Wakana S, Funato H, Yanagisawa M Sci Rep 2016 6 32453
Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms.
Lee IT, Chang AS, Manandhar M, Shan Y, Fan J, Izumo M, Ikeda Y, Motoike T, Dixon S, Seinfeld JE, Takahashi JS, Yanagisawa M Neuron 2015 Mar 85 5 1086-102
Modulation of circadian glucocorticoid oscillation via adrenal opioid-CXCR7 signaling alters emotional behavior.
Ikeda Y, Kumagai H, Skach A, Sato M, Yanagisawa M Cell 2013 Dec 155 6 1323-36

Honors & Awards

  • Bristol-Myers Squibb Achievement Award in Cardiovascular Research
    (2003)
  • Elected Member, National Academy of Sciences
    (2003)
  • The Amgen Award, American Society of Biochemistry and Molecular Biology
    (1999)
  • The Kilby Award, The Kilby Award Foundation
    (1998)
  • The Novartis Award, American Heart Association
    (1998)

Professional Associations/Affiliations

  • Investigator, Howard Hughes Medical Institute